Healthy dietary pattern and their corresponding gut microbiota profile are linked to a lower risk of type 2 diabetes, independent of the presence of obesity

Background: Prediabetes and old age are both high risk factors for developing Type 2 Diabetes (T2D), while obesity is one of the most important factors triggering the disease. Nutritional interventions are the most effective tool for preventing T2D, as they improve different biochemical and anthropo...

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Autores: Díaz Rizzolo, Diana A, Kostov, Belchin, López Siles, Mireia, Serra, Assumpta, Colungo, Cristina, González de Paz, Luis, Martínez Medina, Margarita, Sisó Almirall, Antoni, Gomis, Ramon
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:España
Recursos:Universitat Oberta de Catalunya (UOC)
Repositório:O2, repositorio institucional de la UOC
OAI Identifier:oai:openaccess.uoc.edu:10609/103286
Acesso em linha:https://hdl.handle.net/10609/103286
Access Level:Acceso aberto
Palavra-chave:diet
microbiota
diabetes
nutrition
prevention
obesity
dieta
diabetis
nutrició
prevenció
obesitat
nutrición
prevención
obesidad
Diabetes -- Nutrional aspects
Diabetis -- Aspectes nutricionals
Diabetes -- Aspectos nutricionales
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spelling Healthy dietary pattern and their corresponding gut microbiota profile are linked to a lower risk of type 2 diabetes, independent of the presence of obesityDíaz Rizzolo, Diana AKostov, BelchinLópez Siles, MireiaSerra, AssumptaColungo, CristinaGonzález de Paz, LuisMartínez Medina, MargaritaSisó Almirall, AntoniGomis, RamondietmicrobiotadiabetesnutritionpreventionobesitydietamicrobiotadiabetisnutricióprevencióobesitatdietamicrobiotadiabetesnutriciónprevenciónobesidadDiabetes -- Nutrional aspectsDiabetis -- Aspectes nutricionalsDiabetes -- Aspectos nutricionalesBackground: Prediabetes and old age are both high risk factors for developing Type 2 Diabetes (T2D), while obesity is one of the most important factors triggering the disease. Nutritional interventions are the most effective tool for preventing T2D, as they improve different biochemical and anthropometric outcomes and growth-promoting/inhibiting gut microbiota populations. However, to date there are no specific dietary recommendations to stop the development of T2D in elderly groups, for whom hypocaloric diets and other commonly used weight-loss programs could be considered dangerous. The objective of our study, thus, was to understand the impact of dietary patterns on T2D risk as related to gut microbiota profile in obese and non-obese elderly prediabetic subjects. Methods: A cross-sectional study was performed in 182 subjects >65 years old with prediabetes, divided into obese (OB) or non-obese (NOB) subgroups, and their risk of developing T2D was measured according to FINDRISK score and biochemical parameters. Also, clusters into different dietary patterns in each group by PCA analysis was related with gut microbiota, which was analyzed from stool samples by qPCR. The creation of clusters was used to re-evaluate T2D risk. Results: OB was at higher risk of developing T2D and showed worse metabolic outcomes. Unhealthier and healthier dietary pattern clusters were observed for both OB (OB-6 and OB-5 respectively) and NOB (NOB-2 and NOB-3 respectively) groups. Results obtained from the gut microbiota showed that only Prevotella was higher in NOB, but when comparisons were made between clusters, a clear relation with dietary pattern was observed; showing in healthier dietary clusters a decrease in Prevotella, an increase of Faecalibacterium prausnitzii and an increase in lactic acid bacteria. T2D risk was greater in the obese group between unhealthier dietary clusters. No difference between healthier dietary clusters was observed. Conclusion: A healthy dietary pattern and the growth-promoting beneficial and growth-inhibiting disadvantageous gut microbiota populations linked to it provide protection against the development of T2D in an obese population with advanced age and preDM.Clinical NutritionInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Universitat de GironaUniversitat Oberta de Catalunya (UOC)201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/10609/103286reponame:O2, repositorio institucional de la UOCinstname:Universitat Oberta de Catalunya (UOC)InglésClinical Nutrition, 2020, 39(2)https://doi.org/10.1016/j.clnu.2019.02.035CC BY-NC-NDhttp://creativecommons.org/licenses/by-nc-nd/4.0/es/info:eu-repo/semantics/openAccessoai:openaccess.uoc.edu:10609/1032862026-05-28T12:42:01Z
dc.title.none.fl_str_mv Healthy dietary pattern and their corresponding gut microbiota profile are linked to a lower risk of type 2 diabetes, independent of the presence of obesity
title Healthy dietary pattern and their corresponding gut microbiota profile are linked to a lower risk of type 2 diabetes, independent of the presence of obesity
spellingShingle Healthy dietary pattern and their corresponding gut microbiota profile are linked to a lower risk of type 2 diabetes, independent of the presence of obesity
Díaz Rizzolo, Diana A
diet
microbiota
diabetes
nutrition
prevention
obesity
dieta
microbiota
diabetis
nutrició
prevenció
obesitat
dieta
microbiota
diabetes
nutrición
prevención
obesidad
Diabetes -- Nutrional aspects
