Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients
Background: The relative contribution of the different components of mechanical power to mortality is a subject of debate and has not been studied in COVID-19. The aim of this study is to evaluate both the total and the relative impact of each of the components of mechanical power on mortality in a...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/221707 |
| Acceso en línea: | https://hdl.handle.net/2445/221707 |
| Access Level: | acceso abierto |
| Palabra clave: | COVID-19 Respiració artificial Respiradors Artificial respiration Respirators |
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Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patientsBarbeta, EnricBarreiros, ClaudiaForin, EdoardoGuzzardella, AmedeoMotos, AnaFernández Barat, LaiaGabarrús, AlbertCeccato, AdrianFerrer i Roig, RuthRiera, JordiPeñuelas, OscarLorente, José AngelGonzalo-Calvo, David deGonzález, JessicaAmaya Villar, RosarioAñón, José M.Balan, AnaBarberà, CarmeBarberán, JoséBlandino Ortiz, AaronBoado Varela, Maria VictoriaBustamante Munguira, ElenaCaballero, JesúsCanton-Bulnes, María L.Carbajales Pérez, CristinaCarbonell, NievesCatalán González, MercedesFranco, NievesGalbán, CristóbalGumucio Sanguino, Víctor D.De La Torre, Maria Del CarmenDiaz, EmiliEstella, ÁngelGallego, ElenaGomez, José ManuelHuerta, ArturoJorge García, Ruth NoemíLoza Vázquez, AnaMarin Corral, JudithMartín Delgado, María CruzMartínez, AmaliaMartínez, IgnacioLópez, JuanAlbaiceta, Guillermo M.Nieto, María TeresaNovo, Mariana AndreaPeñasco, YhivianPérez-García, FelipeRicart, PilarRodríguez, AlejandroSagredo, VíctorSánchez Miralles, ÁngelSancho, SusanaRoche Campo, FerranSocias, LorenzoSolé Violán, JordiTamayo Lomas, LuisTrenado, JosepÚbeda, AlejandroValdivia, Luis JorgeVidal, PabloBarbe, FerranVallverdú, JordiTorres Martí, AntoniCOVID-19Respiració artificialRespiradorsCOVID-19Artificial respirationRespiratorsBackground: The relative contribution of the different components of mechanical power to mortality is a subject of debate and has not been studied in COVID-19. The aim of this study is to evaluate both the total and the relative impact of each of the components of mechanical power on mortality in a well-characterized cohort of patients with COVID-19-induced acute respiratory failure undergoing invasive mechanical ventilation. This is a secondary analysis of the CIBERESUCICOVID project, a multicenter observational cohort study including fifty Spanish intensive care units that included COVID-19 mechanically ventilated patients between February 2020 and December 2021. We examined the association between mechanical power and its components (elastic static, elastic dynamic, total elastic and resistive power) with 90-day mortality after adjusting for confounders in seven hundred ninety-nine patients with COVID-19-induced respiratory failure undergoing invasive mechanical ventilation. Results: At the initiation of mechanical ventilation, the PaO2/FiO2 ratio was 106 (78; 150), ventilatory ratio was 1.69 (1.40; 2.05), and respiratory system compliance was 35.7 (29.2; 44.5) ml/cmH2O. Mechanical power at the initiation of mechanical ventilation was 24.3 (18.9; 29.6) J/min, showing no significant changes after three days. In multivariable regression analyses, mechanical power and its components were not associated with 90-day mortality at the start of mechanical ventilation. After three days, total elastic and elastic static power were associated with higher 90-day mortality, but this relationship was also found for positive end-expiratory pressure. Conclusions: Neither mechanical power nor its components were independently associated with mortality in COVID-19-induced acute respiratory failure at the start of MV. Nevertheless, after three days, static elastic power and total elastic power were associated with lower odds of survival. Positive end-expiratory pressure and plateau pressure, however, captured this risk in a similar manner. Keywords: COVID-19; Mechanical power; Mechanical ventilation; Respiratory failure.SpringerOpen2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/221707Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1186/s13613-025-01430-6Annals of Intensive Care, 2025, vol. 15, num.1https://doi.org/10.1186/s13613-025-01430-6cc-by (c) Enric Barbeta, et al., 2025http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2217072026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients |
