Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review

Babb de Villiers, Chantal; Plans Beriso, Elena; Erady, Chaitanya; Blackburn, Laura; Wilson, Hayley; Turner, Heather; Kuhn, Isla; Barahona López, Cristina; Diez Echave, Paul; Romulo Hernández, Orlando; Fernández de Larrea Baz, Nerea; Petrova, Dafina; Cierco Jimenez, Ramon; Fernández Navarro, Pablo; García Esquinas, Esther; Rodríguez Artalejo, Fernando; Sánchez, María José; Moreno Aguado, Víctor; Pollán, Marina; Pérez Gómez, Beatriz; Kroese, Mark

Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality globally. Early detection and personalised prevention strategies are crucial for reducing the burden of CVD. The use of biomarkers plays a pivotal role in identifying individuals at risk and facilitating timely intervent...

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Autores:	Babb de Villiers, Chantal, Plans Beriso, Elena, Erady, Chaitanya, Blackburn, Laura, Wilson, Hayley, Turner, Heather, Kuhn, Isla, Barahona López, Cristina, Diez Echave, Paul, Romulo Hernández, Orlando, Fernández de Larrea Baz, Nerea, Petrova, Dafina, Cierco Jimenez, Ramon, Fernández Navarro, Pablo, García Esquinas, Esther, Rodríguez Artalejo, Fernando, Sánchez, María José, Moreno Aguado, Víctor, Pollán, Marina, Pérez Gómez, Beatriz, Kroese, Mark
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2025
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/224184
Acceso en línea:	https://hdl.handle.net/2445/224184
Access Level:	acceso abierto
Palabra clave:	Medicaments cardiovasculars Lipoproteïnes de baixa densitat Arterioesclerosi Cardiovascular agents Low density lipoproteins Arteriosclerosis

