Oleoyl-Estrone

Oleoyl-estrone (OE) is a powerful slimming agent that is also present in plasma and adipose tissue, where it is synthesized. It acts through the formation of a derivative W. OE effects (and W levels) are proportional to the dose. OE reduces food intake but maintains energy expenditure (thermogenesis...

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Detalles Bibliográficos
Autores: Remesar Betlloch, Xavier, Fernández López, José Antonio, Alemany, Marià, 1946-
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2012
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/130029
Acceso en línea:https://hdl.handle.net/2445/130029
Access Level:acceso abierto
Palabra clave:Teixit adipós
Oleat d'estrona
Adipose tissues
Oleoyl-estrone
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spelling Oleoyl-EstroneRemesar Betlloch, XavierFernández López, José AntonioAlemany, Marià, 1946-Teixit adipósOleat d'estronaAdipose tissuesOleoyl-estroneOleoyl-estrone (OE) is a powerful slimming agent that is also present in plasma and adipose tissue, where it is synthesized. It acts through the formation of a derivative W. OE effects (and W levels) are proportional to the dose. OE reduces food intake but maintains energy expenditure (thermogenesis). The energy gap is fulfilled with adipose tissue fat, sparing body protein and maintaining glycemia (and glycogen) with lower insulin and leptin levels. OE (in fact W) acts through specific receptors, different from those of estrogen. OE increases cholesterol catabolism, reducing hypercholesterolemia in obese rats. The main metabolic effect on adipose tissue is a lowering of lipid synthesis, maintaining unchanged the intracellular lipolytic processes; the imbalance favors the progressive loss of fat, which is largely used by the muscle. OE administration induces additive effects with other antiobesity agents, such as β3-adrenergic agonists, forcing a massive loss of lipid. Corticosteroids, markedly limit OE action by altering the liver control of lipogenesis. OE also inhibits the action of 17β-hydroxysteroid dehydrogenase, decreasing the synthesis of β-estradiol and testosterone. Discontinuous treatment allows for maximal efficacy both in rats and humans. OE has the advantage that the loss of fat is maintained and does not require additional dietary limitations.Wiley2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/130029Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1002/med.20240Medicinal Research Reviews, 2012, vol. 32, num. 6, p. 1263-1291https://doi.org/10.1002/med.20240(c) Wiley, 2012info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1300292026-05-27T06:46:51Z
dc.title.none.fl_str_mv Oleoyl-Estrone
title Oleoyl-Estrone
spellingShingle Oleoyl-Estrone
Remesar Betlloch, Xavier
Teixit adipós
Oleat d'estrona
Adipose tissues
Oleoyl-estrone
title_short Oleoyl-Estrone
title_full Oleoyl-Estrone
title_fullStr Oleoyl-Estrone
title_full_unstemmed Oleoyl-Estrone
title_sort Oleoyl-Estrone
dc.creator.none.fl_str_mv Remesar Betlloch, Xavier
Fernández López, José Antonio
Alemany, Marià, 1946-
author Remesar Betlloch, Xavier
author_facet Remesar Betlloch, Xavier
Fernández López, José Antonio
Alemany, Marià, 1946-
author_role author
author2 Fernández López, José Antonio
Alemany, Marià, 1946-
author2_role author
author
dc.subject.none.fl_str_mv Teixit adipós
Oleat d'estrona
Adipose tissues
Oleoyl-estrone
topic Teixit adipós
Oleat d'estrona
Adipose tissues
Oleoyl-estrone
description Oleoyl-estrone (OE) is a powerful slimming agent that is also present in plasma and adipose tissue, where it is synthesized. It acts through the formation of a derivative W. OE effects (and W levels) are proportional to the dose. OE reduces food intake but maintains energy expenditure (thermogenesis). The energy gap is fulfilled with adipose tissue fat, sparing body protein and maintaining glycemia (and glycogen) with lower insulin and leptin levels. OE (in fact W) acts through specific receptors, different from those of estrogen. OE increases cholesterol catabolism, reducing hypercholesterolemia in obese rats. The main metabolic effect on adipose tissue is a lowering of lipid synthesis, maintaining unchanged the intracellular lipolytic processes; the imbalance favors the progressive loss of fat, which is largely used by the muscle. OE administration induces additive effects with other antiobesity agents, such as β3-adrenergic agonists, forcing a massive loss of lipid. Corticosteroids, markedly limit OE action by altering the liver control of lipogenesis. OE also inhibits the action of 17β-hydroxysteroid dehydrogenase, decreasing the synthesis of β-estradiol and testosterone. Discontinuous treatment allows for maximal efficacy both in rats and humans. OE has the advantage that the loss of fat is maintained and does not require additional dietary limitations.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/130029
url https://hdl.handle.net/2445/130029
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1002/med.20240
Medicinal Research Reviews, 2012, vol. 32, num. 6, p. 1263-1291
https://doi.org/10.1002/med.20240
dc.rights.none.fl_str_mv (c) Wiley, 2012
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Wiley, 2012
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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