Hepatitis B and A vaccination in HIV-infected adults: A review

Hepatitis B and A account for considerable morbidity and mortality worldwide. Immunization is the most effective means of preventing hepatitis B and A. However, the immune response to both hepatitis vaccines seems to be reduced in HIV-infected subjects. The aim of this review was to analyze the immu...

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Detalles Bibliográficos
Autores: Mena, Guillermo, García-Basteiro, Alberto L., Bayas Rodríguez, José María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/69220
Acceso en línea:https://hdl.handle.net/2445/69220
Access Level:acceso abierto
Palabra clave:Hepatitis A
Hepatitis B
Malalts de sida
AIDS patients
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spelling Hepatitis B and A vaccination in HIV-infected adults: A reviewMena, GuillermoGarcía-Basteiro, Alberto L.Bayas Rodríguez, José MaríaHepatitis AHepatitis BMalalts de sidaHepatitis AHepatitis BAIDS patientsHepatitis B and A account for considerable morbidity and mortality worldwide. Immunization is the most effective means of preventing hepatitis B and A. However, the immune response to both hepatitis vaccines seems to be reduced in HIV-infected subjects. The aim of this review was to analyze the immunogenicity, safety, long-term protection and current recommendations of hepatitis B and A vaccination among HIV-infected adults. The factors most frequently associated with a deficient level of anti-HBs or IgG anti-HAV after vaccination are those related to immunosuppression (CD4 level and HIV RNA viral load) and to the frequency of administration and/or the amount of antigenic load per dose. The duration of the response to both HBV and HAV vaccines is associated with suppression of the viral load at vaccination and, in the case of HBV vaccination, with a higher level of antibodies after vaccination. In terms of safety, there is no evidence of more, or different, adverse effects compared with HIV-free individuals. Despite literature-based advice on the administration of alternative schedules, revaccination after the failure of primary vaccination, and the need for periodic re-evaluation of antibody levels, few firm recommendations are found in the leading guidelines.Taylor & Francis Group2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/69220Articles publicats en revistes (ISGlobal)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1080/21645515.2015.1055424Human Vaccines & Immunotherapeutics, 2015, vol. 11, num. 11, p. 2582-2598http://dx.doi.org/10.1080/21645515.2015.1055424cc by-nc (c) Mena et al., 2015http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/692202026-05-27T06:46:51Z
dc.title.none.fl_str_mv Hepatitis B and A vaccination in HIV-infected adults: A review
title Hepatitis B and A vaccination in HIV-infected adults: A review
spellingShingle Hepatitis B and A vaccination in HIV-infected adults: A review
Mena, Guillermo
Hepatitis A
Hepatitis B
Malalts de sida
Hepatitis A
Hepatitis B
AIDS patients
title_short Hepatitis B and A vaccination in HIV-infected adults: A review
title_full Hepatitis B and A vaccination in HIV-infected adults: A review
title_fullStr Hepatitis B and A vaccination in HIV-infected adults: A review
title_full_unstemmed Hepatitis B and A vaccination in HIV-infected adults: A review
title_sort Hepatitis B and A vaccination in HIV-infected adults: A review
dc.creator.none.fl_str_mv Mena, Guillermo
García-Basteiro, Alberto L.
Bayas Rodríguez, José María
author Mena, Guillermo
author_facet Mena, Guillermo
García-Basteiro, Alberto L.
Bayas Rodríguez, José María
author_role author
author2 García-Basteiro, Alberto L.
Bayas Rodríguez, José María
author2_role author
author
dc.subject.none.fl_str_mv Hepatitis A
Hepatitis B
Malalts de sida
Hepatitis A
Hepatitis B
AIDS patients
topic Hepatitis A
Hepatitis B
Malalts de sida
Hepatitis A
Hepatitis B
AIDS patients
description Hepatitis B and A account for considerable morbidity and mortality worldwide. Immunization is the most effective means of preventing hepatitis B and A. However, the immune response to both hepatitis vaccines seems to be reduced in HIV-infected subjects. The aim of this review was to analyze the immunogenicity, safety, long-term protection and current recommendations of hepatitis B and A vaccination among HIV-infected adults. The factors most frequently associated with a deficient level of anti-HBs or IgG anti-HAV after vaccination are those related to immunosuppression (CD4 level and HIV RNA viral load) and to the frequency of administration and/or the amount of antigenic load per dose. The duration of the response to both HBV and HAV vaccines is associated with suppression of the viral load at vaccination and, in the case of HBV vaccination, with a higher level of antibodies after vaccination. In terms of safety, there is no evidence of more, or different, adverse effects compared with HIV-free individuals. Despite literature-based advice on the administration of alternative schedules, revaccination after the failure of primary vaccination, and the need for periodic re-evaluation of antibody levels, few firm recommendations are found in the leading guidelines.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/69220
url https://hdl.handle.net/2445/69220
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1080/21645515.2015.1055424
Human Vaccines & Immunotherapeutics, 2015, vol. 11, num. 11, p. 2582-2598
http://dx.doi.org/10.1080/21645515.2015.1055424
dc.rights.none.fl_str_mv cc by-nc (c) Mena et al., 2015
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) Mena et al., 2015
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Group
publisher.none.fl_str_mv Taylor & Francis Group
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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