Quantifying the patients perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire

BACKGROUND: The assessment of self-reported outcomes in neuromyelitis optica spectrum disorder (NMOSD) is limited by the lack of validated disease-specific measures. The SymptoMScreen (SyMS) is a patient-reported questionnaire for measuring symptom severity in different domains affected by multiple...

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Autores: Meca Lallana, José E., Maurino, Jorge, Pérez Miralles, Francisco, Forero, Lucía, Sepúlveda, María, Calles, Carmen, Martínez Ginés, María L., González Suárez, Inés, Boyero, Sabas, Romero Pinel, Lucía, Sempere, Ángel P., Meca Lallana, Virginia, Querol, Luis, Costa Frossard, Lucienne, Prefasi, Daniel, Gómez Ballesteros, Rocío, Ballesteros Rodríguez, Francisco Javier
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/52785
Acceso en línea:http://hdl.handle.net/10810/52785
Access Level:acceso abierto
Palabra clave:neuromyelitis optica
SymptoMScreen (SyMS)
multiple sclerosis (MS)
Mokken's criteria
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spelling Quantifying the patients perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaireMeca Lallana, José E.Maurino, JorgePérez Miralles, FranciscoForero, LucíaSepúlveda, MaríaCalles, CarmenMartínez Ginés, María L.González Suárez, InésBoyero, SabasRomero Pinel, LucíaSempere, Ángel P.Meca Lallana, VirginiaQuerol, LuisCosta Frossard, LuciennePrefasi, DanielGómez Ballesteros, RocíoBallesteros Rodríguez, Francisco Javierneuromyelitis opticaSymptoMScreen (SyMS)multiple sclerosis (MS)Mokken's criteriaBACKGROUND: The assessment of self-reported outcomes in neuromyelitis optica spectrum disorder (NMOSD) is limited by the lack of validated disease-specific measures. The SymptoMScreen (SyMS) is a patient-reported questionnaire for measuring symptom severity in different domains affected by multiple sclerosis (MS), but has not been thoroughly evaluated in NMOSD. The aim of this study was to assess the psychometric properties of the SyMS in a sample of patients with NMOSD. METHODS: A non-interventional, cross-sectional study in adult subjects with NMOSD (Wingerchuk 2015 criteria) was conducted at 13 neuroimmunology clinics applying the SyMS. A non-parametric item response theory procedure, Mokken analysis, was performed to assess the underlying dimensional structure and scalability of items and overall questionnaire. All analyses were performed with R (v4.0.3) using the mokken library. RESULTS: A total of 70 patients were studied (mean age: 47.5 ± 15 years, 80% female, mean Expanded Disability Status Scale score: 3.0 [interquartile range 1.5, 4.5]). Symptom severity was low (median SyMS score: 19.0 [interquartile range 10.0, 32.0]). The SyMS showed a robust internal reliability (Cronbach's alpha: 0.90 [95% confidence interval 0.86, 0.93]) and behaved as a unidimensional scale with all items showing scalability coefficients > 0.30. The overall SyMS scalability was 0.45 conforming to a medium scale according to Mokken's criteria. Fatigue and body pain were the domains with the highest scalability coefficients. The SyMS was associated with disability (rho: 0.586), and physical and psychological quality of life (rho: 0.856 and 0.696, respectively). CONCLUSIONS: The SyMS shows appropriate psychometric characteristics and may constitute a valuable and easy-to-implement option to measure symptom severity in patients with NMOSD.This study was funded by the Medical Department of Roche Farma Spain (ML41397)Public Library Of Science202120212021info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/52785reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255317info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0)Atribución 3.0 Españaoai:addi.ehu.eus:10810/527852026-06-18T09:23:17Z
dc.title.none.fl_str_mv Quantifying the patients perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire
title Quantifying the patients perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire
spellingShingle Quantifying the patients perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire
Meca Lallana, José E.
neuromyelitis optica
SymptoMScreen (SyMS)
multiple sclerosis (MS)
Mokken's criteria
title_short Quantifying the patients perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire
title_full Quantifying the patients perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire
title_fullStr Quantifying the patients perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire
title_full_unstemmed Quantifying the patients perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire
title_sort Quantifying the patients perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire
dc.creator.none.fl_str_mv Meca Lallana, José E.