| title |
Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients |
| spellingShingle |
Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients Barbeta, Enric COVID-19 Respiració artificial Respiradors COVID-19 Artificial respiration Respirators |
| title_short |
Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients |
| title_full |
Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients |
| title_fullStr |
Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients |
| title_full_unstemmed |
Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients |
| title_sort |
Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients |
| dc.creator.none.fl_str_mv |
Barbeta, Enric Barreiros, Claudia Forin, Edoardo Guzzardella, Amedeo Motos, Ana Fernández Barat, Laia Gabarrús, Albert Ceccato, Adrian Ferrer i Roig, Ruth Riera, Jordi Peñuelas, Oscar Lorente, José Angel Gonzalo-Calvo, David de González, Jessica Amaya Villar, Rosario Añón, José M. Balan, Ana Barberà, Carme Barberán, José Blandino Ortiz, Aaron Boado Varela, Maria Victoria Bustamante Munguira, Elena Caballero, Jesús Canton-Bulnes, María L. Carbajales Pérez, Cristina Carbonell, Nieves Catalán González, Mercedes Franco, Nieves Galbán, Cristóbal Gumucio Sanguino, Víctor D. De La Torre, Maria Del Carmen Diaz, Emili Estella, Ángel Gallego, Elena Gomez, José Manuel Huerta, Arturo Jorge García, Ruth Noemí Loza Vázquez, Ana Marin Corral, Judith Martín Delgado, María Cruz Martínez, Amalia Martínez, Ignacio López, Juan Albaiceta, Guillermo M. Nieto, María Teresa Novo, Mariana Andrea Peñasco, Yhivian Pérez-García, Felipe Ricart, Pilar Rodríguez, Alejandro Sagredo, Víctor Sánchez Miralles, Ángel Sancho, Susana Roche Campo, Ferran Socias, Lorenzo Solé Violán, Jordi Tamayo Lomas, Luis Trenado, Josep Úbeda, Alejandro Valdivia, Luis Jorge Vidal, Pablo Barbe, Ferran Vallverdú, Jordi Torres Martí, Antoni |
| author |
Barbeta, Enric |
| author_facet |
Barbeta, Enric Barreiros, Claudia Forin, Edoardo Guzzardella, Amedeo Motos, Ana Fernández Barat, Laia Gabarrús, Albert Ceccato, Adrian Ferrer i Roig, Ruth Riera, Jordi Peñuelas, Oscar Lorente, José Angel Gonzalo-Calvo, David de González, Jessica Amaya Villar, Rosario Añón, José M. Balan, Ana Barberà, Carme Barberán, José Blandino Ortiz, Aaron Boado Varela, Maria Victoria Bustamante Munguira, Elena Caballero, Jesús Canton-Bulnes, María L. Carbajales Pérez, Cristina Carbonell, Nieves Catalán González, Mercedes Franco, Nieves Galbán, Cristóbal Gumucio Sanguino, Víctor D. De La Torre, Maria Del Carmen Diaz, Emili Estella, Ángel Gallego, Elena Gomez, José Manuel Huerta, Arturo Jorge García, Ruth Noemí Loza Vázquez, Ana Marin Corral, Judith Martín Delgado, María Cruz Martínez, Amalia Martínez, Ignacio López, Juan Albaiceta, Guillermo M. Nieto, María Teresa Novo, Mariana Andrea Peñasco, Yhivian Pérez-García, Felipe Ricart, Pilar Rodríguez, Alejandro Sagredo, Víctor Sánchez Miralles, Ángel Sancho, Susana Roche Campo, Ferran Socias, Lorenzo Solé Violán, Jordi Tamayo Lomas, Luis Trenado, Josep Úbeda, Alejandro Valdivia, Luis Jorge Vidal, Pablo Barbe, Ferran Vallverdú, Jordi Torres Martí, Antoni |
| author_role |
author |
| author2 |
