Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population

Introduction: Urban environmental exposures might contribute to the incidence of Alzheimer's disease (AD). Our aim was to identify structural brain imaging correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk of AD. Methods: Two hundred twelve part...

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Autores: Falcón, Carles, Gascon, Mireia, Molinuevo, José Luis, Operto, Grégory, Cirach, Marta, Gotsens, Xavier, Fauria, Karine, Arenaza Urquijo, Eider M., Pujol, Jesús, Sunyer, Jordi, Nieuwenhuijsen, Mark J., Gispert, Juan Domingo, Crous Bou, Marta, The Alfa Study
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/179338
Acceso en línea:https://hdl.handle.net/2445/179338
Access Level:acceso abierto
Palabra clave:Malaltia d'Alzheimer
Contaminació
Factors de risc en les malalties
Alzheimer's disease
Pollution
Risk factors in diseases
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spelling Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's populationFalcón, CarlesGascon, MireiaMolinuevo, José LuisOperto, GrégoryCirach, MartaGotsens, XavierFauria, KarineArenaza Urquijo, Eider M.Pujol, JesúsSunyer, JordiNieuwenhuijsen, Mark J.Gispert, Juan DomingoCrous Bou, MartaThe Alfa StudyMalaltia d'AlzheimerContaminacióFactors de risc en les malaltiesAlzheimer's diseasePollutionRisk factors in diseasesIntroduction: Urban environmental exposures might contribute to the incidence of Alzheimer's disease (AD). Our aim was to identify structural brain imaging correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk of AD. Methods: Two hundred twelve participants with brain scans and residing in Barcelona, Spain, were included. Land use regression models were used to estimate residential exposure to air pollutants. The daily average noise level was obtained from noise maps. Residential green exposure indicators were also generated. A cerebral 3D-T1 was acquired to obtain information on brain morphology. Voxel-based morphometry statistical analyses were conducted to determine the areas of the brain in which regional gray matter (GM) and white matter (WM) volumes were associated with environmental exposures. Results: Exposure to nitrogen dioxide was associated with lower GM volume in the precuneus and greater WM volume in the splenium of the corpus callosum and inferior longitudinal fasciculus. In contrast, exposure to fine particulate matter was associated with greater GM in cerebellum and WM in the splenium of corpus callosum, the superior longitudinal fasciculus, and cingulum cingulate gyrus. Noise was positively associated with WM volume in the body of the corpus callosum. Exposure to greenness was associated with greater GM volume in the middle frontal, precentral, and the temporal pole. Discussion: In cognitively unimpaired adults with increased risk of AD, exposure to air pollution, noise, and green areas are associated with GM and WM volumes of specific brain areas known to be affected in AD, thus potentially conferring a higher vulnerability to the disease.Wiley2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/179338Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1002/dad2.12205Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021, vol. 13, num. 1, p. e12205https://doi.org/10.1002/dad2.12205cc by-nc-nd (c) Falcón, Carles et al., 2021http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1793382026-05-29T05:05:01Z
dc.title.none.fl_str_mv Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population
title Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population
spellingShingle Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population
Falcón, Carles
Malaltia d'Alzheimer
Contaminació
Factors de risc en les malalties
Alzheimer's disease
Pollution
Risk factors in diseases
title_short Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population
title_full Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population
title_fullStr Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population
title_full_unstemmed Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population
title_sort Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population
dc.creator.none.fl_str_mv Falcón, Carles
Gascon, Mireia
Molinuevo, José Luis
Operto, Grégory
Cirach, Marta
Gotsens, Xavier
Fauria, Karine
Arenaza Urquijo, Eider M.
Pujol, Jesús
Sunyer, Jordi
Nieuwenhuijsen, Mark J.
Gispert, Juan Domingo
Crous Bou, Marta
The Alfa Study
author Falcón, Carles
author_facet Falcón, Carles
Gascon, Mireia
Molinuevo, José Luis
Operto, Grégory
Cirach, Marta
Gotsens, Xavier
Fauria, Karine
Arenaza Urquijo, Eider M.
Pujol, Jesús
Sunyer, Jordi
Nieuwenhuijsen, Mark J.
Gispert, Juan Domingo
Crous Bou, Marta
The Alfa Study
author_role author
author2 Gascon, Mireia
Molinuevo, José Luis
Operto, Grégory
Cirach, Marta
Gotsens, Xavier
Fauria, Karine
Arenaza Urquijo, Eider M.
Pujol, Jesús
Sunyer, Jordi
Nieuwenhuijsen, Mark J.
Gispert, Juan Domingo
Crous Bou, Marta
The Alfa Study
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Contaminació
Factors de risc en les malalties
Alzheimer's disease
Pollution
Risk factors in diseases
topic Malaltia d'Alzheimer
Contaminació
Factors de risc en les malalties
Alzheimer's disease
Pollution
Risk factors in diseases
description Introduction: Urban environmental exposures might contribute to the incidence of Alzheimer's disease (AD). Our aim was to identify structural brain imaging correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk of AD. Methods: Two hundred twelve participants with brain scans and residing in Barcelona, Spain, were included. Land use regression models were used to estimate residential exposure to air pollutants. The daily average noise level was obtained from noise maps. Residential green exposure indicators were also generated. A cerebral 3D-T1 was acquired to obtain information on brain morphology. Voxel-based morphometry statistical analyses were conducted to determine the areas of the brain in which regional gray matter (GM) and white matter (WM) volumes were associated with environmental exposures. Results: Exposure to nitrogen dioxide was associated with lower GM volume in the precuneus and greater WM volume in the splenium of the corpus callosum and inferior longitudinal fasciculus. In contrast, exposure to fine particulate matter was associated with greater GM in cerebellum and WM in the splenium of corpus callosum, the superior longitudinal fasciculus, and cingulum cingulate gyrus. Noise was positively associated with WM volume in the body of the corpus callosum. Exposure to greenness was associated with greater GM volume in the middle frontal, precentral, and the temporal pole. Discussion: In cognitively unimpaired adults with increased risk of AD, exposure to air pollution, noise, and green areas are associated with GM and WM volumes of specific brain areas known to be affected in AD, thus potentially conferring a higher vulnerability to the disease.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/179338
url https://hdl.handle.net/2445/179338
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/dad2.12205
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021, vol. 13, num. 1, p. e12205
https://doi.org/10.1002/dad2.12205
dc.rights.none.fl_str_mv cc by-nc-nd (c) Falcón, Carles et al., 2021
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Falcón, Carles et al., 2021
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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