Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms

Background: Cocaine-induced psychosis (CIP) is among the most serious adverse effects of cocaine. Reduced serum brain-derived neurotrophic factor (BDNF) levels have been reported in schizophrenia and psychosis; however, studies assessing the involvement of BDNF in CIP are lacking. Methods: A total o...

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Detalles Bibliográficos
Autores: Corominas-Roso, Margarida, Roncero, Carlos, Eiroá Orosa, Francisco José, Ribasés Haro, Marta, Barral, Carmen, Daigre, Constanza, Martínez-Luna, Nieves, Sánchez Mora, Cristina, Ramos Quiroga, Josep Antoni, Casas, Miquel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2013
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/119392
Acceso en línea:https://hdl.handle.net/2445/119392
Access Level:acceso abierto
Palabra clave:Cocaïna
Drogoaddicció
Psicosi
Cocaine
Drug addiction
Psychoses
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spelling Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptomsCorominas-Roso, MargaridaRoncero, CarlosEiroá Orosa, Francisco JoséRibasés Haro, MartaBarral, CarmenDaigre, ConstanzaMartínez-Luna, NievesSánchez Mora, CristinaRamos Quiroga, Josep AntoniCasas, MiquelCocaïnaDrogoaddiccióPsicosiCocaineDrug addictionPsychosesBackground: Cocaine-induced psychosis (CIP) is among the most serious adverse effects of cocaine. Reduced serum brain-derived neurotrophic factor (BDNF) levels have been reported in schizophrenia and psychosis; however, studies assessing the involvement of BDNF in CIP are lacking. Methods: A total of 22 cocaine-dependent patients (aged 33.65 ± 6.85) who had never experienced psychotic symptoms under the influence of cocaine (non-CIP) and 18 patients (aged 34.18 ± 8.54) with a history of CIP completed a 2-week detoxification program in an inpatient facility. Two serum samples were collected from each patient at baseline and at the end of the protocol. Demographic, consumption and clinical data were recorded for all patients. A paired group of healthy controls was also included. Results: At the beginning of the detoxification treatment, serum BDNF levels were similar in both the non-CIP and the CIP groups. During early abstinence, the non-CIP group exhibited a significant increase in serum BDNF levels (p = 0.030), whereas the CIP group exhibited a decrease. Improvements in depression (Beck Depression Inventory, BDI, p = 0.003) and withdrawal symptoms (Cocaine Selective Severity Assessment, CSSA, p = 0.013) show a significant positive correlation with serum BDNF levels in the non-CIP group, whereas no correlation between the same variables was found in the CIP group. Conclusions: This study suggests that BDNF plays a role in the transient psychotic symptoms associated with cocaine consumption. In the non-CIP group, the increase in serum BDNF appears to be driven by the effects of chronic cocaine consumption and withdrawal. In contrast, patients with CIP share some of the neurotrophic deficiencies that characterize schizophrenia and psychosis.Karger2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/119392Articles publicats en revistes (Psicologia Clínica i Psicobiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1159/000353259Neuropsychobiology, 2013, vol. 68, num. 3, p. 146-155https://doi.org/10.1159/000353259(c) Karger, 2013info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1193922026-05-27T06:46:51Z
dc.title.none.fl_str_mv Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms
title Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms
spellingShingle Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms
Corominas-Roso, Margarida
Cocaïna
Drogoaddicció
Psicosi
Cocaine
Drug addiction
Psychoses
title_short Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms
title_full Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms
title_fullStr Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms
title_full_unstemmed Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms
title_sort Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms
dc.creator.none.fl_str_mv Corominas-Roso, Margarida
Roncero, Carlos
Eiroá Orosa, Francisco José
Ribasés Haro, Marta
Barral, Carmen
Daigre, Constanza
Martínez-Luna, Nieves
Sánchez Mora, Cristina
Ramos Quiroga, Josep Antoni
Casas, Miquel
author Corominas-Roso, Margarida
author_facet Corominas-Roso, Margarida
Roncero, Carlos
Eiroá Orosa, Francisco José
Ribasés Haro, Marta
Barral, Carmen
Daigre, Constanza
Martínez-Luna, Nieves
Sánchez Mora, Cristina
Ramos Quiroga, Josep Antoni
Casas, Miquel
author_role author
author2 Roncero, Carlos
Eiroá Orosa, Francisco José
Ribasés Haro, Marta
Barral, Carmen
Daigre, Constanza
Martínez-Luna, Nieves
Sánchez Mora, Cristina
Ramos Quiroga, Josep Antoni
Casas, Miquel
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cocaïna
Drogoaddicció
Psicosi
Cocaine
Drug addiction
Psychoses
topic Cocaïna
Drogoaddicció
Psicosi
Cocaine
Drug addiction
Psychoses
description Background: Cocaine-induced psychosis (CIP) is among the most serious adverse effects of cocaine. Reduced serum brain-derived neurotrophic factor (BDNF) levels have been reported in schizophrenia and psychosis; however, studies assessing the involvement of BDNF in CIP are lacking. Methods: A total of 22 cocaine-dependent patients (aged 33.65 ± 6.85) who had never experienced psychotic symptoms under the influence of cocaine (non-CIP) and 18 patients (aged 34.18 ± 8.54) with a history of CIP completed a 2-week detoxification program in an inpatient facility. Two serum samples were collected from each patient at baseline and at the end of the protocol. Demographic, consumption and clinical data were recorded for all patients. A paired group of healthy controls was also included. Results: At the beginning of the detoxification treatment, serum BDNF levels were similar in both the non-CIP and the CIP groups. During early abstinence, the non-CIP group exhibited a significant increase in serum BDNF levels (p = 0.030), whereas the CIP group exhibited a decrease. Improvements in depression (Beck Depression Inventory, BDI, p = 0.003) and withdrawal symptoms (Cocaine Selective Severity Assessment, CSSA, p = 0.013) show a significant positive correlation with serum BDNF levels in the non-CIP group, whereas no correlation between the same variables was found in the CIP group. Conclusions: This study suggests that BDNF plays a role in the transient psychotic symptoms associated with cocaine consumption. In the non-CIP group, the increase in serum BDNF appears to be driven by the effects of chronic cocaine consumption and withdrawal. In contrast, patients with CIP share some of the neurotrophic deficiencies that characterize schizophrenia and psychosis.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/119392
url https://hdl.handle.net/2445/119392
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1159/000353259
Neuropsychobiology, 2013, vol. 68, num. 3, p. 146-155
https://doi.org/10.1159/000353259
dc.rights.none.fl_str_mv (c) Karger, 2013
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Karger, 2013
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv Articles publicats en revistes (Psicologia Clínica i Psicobiologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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