Exploring Urban Green Spaces' Effect against Traffic Exposure on Childhood Leukaemia Incidence

Background: Several environmental factors seem to be involved in childhood leukaemia incidence. Traffic exposure could increase the risk while urban green spaces (UGS) exposure could reduce it. However, there is no evidence how these two factors interact on this infant pathology. Objectives: to eval...

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Autores: Ojeda Sánchez, Carlos, García-Pérez, Javier, Gomez-Barroso, Diana, Domínguez-Castillo, Alejandro, Pardo Romaguera, Elena, Cañete, Adela, Ortega-García, Juan Antonio, Ramis, Rebeca
Tipo de documento: artigo
Data de publicação:2023
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositório:Repisalud
Idioma:inglês
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/16788
Acesso em linha:http://hdl.handle.net/20.500.12105/16788
Access Level:Acceso aberto
Palavra-chave:Parks, Recreational
Leukemia, Myeloid, Acute
Child
Infant
Female
Humans
Incidence
Case-Control Studies
Housing
Environmental Exposure
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spelling Exploring Urban Green Spaces' Effect against Traffic Exposure on Childhood Leukaemia IncidenceOjeda Sánchez, CarlosGarcía-Pérez, JavierGomez-Barroso, DianaDomínguez-Castillo, AlejandroPardo Romaguera, ElenaCañete, AdelaOrtega-García, Juan AntonioRamis, RebecaParks, RecreationalLeukemia, Myeloid, AcuteChildInfantFemaleHumansIncidenceCase-Control StudiesHousingEnvironmental ExposureBackground: Several environmental factors seem to be involved in childhood leukaemia incidence. Traffic exposure could increase the risk while urban green spaces (UGS) exposure could reduce it. However, there is no evidence how these two factors interact on this infant pathology. Objectives: to evaluate how residential proximity to UGS could be an environmental protective factor against traffic exposure on childhood leukaemia incidence. Methods: A population-based case control study was conducted across thirty Spanish regions during the period 2000-2018. It included 2526 incident cases and 15,156, individually matched by sex, year-of-birth, and place-of-residence. Using the geographical coordinates of the participants' home residences, a 500 m proxy for exposure to UGS was built. Annual average daily traffic (AADT) was estimated for all types of roads 100 m near the children's residence. Odds ratios (ORs) and 95% confidence intervals (95% CIs), UGS, traffic exposure, and their possible interactions were calculated for overall childhood leukaemia, and the acute lymphoblastic (ALL) and acute myeloblastic leukaemia (AML) subtypes, with adjustment for socio-demographic covariates. Results: We found an increment of childhood leukaemia incidence related to traffic exposure, for every 100 AADT increase the incidence raised 1.1% (95% CI: 0.58-1.61%). UGS exposure showed an incidence reduction for the highest exposure level, Q5 (OR = 0.63; 95% CI = 0.54-0.72). Regression models with both traffic exposure and UGS exposure variables showed similar results but the interaction was not significant. Conclusions: Despite their opposite effects on childhood leukaemia incidence individually, our results do not suggest a possible interaction between both exposures. This is the first study about the interaction of these two environmental factors; consequently, it is necessary to continue taking into account more individualized data and other possible environmental risk factors involved.Multidisciplinary Digital Publishing Institute (MDPI)Instituto de Salud Carlos III20232023-12-1320232023-01-3120232023-01-31research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/16788reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/167882026-06-12T12:43:37Z
dc.title.none.fl_str_mv Exploring Urban Green Spaces' Effect against Traffic Exposure on Childhood Leukaemia Incidence
title Exploring Urban Green Spaces' Effect against Traffic Exposure on Childhood Leukaemia Incidence
spellingShingle Exploring Urban Green Spaces' Effect against Traffic Exposure on Childhood Leukaemia Incidence
Ojeda Sánchez, Carlos
Parks, Recreational
Leukemia, Myeloid, Acute
Child
Infant
Female
Humans
Incidence
Case-Control Studies
Housing
Environmental Exposure
title_short Exploring Urban Green Spaces' Effect against Traffic Exposure on Childhood Leukaemia Incidence
title_full Exploring Urban Green Spaces' Effect against Traffic Exposure on Childhood Leukaemia Incidence
title_fullStr Exploring Urban Green Spaces' Effect against Traffic Exposure on Childhood Leukaemia Incidence
title_full_unstemmed Exploring Urban Green Spaces' Effect against Traffic Exposure on Childhood Leukaemia Incidence
title_sort Exploring Urban Green Spaces' Effect against Traffic Exposure on Childhood Leukaemia Incidence
dc.creator.none.fl_str_mv Ojeda Sánchez, Carlos
García-Pérez, Javier
Gomez-Barroso, Diana
Domínguez-Castillo, Alejandro
Pardo Romaguera, Elena
Cañete, Adela
Ortega-García, Juan Antonio
Ramis, Rebeca
author Ojeda Sánchez, Carlos
author_facet Ojeda Sánchez, Carlos
García-Pérez, Javier
Gomez-Barroso, Diana
Domínguez-Castillo, Alejandro
Pardo Romaguera, Elena
Cañete, Adela
Ortega-García, Juan Antonio
Ramis, Rebeca
author_role author
author2 García-Pérez, Javier
Gomez-Barroso, Diana
Domínguez-Castillo, Alejandro
Pardo Romaguera, Elena
Cañete, Adela
Ortega-García, Juan Antonio
Ramis, Rebeca
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
dc.subject.none.fl_str_mv Parks, Recreational
Leukemia, Myeloid, Acute
Child
Infant
Female
Humans
Incidence
Case-Control Studies
Housing
Environmental Exposure
topic Parks, Recreational
Leukemia, Myeloid, Acute
Child
Infant
Female
Humans
Incidence
Case-Control Studies
Housing
Environmental Exposure
description Background: Several environmental factors seem to be involved in childhood leukaemia incidence. Traffic exposure could increase the risk while urban green spaces (UGS) exposure could reduce it. However, there is no evidence how these two factors interact on this infant pathology. Objectives: to evaluate how residential proximity to UGS could be an environmental protective factor against traffic exposure on childhood leukaemia incidence. Methods: A population-based case control study was conducted across thirty Spanish regions during the period 2000-2018. It included 2526 incident cases and 15,156, individually matched by sex, year-of-birth, and place-of-residence. Using the geographical coordinates of the participants' home residences, a 500 m proxy for exposure to UGS was built. Annual average daily traffic (AADT) was estimated for all types of roads 100 m near the children's residence. Odds ratios (ORs) and 95% confidence intervals (95% CIs), UGS, traffic exposure, and their possible interactions were calculated for overall childhood leukaemia, and the acute lymphoblastic (ALL) and acute myeloblastic leukaemia (AML) subtypes, with adjustment for socio-demographic covariates. Results: We found an increment of childhood leukaemia incidence related to traffic exposure, for every 100 AADT increase the incidence raised 1.1% (95% CI: 0.58-1.61%). UGS exposure showed an incidence reduction for the highest exposure level, Q5 (OR = 0.63; 95% CI = 0.54-0.72). Regression models with both traffic exposure and UGS exposure variables showed similar results but the interaction was not significant. Conclusions: Despite their opposite effects on childhood leukaemia incidence individually, our results do not suggest a possible interaction between both exposures. This is the first study about the interaction of these two environmental factors; consequently, it is necessary to continue taking into account more individualized data and other possible environmental risk factors involved.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-12-13
2023
2023-01-31
2023
2023-01-31
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/16788
url http://hdl.handle.net/20.500.12105/16788
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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