Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancer: a HuGE-GSEC review

The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database...

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Detalles Bibliográficos
Autores: Varela Lema, María Leonor, Taioli, Emanuela, Ruano Raviña, Alberto, Barros Dios, Juan Miguel, Anantharaman, Devasena, Benhamou, Simone, Boccia, Stefania, Bhisey, Rajani A., Cadoni, Gabriella, Capoluongo, Ettore, Chen, Chien-Jen, Foulkes, William D., Goloni Bertollo, Eny Maria, Hatagima, Ana, Hayes, Richard B., Katoh, Takahiko, Koifman, Sergio, Lazarus, Phillip, Manni, Johannes J., Mahimkar, Manoj, Morita, Shunji, Park, Jong, Park, Kwang-Kyun, Pavarino Bertelli, Erika Cristina, Ribeiro, Enilze Maria de Souza Fonseca, Roy, Bidyut, Spitz, Margaret R., Strange, Richard C., Wei, Qingyi, Ragin, Camille C.
Tipo de recurso: artículo
Fecha de publicación:2008
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/13418
Acceso en línea:http://hdl.handle.net/10347/13418
Access Level:acceso abierto
Palabra clave:Materias::Investigación::32 Ciencias médicas::3202 Epidemologia
Materias::Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320102 Genética clínica
Descripción
Sumario:The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/index.html ). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The meta-analysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-ORm2/m2: 1.9, 95% confidence interval: 1.4-2.7; Pooled ORm2m2: 2.0, 95% confidence interval: 1.3-3.1; ORm1m2 or [infi]m2m2: 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (ORVal/Val: 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer.

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