Comparative transcriptomics and gene discovery in caecilian amphibians

Many aspects of biological diversity and their life mechanisms remain unknown and understudied. With the advent of the genomic era, RNA sequencing (RNA-seq) has become one of the most powerful tools to unravel the secrets of biological adaptation and diversity in all species through their particular...

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Detalles Bibliográficos
Autor: Torres-Sánchez, María
Tipo de recurso: tesis doctoral
Fecha de publicación:2018
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/16518
Acceso en línea:https://hdl.handle.net/20.500.14352/16518
Access Level:acceso abierto
Palabra clave:636.082.11(043.2)
575(043.2)
Gene Expression
Caecilians
Amphibians
Expresión génica
Cecilias
Anfibios
Genética
2401.17 Invertebrados
2409 Genética
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oai_identifier_str oai:docta.ucm.es:20.500.14352/16518
network_acronym_str ES
network_name_str España
repository_id_str
spelling Comparative transcriptomics and gene discovery in caecilian amphibiansTranscriptómica comparada y descubrimiento de genes en ceciliasTorres-Sánchez, María636.082.11(043.2)575(043.2)Gene ExpressionCaeciliansAmphibiansExpresión génicaCeciliasAnfibiosAnfibiosGenética2401.17 Invertebrados2409 GenéticaMany aspects of biological diversity and their life mechanisms remain unknown and understudied. With the advent of the genomic era, RNA sequencing (RNA-seq) has become one of the most powerful tools to unravel the secrets of biological adaptation and diversity in all species through their particular gene expression profiles. Here, we studied comparatively the genes expressed in different tissues of several species of one of the least known group of vertebrates, the caecilians (order Gymnophiona). Caecilians are fossorial, limbless, tropical amphibians that constitute the sister group of frogs and salamanders. Little is known about this enigmatic animal group. To improve the understanding of caecilian ecology and evolution, we have analysed caecilian genomic functional elements at three levels: across other vertebrates, across caecilian species and among caecilian tissue types. Our study provides valuable insights about the expansion of gene machineries in vertebrates, points out proteincoding genes involved in the specific evolutionary adaptations of caecilian amphibians, and highlights important functional elements in the caecilian skin tissue type. To our knowledge, this is the first large-scale genomic characterization of the genetic functional elements of this secretive vertebrate group, and it provides the basis for future research on the molecular elements underlying the remarkable biology of caecilian amphibians.Universidad Complutense de MadridSan Mauro Martín, DiegoUniversidad Complutense de Madrid20182018-11-0520182018-11-05doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/16518reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/165182026-06-02T12:44:21Z
dc.title.none.fl_str_mv Comparative transcriptomics and gene discovery in caecilian amphibians
Transcriptómica comparada y descubrimiento de genes en cecilias
title Comparative transcriptomics and gene discovery in caecilian amphibians
spellingShingle Comparative transcriptomics and gene discovery in caecilian amphibians
Torres-Sánchez, María
636.082.11(043.2)
575(043.2)
Gene Expression
Caecilians
Amphibians
Expresión génica
Cecilias
Anfibios
Anfibios
Genética
2401.17 Invertebrados
2409 Genética
title_short Comparative transcriptomics and gene discovery in caecilian amphibians
title_full Comparative transcriptomics and gene discovery in caecilian amphibians
title_fullStr Comparative transcriptomics and gene discovery in caecilian amphibians
title_full_unstemmed Comparative transcriptomics and gene discovery in caecilian amphibians
title_sort Comparative transcriptomics and gene discovery in caecilian amphibians
dc.creator.none.fl_str_mv Torres-Sánchez, María
author Torres-Sánchez, María
author_facet Torres-Sánchez, María
author_role author
dc.contributor.none.fl_str_mv San Mauro Martín, Diego
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 636.082.11(043.2)
575(043.2)
Gene Expression
Caecilians
Amphibians
Expresión génica
Cecilias
Anfibios
Anfibios
Genética
2401.17 Invertebrados
2409 Genética
topic 636.082.11(043.2)
575(043.2)
Gene Expression
Caecilians
Amphibians
Expresión génica
Cecilias
Anfibios
Anfibios
Genética
2401.17 Invertebrados
2409 Genética
description Many aspects of biological diversity and their life mechanisms remain unknown and understudied. With the advent of the genomic era, RNA sequencing (RNA-seq) has become one of the most powerful tools to unravel the secrets of biological adaptation and diversity in all species through their particular gene expression profiles. Here, we studied comparatively the genes expressed in different tissues of several species of one of the least known group of vertebrates, the caecilians (order Gymnophiona). Caecilians are fossorial, limbless, tropical amphibians that constitute the sister group of frogs and salamanders. Little is known about this enigmatic animal group. To improve the understanding of caecilian ecology and evolution, we have analysed caecilian genomic functional elements at three levels: across other vertebrates, across caecilian species and among caecilian tissue types. Our study provides valuable insights about the expansion of gene machineries in vertebrates, points out proteincoding genes involved in the specific evolutionary adaptations of caecilian amphibians, and highlights important functional elements in the caecilian skin tissue type. To our knowledge, this is the first large-scale genomic characterization of the genetic functional elements of this secretive vertebrate group, and it provides the basis for future research on the molecular elements underlying the remarkable biology of caecilian amphibians.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-11-05
2018
2018-11-05
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/16518
url https://hdl.handle.net/20.500.14352/16518
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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