Maurino, Jorge
Pérez Miralles, Francisco
Forero, Lucía
Sepúlveda, María
Calles, Carmen
Martínez Ginés, María L.
González Suárez, Inés
Boyero, Sabas
Romero Pinel, Lucía
Sempere, Ángel P.
Meca Lallana, Virginia
Querol, Luis
Costa Frossard, Lucienne
Prefasi, Daniel
Gómez Ballesteros, Rocío
Ballesteros Rodríguez, Francisco Javier
author Meca Lallana, José E.
author_facet Meca Lallana, José E.
Maurino, Jorge
Pérez Miralles, Francisco
Forero, Lucía
Sepúlveda, María
Calles, Carmen
Martínez Ginés, María L.
González Suárez, Inés
Boyero, Sabas
Romero Pinel, Lucía
Sempere, Ángel P.
Meca Lallana, Virginia
Querol, Luis
Costa Frossard, Lucienne
Prefasi, Daniel
Gómez Ballesteros, Rocío
Ballesteros Rodríguez, Francisco Javier
author_role author
author2 Maurino, Jorge
Pérez Miralles, Francisco
Forero, Lucía
Sepúlveda, María
Calles, Carmen
Martínez Ginés, María L.
González Suárez, Inés
Boyero, Sabas
Romero Pinel, Lucía
Sempere, Ángel P.
Meca Lallana, Virginia
Querol, Luis
Costa Frossard, Lucienne
Prefasi, Daniel
Gómez Ballesteros, Rocío
Ballesteros Rodríguez, Francisco Javier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv neuromyelitis optica
SymptoMScreen (SyMS)
multiple sclerosis (MS)
Mokken's criteria
topic neuromyelitis optica
SymptoMScreen (SyMS)
multiple sclerosis (MS)
Mokken's criteria
description BACKGROUND: The assessment of self-reported outcomes in neuromyelitis optica spectrum disorder (NMOSD) is limited by the lack of validated disease-specific measures. The SymptoMScreen (SyMS) is a patient-reported questionnaire for measuring symptom severity in different domains affected by multiple sclerosis (MS), but has not been thoroughly evaluated in NMOSD. The aim of this study was to assess the psychometric properties of the SyMS in a sample of patients with NMOSD. METHODS: A non-interventional, cross-sectional study in adult subjects with NMOSD (Wingerchuk 2015 criteria) was conducted at 13 neuroimmunology clinics applying the SyMS. A non-parametric item response theory procedure, Mokken analysis, was performed to assess the underlying dimensional structure and scalability of items and overall questionnaire. All analyses were performed with R (v4.0.3) using the mokken library. RESULTS: A total of 70 patients were studied (mean age: 47.5 ± 15 years, 80% female, mean Expanded Disability Status Scale score: 3.0 [interquartile range 1.5, 4.5]). Symptom severity was low (median SyMS score: 19.0 [interquartile range 10.0, 32.0]). The SyMS showed a robust internal reliability (Cronbach's alpha: 0.90 [95% confidence interval 0.86, 0.93]) and behaved as a unidimensional scale with all items showing scalability coefficients > 0.30. The overall SyMS scalability was 0.45 conforming to a medium scale according to Mokken's criteria. Fatigue and body pain were the domains with the highest scalability coefficients. The SyMS was associated with disability (rho: 0.586), and physical and psychological quality of life (rho: 0.856 and 0.696, respectively). CONCLUSIONS: The SyMS shows appropriate psychometric characteristics and may constitute a valuable and easy-to-implement option to measure symptom severity in patients with NMOSD.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/52785
url http://hdl.handle.net/10810/52785
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255317
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library Of Science
publisher.none.fl_str_mv Public Library Of Science
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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