Barreiros, Claudia Forin, Edoardo Guzzardella, Amedeo Motos, Ana Fernández Barat, Laia Gabarrús, Albert Ceccato, Adrian Ferrer i Roig, Ruth Riera, Jordi Peñuelas, Oscar Lorente, José Angel Gonzalo-Calvo, David de González, Jessica Amaya Villar, Rosario Añón, José M. Balan, Ana Barberà, Carme Barberán, José Blandino Ortiz, Aaron Boado Varela, Maria Victoria Bustamante Munguira, Elena Caballero, Jesús Canton-Bulnes, María L. Carbajales Pérez, Cristina Carbonell, Nieves Catalán González, Mercedes Franco, Nieves Galbán, Cristóbal Gumucio Sanguino, Víctor D. De La Torre, Maria Del Carmen Diaz, Emili Estella, Ángel Gallego, Elena Gomez, José Manuel Huerta, Arturo Jorge García, Ruth Noemí Loza Vázquez, Ana Marin Corral, Judith Martín Delgado, María Cruz Martínez, Amalia Martínez, Ignacio López, Juan Albaiceta, Guillermo M. Nieto, María Teresa Novo, Mariana Andrea Peñasco, Yhivian Pérez-García, Felipe Ricart, Pilar Rodríguez, Alejandro Sagredo, Víctor Sánchez Miralles, Ángel Sancho, Susana Roche Campo, Ferran Socias, Lorenzo Solé Violán, Jordi Tamayo Lomas, Luis Trenado, Josep Úbeda, Alejandro Valdivia, Luis Jorge Vidal, Pablo Barbe, Ferran Vallverdú, Jordi Torres Martí, Antoni |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
COVID-19 Respiració artificial Respiradors COVID-19 Artificial respiration Respirators |
| topic |
COVID-19 Respiració artificial Respiradors COVID-19 Artificial respiration Respirators |
| description |
Background: The relative contribution of the different components of mechanical power to mortality is a subject of debate and has not been studied in COVID-19. The aim of this study is to evaluate both the total and the relative impact of each of the components of mechanical power on mortality in a well-characterized cohort of patients with COVID-19-induced acute respiratory failure undergoing invasive mechanical ventilation. This is a secondary analysis of the CIBERESUCICOVID project, a multicenter observational cohort study including fifty Spanish intensive care units that included COVID-19 mechanically ventilated patients between February 2020 and December 2021. We examined the association between mechanical power and its components (elastic static, elastic dynamic, total elastic and resistive power) with 90-day mortality after adjusting for confounders in seven hundred ninety-nine patients with COVID-19-induced respiratory failure undergoing invasive mechanical ventilation. Results: At the initiation of mechanical ventilation, the PaO2/FiO2 ratio was 106 (78; 150), ventilatory ratio was 1.69 (1.40; 2.05), and respiratory system compliance was 35.7 (29.2; 44.5) ml/cmH2O. Mechanical power at the initiation of mechanical ventilation was 24.3 (18.9; 29.6) J/min, showing no significant changes after three days. In multivariable regression analyses, mechanical power and its components were not associated with 90-day mortality at the start of mechanical ventilation. After three days, total elastic and elastic static power were associated with higher 90-day mortality, but this relationship was also found for positive end-expiratory pressure. Conclusions: Neither mechanical power nor its components were independently associated with mortality in COVID-19-induced acute respiratory failure at the start of MV. Nevertheless, after three days, static elastic power and total elastic power were associated with lower odds of survival. Positive end-expiratory pressure and plateau pressure, however, captured this risk in a similar manner. Keywords: COVID-19; Mechanical power; Mechanical ventilation; Respiratory failure. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/221707 |
| url |
https://hdl.handle.net/2445/221707 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1186/s13613-025-01430-6 Annals of Intensive Care, 2025, vol. 15, num.1 https://doi.org/10.1186/s13613-025-01430-6 |
| dc.rights.none.fl_str_mv |
cc-by (c) Enric Barbeta, et al., 2025 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by (c) Enric Barbeta, et al., 2025 http://creativecommons.org/licenses/by/3.0/es/ |
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openAccess |
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application/pdf |
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SpringerOpen |
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SpringerOpen |
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Articles publicats en revistes (Bioquímica i Fisiologia) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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15,812429 |