Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells

The anticarcinogenic activity of synthetic 1-O-octadecyl-2,3- dibutyroilglycerol (D-SCAKG) in tumor-cell line of colonocytes (SW620) was performed. The effect of the previously digested D-SCAKG under in vitro intestinal conditions was compared to the bioactivity of non-digested D-SCAKG. Antiprolifer...

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Detalles Bibliográficos
Autores: Molina, Susana, Morán-Valero, María I., Martín, Diana, Vázquez, Luis, Vargas, Teodoro, Torres, Carlos F., Ramírez de Molina, Ana, Reglero, Guillermo
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2013
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/99768
Acceso en línea:http://hdl.handle.net/10261/99768
Access Level:acceso abierto
Palabra clave:Alkylglycerols
Butyric acid
Lipid digestion
Lipid-delivery pro-drugs
Antiproliferative compounds
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spelling Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cellsMolina, SusanaMorán-Valero, María I.Martín, DianaVázquez, LuisVargas, TeodoroTorres, Carlos F.Ramírez de Molina, AnaReglero, GuillermoAlkylglycerolsButyric acidLipid digestionLipid-delivery pro-drugsAntiproliferative compoundsThe anticarcinogenic activity of synthetic 1-O-octadecyl-2,3- dibutyroilglycerol (D-SCAKG) in tumor-cell line of colonocytes (SW620) was performed. The effect of the previously digested D-SCAKG under in vitro intestinal conditions was compared to the bioactivity of non-digested D-SCAKG. Antiproliferative activity of each individual product from digestion (1-O-octadecyl-2-butyroilglycerol; 1-O-octadecyl glycerol; butyric acid) was also performed. The impact of solubilization of lipid products within micellar structures was also tested. The 1-O-octadecyl glycerol was the most active compound, followed by 1-O-octadecyl-2-butyroilglycerol, D-SCAKG and butyric acid. The 1-O-octadecyl glycerol and butyric acid were the only molecules that showed antiproliferative effect in absence of micelles. Digested D-SCAKG was 4-fold more effective than non-digested D-SCAKG. A synergism between 1-O-octadecyl-2-butyroilglycerol and 1-O-octadecyl glycerol was evidenced. As summary, the synthetic D-SCAKG seems to be an interesting antitumoral lipid against colonocytes, especially after previous intestinal digestion, and mainly due to the synergism of the major products, namely 1-O-octadecyl-2- butyroilglycerol and 1-O-octadecyl glycerol. At the same time, 1-O-octadecyl-2-butyroilglycerol would constitute a stable esterified form of butyric acid for its vehiculization. © 2013 Published by Elsevier Ireland Ltd.This work was supported by Spanish Ministry of Science and Innovation (Plan Nacional I+D+i AGL2010-21565, RyC 2008-03734), Comunidad de Madrid (ALIBIRD, S2009/AGR-1469), European Union Structural Funds and Consolider-Ingenio 2010 Ref. CSD/2007/00063 (FUN-C-FOOD).Peer ReviewedElsevierComunidad de MadridMinisterio de Ciencia e Innovación (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2014201420132014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/99768reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#S2009/AGR-1469/ALIBIRDhttp://dx.doi.org/10.1016/j.chemphyslip.2013.07.011Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/997682026-05-22T06:33:51Z
dc.title.none.fl_str_mv Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells
title Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells
spellingShingle Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells
Molina, Susana
Alkylglycerols
Butyric acid
Lipid digestion
Lipid-delivery pro-drugs
Antiproliferative compounds
title_short Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells
title_full Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells
title_fullStr Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells
title_full_unstemmed Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells
title_sort Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells
dc.creator.none.fl_str_mv Molina, Susana
Morán-Valero, María I.
Martín, Diana
Vázquez, Luis
Vargas, Teodoro
Torres, Carlos F.
Ramírez de Molina, Ana
Reglero, Guillermo
author Molina, Susana
author_facet Molina, Susana
Morán-Valero, María I.
Martín, Diana
Vázquez, Luis
Vargas, Teodoro
Torres, Carlos F.
Ramírez de Molina, Ana
Reglero, Guillermo
author_role author
author2 Morán-Valero, María I.
Martín, Diana
Vázquez, Luis
Vargas, Teodoro
Torres, Carlos F.
Ramírez de Molina, Ana
Reglero, Guillermo
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Comunidad de Madrid
Ministerio de Ciencia e Innovación (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Alkylglycerols
Butyric acid
Lipid digestion
Lipid-delivery pro-drugs
Antiproliferative compounds
topic Alkylglycerols
Butyric acid
Lipid digestion
Lipid-delivery pro-drugs
Antiproliferative compounds
description The anticarcinogenic activity of synthetic 1-O-octadecyl-2,3- dibutyroilglycerol (D-SCAKG) in tumor-cell line of colonocytes (SW620) was performed. The effect of the previously digested D-SCAKG under in vitro intestinal conditions was compared to the bioactivity of non-digested D-SCAKG. Antiproliferative activity of each individual product from digestion (1-O-octadecyl-2-butyroilglycerol; 1-O-octadecyl glycerol; butyric acid) was also performed. The impact of solubilization of lipid products within micellar structures was also tested. The 1-O-octadecyl glycerol was the most active compound, followed by 1-O-octadecyl-2-butyroilglycerol, D-SCAKG and butyric acid. The 1-O-octadecyl glycerol and butyric acid were the only molecules that showed antiproliferative effect in absence of micelles. Digested D-SCAKG was 4-fold more effective than non-digested D-SCAKG. A synergism between 1-O-octadecyl-2-butyroilglycerol and 1-O-octadecyl glycerol was evidenced. As summary, the synthetic D-SCAKG seems to be an interesting antitumoral lipid against colonocytes, especially after previous intestinal digestion, and mainly due to the synergism of the major products, namely 1-O-octadecyl-2- butyroilglycerol and 1-O-octadecyl glycerol. At the same time, 1-O-octadecyl-2-butyroilglycerol would constitute a stable esterified form of butyric acid for its vehiculization. © 2013 Published by Elsevier Ireland Ltd.
publishDate 2013
dc.date.none.fl_str_mv 2013
2014
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/99768
url http://hdl.handle.net/10261/99768
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
S2009/AGR-1469/ALIBIRD
http://dx.doi.org/10.1016/j.chemphyslip.2013.07.011
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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