Diabetis -- Aspectes nutricionals
Diabetes -- Aspectos nutricionales
title_short Healthy dietary pattern and their corresponding gut microbiota profile are linked to a lower risk of type 2 diabetes, independent of the presence of obesity
title_full Healthy dietary pattern and their corresponding gut microbiota profile are linked to a lower risk of type 2 diabetes, independent of the presence of obesity
title_fullStr Healthy dietary pattern and their corresponding gut microbiota profile are linked to a lower risk of type 2 diabetes, independent of the presence of obesity
title_full_unstemmed Healthy dietary pattern and their corresponding gut microbiota profile are linked to a lower risk of type 2 diabetes, independent of the presence of obesity
title_sort Healthy dietary pattern and their corresponding gut microbiota profile are linked to a lower risk of type 2 diabetes, independent of the presence of obesity
dc.creator.none.fl_str_mv Díaz Rizzolo, Diana A
Kostov, Belchin
López Siles, Mireia
Serra, Assumpta
Colungo, Cristina
González de Paz, Luis
Martínez Medina, Margarita
Sisó Almirall, Antoni
Gomis, Ramon
author Díaz Rizzolo, Diana A
author_facet Díaz Rizzolo, Diana A
Kostov, Belchin
López Siles, Mireia
Serra, Assumpta
Colungo, Cristina
González de Paz, Luis
Martínez Medina, Margarita
Sisó Almirall, Antoni
Gomis, Ramon
author_role author
author2 Kostov, Belchin
López Siles, Mireia
Serra, Assumpta
Colungo, Cristina
González de Paz, Luis
Martínez Medina, Margarita
Sisó Almirall, Antoni
Gomis, Ramon
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Universitat de Girona
Universitat Oberta de Catalunya (UOC)
dc.subject.none.fl_str_mv diet
microbiota
diabetes
nutrition
prevention
obesity
dieta
microbiota
diabetis
nutrició
prevenció
obesitat
dieta
microbiota
diabetes
nutrición
prevención
obesidad
Diabetes -- Nutrional aspects
Diabetis -- Aspectes nutricionals
Diabetes -- Aspectos nutricionales
topic diet
microbiota
diabetes
nutrition
prevention
obesity
dieta
microbiota
diabetis
nutrició
prevenció
obesitat
dieta
microbiota
diabetes
nutrición
prevención
obesidad
Diabetes -- Nutrional aspects
Diabetis -- Aspectes nutricionals
Diabetes -- Aspectos nutricionales
description Background: Prediabetes and old age are both high risk factors for developing Type 2 Diabetes (T2D), while obesity is one of the most important factors triggering the disease. Nutritional interventions are the most effective tool for preventing T2D, as they improve different biochemical and anthropometric outcomes and growth-promoting/inhibiting gut microbiota populations. However, to date there are no specific dietary recommendations to stop the development of T2D in elderly groups, for whom hypocaloric diets and other commonly used weight-loss programs could be considered dangerous. The objective of our study, thus, was to understand the impact of dietary patterns on T2D risk as related to gut microbiota profile in obese and non-obese elderly prediabetic subjects. Methods: A cross-sectional study was performed in 182 subjects >65 years old with prediabetes, divided into obese (OB) or non-obese (NOB) subgroups, and their risk of developing T2D was measured according to FINDRISK score and biochemical parameters. Also, clusters into different dietary patterns in each group by PCA analysis was related with gut microbiota, which was analyzed from stool samples by qPCR. The creation of clusters was used to re-evaluate T2D risk. Results: OB was at higher risk of developing T2D and showed worse metabolic outcomes. Unhealthier and healthier dietary pattern clusters were observed for both OB (OB-6 and OB-5 respectively) and NOB (NOB-2 and NOB-3 respectively) groups. Results obtained from the gut microbiota showed that only Prevotella was higher in NOB, but when comparisons were made between clusters, a clear relation with dietary pattern was observed; showing in healthier dietary clusters a decrease in Prevotella, an increase of Faecalibacterium prausnitzii and an increase in lactic acid bacteria. T2D risk was greater in the obese group between unhealthier dietary clusters. No difference between healthier dietary clusters was observed. Conclusion: A healthy dietary pattern and the growth-promoting beneficial and growth-inhibiting disadvantageous gut microbiota populations linked to it provide protection against the development of T2D in an obese population with advanced age and preDM.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10609/103286
url https://hdl.handle.net/10609/103286
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Clinical Nutrition, 2020, 39(2)
https://doi.org/10.1016/j.clnu.2019.02.035
dc.rights.none.fl_str_mv CC BY-NC-ND
http://creativecommons.org/licenses/by-nc-nd/4.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC BY-NC-ND
http://creativecommons.org/licenses/by-nc-nd/4.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Clinical Nutrition
publisher.none.fl_str_mv Clinical Nutrition
dc.source.none.fl_str_mv reponame:O2, repositorio institucional de la UOC
instname:Universitat Oberta de Catalunya (UOC)
instname_str Universitat Oberta de Catalunya (UOC)
reponame_str O2, repositorio institucional de la UOC
collection O2, repositorio institucional de la UOC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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