Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia—Extracellular Matrix Proteins and TGF-β1 Immunoexpression

Feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) has been described as an inflammatory disorder with an eosinophilic component with etiopathogenesis that is still unknown. Sixteen intestinal samples from two veterinary diagnostic services (2014–2017) were included in the study. A...

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Autores: Porras, Néstor, Rebollada Merino, Agustín Miguel, Rodríguez Franco, Fernando, Calvo-Ibbitson, Andrés, Rodríguez Bertos, Antonio Manuel
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/95657
Acceso en línea:https://hdl.handle.net/20.500.14352/95657
Access Level:acceso abierto
Palabra clave:Collagen
Feline gastrointestinal eosinophilic sclerosing fibroplasia
Fibronectin
Intestinal fibrosis
Immunohistochemistry
TGF-β1
Ciencias Biomédicas
Veterinaria
Patología veterinaria
3109 Ciencias Veterinarias
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spelling Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia—Extracellular Matrix Proteins and TGF-β1 ImmunoexpressionPorras, NéstorRebollada Merino, Agustín MiguelRodríguez Franco, FernandoCalvo-Ibbitson, AndrésRodríguez Bertos, Antonio ManuelCollagenFeline gastrointestinal eosinophilic sclerosing fibroplasiaFibronectinIntestinal fibrosisImmunohistochemistryTGF-β1Ciencias BiomédicasVeterinariaPatología veterinaria3109 Ciencias VeterinariasFeline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) has been described as an inflammatory disorder with an eosinophilic component with etiopathogenesis that is still unknown. Sixteen intestinal samples from two veterinary diagnostic services (2014–2017) were included in the study. A histopathological criterion classified the cases into three grades (mild, moderate, and severe) according to the distribution of the lesions and the course. An immunohistochemical study of collagen I, collagen III, fibronectin, and transforming growth factor β1 (TGF-β1) was performed in each case. An immunohistochemical study of mild grades shows greater collagen III immunoexpression, compared to collagen I and fibronectin, which suggests an “early” stage of fibrosis. In more intense grades, an increased immunoexpression of collagen I, compared to collagen III, suggests a “late” stage of fibrosis. Otherwise, the highest expression of TGF-β1 was observed in the moderate phase, due to the high proliferation of reactive fibroblast and intense inflammation. The results suggest that the inflammatory infiltrate is the trigger for the elevation in TGF-β1, altering the collagen type III:I ratio. In conclusion, immunohistochemical studies can be a very useful method in diagnosing cases of FGESF of mild grades and could help to apply a differential diagnosis regarding feline eosinophilic chronic enteritis (CEE) in the context of inflammatory bowel disease (IBD).MDPIUniversidad Complutense de Madrid20222022-06-1320222022-06-13journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/95657reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/956572026-06-02T12:44:21Z
dc.title.none.fl_str_mv Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia—Extracellular Matrix Proteins and TGF-β1 Immunoexpression
title Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia—Extracellular Matrix Proteins and TGF-β1 Immunoexpression
spellingShingle Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia—Extracellular Matrix Proteins and TGF-β1 Immunoexpression
Porras, Néstor
Collagen
Feline gastrointestinal eosinophilic sclerosing fibroplasia
Fibronectin
Intestinal fibrosis
Immunohistochemistry
TGF-β1
Ciencias Biomédicas
Veterinaria
Patología veterinaria
3109 Ciencias Veterinarias
title_short Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia—Extracellular Matrix Proteins and TGF-β1 Immunoexpression
title_full Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia—Extracellular Matrix Proteins and TGF-β1 Immunoexpression
title_fullStr Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia—Extracellular Matrix Proteins and TGF-β1 Immunoexpression
title_full_unstemmed Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia—Extracellular Matrix Proteins and TGF-β1 Immunoexpression
title_sort Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia—Extracellular Matrix Proteins and TGF-β1 Immunoexpression
dc.creator.none.fl_str_mv Porras, Néstor
Rebollada Merino, Agustín Miguel
Rodríguez Franco, Fernando
Calvo-Ibbitson, Andrés
Rodríguez Bertos, Antonio Manuel
author Porras, Néstor
author_facet Porras, Néstor
Rebollada Merino, Agustín Miguel
Rodríguez Franco, Fernando
Calvo-Ibbitson, Andrés
Rodríguez Bertos, Antonio Manuel
author_role author
author2 Rebollada Merino, Agustín Miguel
Rodríguez Franco, Fernando
Calvo-Ibbitson, Andrés
Rodríguez Bertos, Antonio Manuel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Collagen
Feline gastrointestinal eosinophilic sclerosing fibroplasia
Fibronectin
Intestinal fibrosis
Immunohistochemistry
TGF-β1
Ciencias Biomédicas
Veterinaria
Patología veterinaria
3109 Ciencias Veterinarias
topic Collagen
Feline gastrointestinal eosinophilic sclerosing fibroplasia
Fibronectin
Intestinal fibrosis
Immunohistochemistry
TGF-β1
Ciencias Biomédicas
Veterinaria
Patología veterinaria
3109 Ciencias Veterinarias
description Feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) has been described as an inflammatory disorder with an eosinophilic component with etiopathogenesis that is still unknown. Sixteen intestinal samples from two veterinary diagnostic services (2014–2017) were included in the study. A histopathological criterion classified the cases into three grades (mild, moderate, and severe) according to the distribution of the lesions and the course. An immunohistochemical study of collagen I, collagen III, fibronectin, and transforming growth factor β1 (TGF-β1) was performed in each case. An immunohistochemical study of mild grades shows greater collagen III immunoexpression, compared to collagen I and fibronectin, which suggests an “early” stage of fibrosis. In more intense grades, an increased immunoexpression of collagen I, compared to collagen III, suggests a “late” stage of fibrosis. Otherwise, the highest expression of TGF-β1 was observed in the moderate phase, due to the high proliferation of reactive fibroblast and intense inflammation. The results suggest that the inflammatory infiltrate is the trigger for the elevation in TGF-β1, altering the collagen type III:I ratio. In conclusion, immunohistochemical studies can be a very useful method in diagnosing cases of FGESF of mild grades and could help to apply a differential diagnosis regarding feline eosinophilic chronic enteritis (CEE) in the context of inflammatory bowel disease (IBD).
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-06-13
2022
2022-06-13
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/95657
url https://hdl.handle.net/20.500.14352/95657
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405518654603264
score 15.301629

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