Influence of consumption of two Peruvian cocoa populations on mucosal and systemic immune response in an allergic asthma rat model

Different cocoa populations have demonstrated a protective role in a rat model of allergic asthma by attenuating the immunoglobulin (Ig) E synthesis and partially protecting against anaphylactic response. The aim of this study was to ascertain the effect of diets containing two native Peruvian cocoa...

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Autores: Périz, Marta, Rodríguez Lagunas, María José, Pérez-Cano, Francisco J., Best, Iván, Pastor Soplín, Santiago, Castell, Margarida, Massot Cladera, Malen
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/185879
Acceso en línea:https://hdl.handle.net/2445/185879
Access Level:acceso abierto
Palabra clave:Cacau
Asma
Al·lèrgia
Cocoa
Asthma
Allergy
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spelling Influence of consumption of two Peruvian cocoa populations on mucosal and systemic immune response in an allergic asthma rat modelPériz, MartaRodríguez Lagunas, María JoséPérez-Cano, Francisco J.Best, IvánPastor Soplín, SantiagoCastell, MargaridaMassot Cladera, MalenCacauAsmaAl·lèrgiaCocoaAsthmaAllergyDifferent cocoa populations have demonstrated a protective role in a rat model of allergic asthma by attenuating the immunoglobulin (Ig) E synthesis and partially protecting against anaphylactic response. The aim of this study was to ascertain the effect of diets containing two native Peruvian cocoa populations ("Amazonas Peru" or APC, and "Criollo de Montaña" or CMC) and an ordinary cocoa (OC) on the bronchial compartment and the systemic and mucosal immune system in the same rat model of allergic asthma. Among other variables, cells and IgA content in the bronchoalveolar lavage fluid (BALF) and serum anti-allergen antibody response were analyzed. The three cocoa populations prevented the increase of the serum specific IgG1 (T helper 2 isotype). The three cocoa diets decreased asthma-induced granulocyte increase in the BALF, which was mainly due to the reduction in the proportion of eosinophils. Moreover, both the OC and CMC diets were able to prevent the leukocyte infiltration caused by asthma induction in both the trachea and nasal cavity and decreased the IgA in both fecal and BALF samples. Overall, these results highlight the potential of different cocoa populations in the prevention of allergic asthma.MDPI2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/185879Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/nu14030410Nutrients, 2022, vol. 14, p. 410https://doi.org/10.3390/nu14030410cc-by (c) Périz, Marta et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1858792026-05-29T05:05:01Z
dc.title.none.fl_str_mv Influence of consumption of two Peruvian cocoa populations on mucosal and systemic immune response in an allergic asthma rat model
title Influence of consumption of two Peruvian cocoa populations on mucosal and systemic immune response in an allergic asthma rat model
spellingShingle Influence of consumption of two Peruvian cocoa populations on mucosal and systemic immune response in an allergic asthma rat model
Périz, Marta
Cacau
Asma
Al·lèrgia
Cocoa
Asthma
Allergy
title_short Influence of consumption of two Peruvian cocoa populations on mucosal and systemic immune response in an allergic asthma rat model
title_full Influence of consumption of two Peruvian cocoa populations on mucosal and systemic immune response in an allergic asthma rat model
title_fullStr Influence of consumption of two Peruvian cocoa populations on mucosal and systemic immune response in an allergic asthma rat model
title_full_unstemmed Influence of consumption of two Peruvian cocoa populations on mucosal and systemic immune response in an allergic asthma rat model
title_sort Influence of consumption of two Peruvian cocoa populations on mucosal and systemic immune response in an allergic asthma rat model
dc.creator.none.fl_str_mv Périz, Marta
Rodríguez Lagunas, María José
Pérez-Cano, Francisco J.
Best, Iván
Pastor Soplín, Santiago
Castell, Margarida
Massot Cladera, Malen
author Périz, Marta
author_facet Périz, Marta
Rodríguez Lagunas, María José
Pérez-Cano, Francisco J.
Best, Iván
Pastor Soplín, Santiago
Castell, Margarida
Massot Cladera, Malen
author_role author
author2 Rodríguez Lagunas, María José
Pérez-Cano, Francisco J.
Best, Iván
Pastor Soplín, Santiago
Castell, Margarida
Massot Cladera, Malen
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Cacau
Asma
Al·lèrgia
Cocoa
Asthma
Allergy
topic Cacau
Asma
Al·lèrgia
Cocoa
Asthma
Allergy
description Different cocoa populations have demonstrated a protective role in a rat model of allergic asthma by attenuating the immunoglobulin (Ig) E synthesis and partially protecting against anaphylactic response. The aim of this study was to ascertain the effect of diets containing two native Peruvian cocoa populations ("Amazonas Peru" or APC, and "Criollo de Montaña" or CMC) and an ordinary cocoa (OC) on the bronchial compartment and the systemic and mucosal immune system in the same rat model of allergic asthma. Among other variables, cells and IgA content in the bronchoalveolar lavage fluid (BALF) and serum anti-allergen antibody response were analyzed. The three cocoa populations prevented the increase of the serum specific IgG1 (T helper 2 isotype). The three cocoa diets decreased asthma-induced granulocyte increase in the BALF, which was mainly due to the reduction in the proportion of eosinophils. Moreover, both the OC and CMC diets were able to prevent the leukocyte infiltration caused by asthma induction in both the trachea and nasal cavity and decreased the IgA in both fecal and BALF samples. Overall, these results highlight the potential of different cocoa populations in the prevention of allergic asthma.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/185879
url https://hdl.handle.net/2445/185879
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nu14030410
Nutrients, 2022, vol. 14, p. 410
https://doi.org/10.3390/nu14030410
dc.rights.none.fl_str_mv cc-by (c) Périz, Marta et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Périz, Marta et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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