What is the status of immunotherapy in thyroid neoplasms?
Immunotherapy; Thyroid neoplasms; Tumor mutational burden
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/8342 |
| Acceso en línea: | https://hdl.handle.net/11351/8342 |
| Access Level: | acceso abierto |
| Palabra clave: | Tiroide - Càncer - Tractament Immunoteràpia ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy DISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Thyroid Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias de la tiroides Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia |
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What is the status of immunotherapy in thyroid neoplasms?Garcia Alvarez, AlejandroHernando Cubero, JorgeCarmona Alonso, AnaCapdevila Castillon, JaumeTiroide - Càncer - TractamentImmunoteràpiaANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::ImmunotherapyDISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Thyroid NeoplasmsOther subheadings::Other subheadings::Other subheadings::/drug therapyTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapiaENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias de la tiroidesOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaImmunotherapy; Thyroid neoplasms; Tumor mutational burdenInmunoterapia; Neoplasias de la tiroides; Carga mutacional tumoralImmunoteràpia; Neoplàsies de les tiroides; Càrrega mutacional tumoralImmunotherapy has changed the treatment of patients with advanced cancer, with different phase III trials showing durable responses across different histologies. This review focuses on the preclinical and clinical evidence of potential predictive biomarkers of response and efficacy of immunotherapy in thyroid neoplasms. Programmed death-ligand 1 (PD-L1) staining by immunohistochemistry has shown higher expression in anaplastic thyroid cancer (ATC) compared to other subtypes. The tumor mutational burden in thyroid neoplasms is low but seems to be higher in ATC. Immune infiltrates in the tumor microenvironment (TME) differ between the different thyroid neoplasm subtypes. In general, differentiated thyroid cancer (DTC) has a higher number of tumor-associated lymphocytes and regulatory T cells (Tregs), while ATC and medullary thyroid cancer (MTC) display a high density of tumor-associated macrophages (TAMs). Nevertheless, results from clinical trials with immunotherapy as monotherapy or combinations have shown limited efficacy. Further investigation into new strategies aside from anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4)/programmed death 1 (PD-1)/PD-L1 antibodies, validation of predictive biomarkers, and better population selection for clinical trials in thyroid neoplasms is more than needed in the near future.Frontiers MediaInstitut Català de la Salut[Garcia-Alvarez A, Hernando J, Carmona-Alonso A, Capdevila J] Unitat de Tumors Gastrointestinals i Endocrins, Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall Hebron Institute of Oncology (VHIO), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8342Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésFrontiers in Endocrinology;13https://doi.org/10.3389/fendo.2022.929091Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/83422026-06-12T09:38:37Z |
| dc.title.none.fl_str_mv |
What is the status of immunotherapy in thyroid neoplasms? |
| title |
What is the status of immunotherapy in thyroid neoplasms? |
| spellingShingle |
What is the status of immunotherapy in thyroid neoplasms? Garcia Alvarez, Alejandro Tiroide - Càncer - Tractament Immunoteràpia ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy DISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Thyroid Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias de la tiroides Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia |
| title_short |
What is the status of immunotherapy in thyroid neoplasms? |
| title_full |
What is the status of immunotherapy in thyroid neoplasms? |
| title_fullStr |
What is the status of immunotherapy in thyroid neoplasms? |
| title_full_unstemmed |
What is the status of immunotherapy in thyroid neoplasms? |
| title_sort |
What is the status of immunotherapy in thyroid neoplasms? |
| dc.creator.none.fl_str_mv |
Garcia Alvarez, Alejandro Hernando Cubero, Jorge Carmona Alonso, Ana Capdevila Castillon, Jaume |
| author |
Garcia Alvarez, Alejandro |
| author_facet |
Garcia Alvarez, Alejandro Hernando Cubero, Jorge Carmona Alonso, Ana Capdevila Castillon, Jaume |
| author_role |
author |
| author2 |
Hernando Cubero, Jorge Carmona Alonso, Ana Capdevila Castillon, Jaume |
| author2_role |
author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Garcia-Alvarez A, Hernando J, Carmona-Alonso A, Capdevila J] Unitat de Tumors Gastrointestinals i Endocrins, Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Tiroide - Càncer - Tractament Immunoteràpia ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy DISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Thyroid Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias de la tiroides Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia |
| topic |
Tiroide - Càncer - Tractament Immunoteràpia ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy DISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Thyroid Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias de la tiroides Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia |
| description |
Immunotherapy; Thyroid neoplasms; Tumor mutational burden |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/8342 |
| url |
https://hdl.handle.net/11351/8342 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Frontiers in Endocrinology;13 https://doi.org/10.3389/fendo.2022.929091 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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Frontiers Media |
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Frontiers Media |
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Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
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Departament de Salut de la Generalitat de Catalunya (DS) |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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