Replication data for: Surpassing the constraint of stereospecificity in artificial inclusion bodies fabricated through Zn-His coordination

This work features the development of artificial protein micro-granules for clinical applications, inspired by naturally occurring amyloid structures in bacterial inclusion bodies and mammalian endocrine granules. The authors developed these synthetic granules using a reversible coordination method...

Descripción completa

Detalles Bibliográficos
Autores: Sanchez, Julieta M., Parladé, Eloi, Voltà-Durán, Eric, Mangues, Ramon, Villaverde, Antonio, Vazquez, Esther, Unzueta, Ugutz
Tipo de recurso: conjunto de datos
Fecha de publicación:2024
País:España
Institución:Consorci de Serveis Universitaris de Catalunya (CSUC)
Repositorio:CORA.Repositori de Dades de Recerca
OAI Identifier:oai:dnet:cora.rdr____::14485ff0338e308eca78066352b2515f
Acceso en línea:https://doi.org/10.34810/DATA1773
Access Level:acceso abierto
Palabra clave:Engineering
Medicine, Health and Life Sciences
Recombinant protein
Microparticles
Amyloids
Biomimetics
Protein materials
Stereospecificity
id ES_2fd3d3d7fa32197fa83b2694eaeea421
oai_identifier_str oai:dnet:cora.rdr____::14485ff0338e308eca78066352b2515f
network_acronym_str ES
network_name_str España
repository_id_str
spelling Replication data for: Surpassing the constraint of stereospecificity in artificial inclusion bodies fabricated through Zn-His coordinationSanchez, Julieta M.Parladé, EloiVoltà-Durán, EricMangues, RamonVillaverde, AntonioVazquez, EstherUnzueta, UgutzEngineeringMedicine, Health and Life SciencesRecombinant proteinMicroparticlesAmyloidsBiomimeticsProtein materialsStereospecificityThis work features the development of artificial protein micro-granules for clinical applications, inspired by naturally occurring amyloid structures in bacterial inclusion bodies and mammalian endocrine granules. The authors developed these synthetic granules using a reversible coordination method involving histidine residues and zinc ions (Zn+2). Unlike natural systems, which rely on stereospecificity, the authors demonstrated that their approach allows the formation of hybrid protein materials using two distinct polypeptides, without requiring structural similarities. This method enables the creation of combined protein depots, offering new possibilities for delivering therapeutic proteins in defined ratios and potentially enhancing functional synergies for medical applications.CORA.Repositori de Dades de RecercaParladé Molist, Eloi2024info:eu-repo/semantics/datasethttps://doi.org/10.34810/DATA1773reponame:CORA.Repositori de Dades de Recercainstname:Consorci de Serveis Universitaris de Catalunya (CSUC)Inglésinfo:eu-repo/semantics/openAccessCC0 1.0oai:dnet:cora.rdr____::14485ff0338e308eca78066352b2515f2026-06-17T12:20:17Z
dc.title.none.fl_str_mv Replication data for: Surpassing the constraint of stereospecificity in artificial inclusion bodies fabricated through Zn-His coordination
title Replication data for: Surpassing the constraint of stereospecificity in artificial inclusion bodies fabricated through Zn-His coordination
spellingShingle Replication data for: Surpassing the constraint of stereospecificity in artificial inclusion bodies fabricated through Zn-His coordination
Sanchez, Julieta M.
Engineering
Medicine, Health and Life Sciences
Recombinant protein
Microparticles
Amyloids
Biomimetics
Protein materials
Stereospecificity
title_short Replication data for: Surpassing the constraint of stereospecificity in artificial inclusion bodies fabricated through Zn-His coordination
title_full Replication data for: Surpassing the constraint of stereospecificity in artificial inclusion bodies fabricated through Zn-His coordination
title_fullStr Replication data for: Surpassing the constraint of stereospecificity in artificial inclusion bodies fabricated through Zn-His coordination
title_full_unstemmed Replication data for: Surpassing the constraint of stereospecificity in artificial inclusion bodies fabricated through Zn-His coordination
title_sort Replication data for: Surpassing the constraint of stereospecificity in artificial inclusion bodies fabricated through Zn-His coordination
dc.creator.none.fl_str_mv Sanchez, Julieta M.
Parladé, Eloi
Voltà-Durán, Eric
Mangues, Ramon
Villaverde, Antonio
Vazquez, Esther
Unzueta, Ugutz
author Sanchez, Julieta M.
author_facet Sanchez, Julieta M.
Parladé, Eloi
Voltà-Durán, Eric
Mangues, Ramon
Villaverde, Antonio
Vazquez, Esther
Unzueta, Ugutz
author_role author
author2 Parladé, Eloi
Voltà-Durán, Eric
Mangues, Ramon
Villaverde, Antonio
Vazquez, Esther
Unzueta, Ugutz
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Parladé Molist, Eloi
dc.subject.none.fl_str_mv Engineering
Medicine, Health and Life Sciences
Recombinant protein
Microparticles
Amyloids
Biomimetics
Protein materials
Stereospecificity
topic Engineering
Medicine, Health and Life Sciences
Recombinant protein
Microparticles
Amyloids
Biomimetics
Protein materials
Stereospecificity
description This work features the development of artificial protein micro-granules for clinical applications, inspired by naturally occurring amyloid structures in bacterial inclusion bodies and mammalian endocrine granules. The authors developed these synthetic granules using a reversible coordination method involving histidine residues and zinc ions (Zn+2). Unlike natural systems, which rely on stereospecificity, the authors demonstrated that their approach allows the formation of hybrid protein materials using two distinct polypeptides, without requiring structural similarities. This method enables the creation of combined protein depots, offering new possibilities for delivering therapeutic proteins in defined ratios and potentially enhancing functional synergies for medical applications.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
format dataset
dc.identifier.none.fl_str_mv https://doi.org/10.34810/DATA1773
url https://doi.org/10.34810/DATA1773
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
CC0 1.0
eu_rights_str_mv openAccess
rights_invalid_str_mv CC0 1.0
dc.publisher.none.fl_str_mv CORA.Repositori de Dades de Recerca
publisher.none.fl_str_mv CORA.Repositori de Dades de Recerca
dc.source.none.fl_str_mv reponame:CORA.Repositori de Dades de Recerca
instname:Consorci de Serveis Universitaris de Catalunya (CSUC)
instname_str Consorci de Serveis Universitaris de Catalunya (CSUC)
reponame_str CORA.Repositori de Dades de Recerca
collection CORA.Repositori de Dades de Recerca
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405503924207616
score 15.81155

Similares en LA Referencia