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spelling	Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping ReviewBabb de Villiers, ChantalPlans Beriso, ElenaErady, ChaitanyaBlackburn, LauraWilson, HayleyTurner, HeatherKuhn, IslaBarahona López, CristinaDiez Echave, PaulRomulo Hernández, OrlandoFernández de Larrea Baz, NereaPetrova, DafinaCierco Jimenez, RamonFernández Navarro, PabloGarcía Esquinas, EstherRodríguez Artalejo, FernandoSánchez, María JoséMoreno Aguado, VíctorPollán, MarinaPérez Gómez, BeatrizKroese, MarkMedicaments cardiovascularsLipoproteïnes de baixa densitatArterioesclerosiCardiovascular agentsLow density lipoproteinsArteriosclerosisCardiovascular diseases (CVDs) are the leading cause of morbidity and mortality globally. Early detection and personalised prevention strategies are crucial for reducing the burden of CVD. The use of biomarkers plays a pivotal role in identifying individuals at risk and facilitating timely interventions. This rapid scoping review aims to identify and evaluate current research on biomarkers used for primary and secondary personalised prevention of CVD, highlighting evidence gaps and the integration of digital technologies. A comprehensive search was conducted in Medline and Embase databases from January 2020 to February 2023. Joanna Briggs Institute (JBI) Manual for Evidence Synthesis and PRISMA-ScR guidelines were followed. A total of 775 studies were included, with ischemic heart disease (IHD) and stroke being the most investigated CVDs. Molecular, cellular, imaging, physiological, and anthropometric biomarkers were included. Molecular biomarkers, particularly genetic and biochemical, were the most researched. For secondary prevention, there was considerable research using imaging biomarkers. Genetic biomarker research was the most frequent category of biomarker identified, particularly using variant analysis and polygenic scores, followed by biochemical, imaging, and physiological biomarkers. There was also evidence of the integration of artificial intelligence to enhance the predictive capabilities of these biomarkers. Despite progress, research gaps were identified for less common CVDs, such as aortic aneurysm and nonrheumatic valvular heart disease, and limited research investigating other molecular biomarker types, such as epigenetics and transcriptomics.MDPI2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion20 p.application/pdfhttps://hdl.handle.net/2445/224184Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/ijms26199346International Journal of Molecular Sciences, 2025, vol. 26, num. 19, 9346https://doi.org/10.3390/ijms26199346cc-by (c) Babb de Villiers, Chantal et al., 2025https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2241842026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review
title	Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review
spellingShingle	Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review Babb de Villiers, Chantal Medicaments cardiovasculars Lipoproteïnes de baixa densitat Arterioesclerosi Cardiovascular agents Low density lipoproteins Arteriosclerosis
title_short	Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review
title_full	Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review
title_fullStr	Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review
title_full_unstemmed	Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review
title_sort	Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review
dc.creator.none.fl_str_mv	Babb de Villiers, Chantal Plans Beriso, Elena Erady, Chaitanya Blackburn, Laura Wilson, Hayley Turner, Heather Kuhn, Isla Barahona López, Cristina Diez Echave, Paul Romulo Hernández, Orlando Fernández de Larrea Baz, Nerea Petrova, Dafina Cierco Jimenez, Ramon Fernández Navarro, Pablo García Esquinas, Esther Rodríguez Artalejo, Fernando Sánchez, María José Moreno Aguado, Víctor Pollán, Marina Pérez Gómez, Beatriz Kroese, Mark
author	Babb de Villiers, Chantal
author_facet	Babb de Villiers, Chantal Plans Beriso, Elena Erady, Chaitanya Blackburn, Laura Wilson, Hayley Turner, Heather Kuhn, Isla Barahona López, Cristina Diez Echave, Paul Romulo Hernández, Orlando Fernández de Larrea Baz, Nerea Petrova, Dafina Cierco Jimenez, Ramon Fernández Navarro, Pablo García Esquinas, Esther Rodríguez Artalejo, Fernando Sánchez, María José Moreno Aguado, Víctor Pollán, Marina Pérez Gómez, Beatriz Kroese, Mark
author_role	author
author2	Plans Beriso, Elena Erady, Chaitanya Blackburn, Laura Wilson, Hayley Turner, Heather Kuhn, Isla Barahona López, Cristina Diez Echave, Paul Romulo Hernández, Orlando Fernández de Larrea Baz, Nerea Petrova, Dafina Cierco Jimenez, Ramon Fernández Navarro, Pablo García Esquinas, Esther Rodríguez Artalejo, Fernando Sánchez, María José Moreno Aguado, Víctor Pollán, Marina Pérez Gómez, Beatriz Kroese, Mark
author2_role	author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Medicaments cardiovasculars Lipoproteïnes de baixa densitat Arterioesclerosi Cardiovascular agents Low density lipoproteins Arteriosclerosis
topic	Medicaments cardiovasculars Lipoproteïnes de baixa densitat Arterioesclerosi Cardiovascular agents Low density lipoproteins Arteriosclerosis
description	Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality globally. Early detection and personalised prevention strategies are crucial for reducing the burden of CVD. The use of biomarkers plays a pivotal role in identifying individuals at risk and facilitating timely interventions. This rapid scoping review aims to identify and evaluate current research on biomarkers used for primary and secondary personalised prevention of CVD, highlighting evidence gaps and the integration of digital technologies. A comprehensive search was conducted in Medline and Embase databases from January 2020 to February 2023. Joanna Briggs Institute (JBI) Manual for Evidence Synthesis and PRISMA-ScR guidelines were followed. A total of 775 studies were included, with ischemic heart disease (IHD) and stroke being the most investigated CVDs. Molecular, cellular, imaging, physiological, and anthropometric biomarkers were included. Molecular biomarkers, particularly genetic and biochemical, were the most researched. For secondary prevention, there was considerable research using imaging biomarkers. Genetic biomarker research was the most frequent category of biomarker identified, particularly using variant analysis and polygenic scores, followed by biochemical, imaging, and physiological biomarkers. There was also evidence of the integration of artificial intelligence to enhance the predictive capabilities of these biomarkers. Despite progress, research gaps were identified for less common CVDs, such as aortic aneurysm and nonrheumatic valvular heart disease, and limited research investigating other molecular biomarker types, such as epigenetics and transcriptomics.
publishDate	2025
dc.date.none.fl_str_mv	2025 2025 2025 2025
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/224184
url	https://hdl.handle.net/2445/224184
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.3390/ijms26199346 International Journal of Molecular Sciences, 2025, vol. 26, num. 19, 9346 https://doi.org/10.3390/ijms26199346
dc.rights.none.fl_str_mv	cc-by (c) Babb de Villiers, Chantal et al., 2025 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by (c) Babb de Villiers, Chantal et al., 2025 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	20 p. application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review

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