Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation

Primary ventricular fibrillation (PVF) is a major driver of cardiac arrest in the acute phase of ST-segment elevation myocardial infarction (STEMI). Enrichment of cardiomyocyte plasma membranes with dietary polyunsaturated fatty acids (PUFA) reduces vulnerability to PVF experimentally, but clinical...

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Autores: Oliveras, Teresa, Lazaro, Iolanda, Rueda Sobella, Ferran, Cediel, Germán, Bhatt, Deepak L., Fitó Colomer, Montserrat, Madrid Gambín, Francisco Javier, Pozo, Oscar J., Harris, William S., Garcia Garcia, Cosme, Sala Vila, Aleix, Bayés Genís, Antoni
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/186885
Acceso en línea:https://hdl.handle.net/2445/186885
Access Level:acceso abierto
Palabra clave:Infart de miocardi
Fibril·lació ventricular
Myocardial infarction
Ventricular fibrillation
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spelling Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillationOliveras, TeresaLazaro, IolandaRueda Sobella, FerranCediel, GermánBhatt, Deepak L.Fitó Colomer, MontserratMadrid Gambín, Francisco JavierPozo, Oscar J.Harris, William S.Garcia Garcia, CosmeSala Vila, AleixBayés Genís, AntoniInfart de miocardiFibril·lació ventricularMyocardial infarctionVentricular fibrillationPrimary ventricular fibrillation (PVF) is a major driver of cardiac arrest in the acute phase of ST-segment elevation myocardial infarction (STEMI). Enrichment of cardiomyocyte plasma membranes with dietary polyunsaturated fatty acids (PUFA) reduces vulnerability to PVF experimentally, but clinical data are scarce. PUFA status in serum phospholipids is a valid surrogate biomarker of PUFA status in cardiomyocytes within a wide range of dietary PUFA. In this nested case-control study (n = 58 cases of STEMI-driven PVF, n = 116 control non-PVF STEMI patients matched for age, sex, smoking status, dyslipidemia, diabetes mellitus and hypertension) we determined fatty acids in serum phospholipids by gas-chromatography, and assessed differences between cases and controls, applying the Benjamini-Hochberg procedure on nominal P-values to control the false discovery rate (FDR). Significant differences between cases and controls were restricted to linoleic acid (LA), with PVF patients showing a lower level (nominal P = 0.002; FDR-corrected P = 0.027). In a conditional logistic regression model, each one standard deviation increase in the proportion of LA was related to a 42% lower prevalence of PVF (odds ratio = 0.58; 95% confidence interval, 0.37, 0.90; P = 0.02). The association lasted after the inclusion of confounders. Thus, regular consumption of LA-rich foods (nuts, oils from seeds) may protect against ischemia-driven malignant arrhythmias.Nature2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfhttps://hdl.handle.net/2445/186885Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41598-022-08453-0Scientific Reports, 2022, vol. 12https://doi.org/10.1038/s41598-022-08453-0cc by (c) Oliveras, Teresa et al, 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1868852026-05-29T05:05:01Z
dc.title.none.fl_str_mv Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation
title Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation
spellingShingle Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation
Oliveras, Teresa
Infart de miocardi
Fibril·lació ventricular
Myocardial infarction
Ventricular fibrillation
title_short Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation
title_full Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation
title_fullStr Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation
title_full_unstemmed Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation
title_sort Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation
dc.creator.none.fl_str_mv Oliveras, Teresa
Lazaro, Iolanda
Rueda Sobella, Ferran
Cediel, Germán
Bhatt, Deepak L.
Fitó Colomer, Montserrat
Madrid Gambín, Francisco Javier
Pozo, Oscar J.
Harris, William S.
Garcia Garcia, Cosme
Sala Vila, Aleix
Bayés Genís, Antoni
author Oliveras, Teresa
author_facet Oliveras, Teresa
Lazaro, Iolanda
Rueda Sobella, Ferran
Cediel, Germán
Bhatt, Deepak L.
Fitó Colomer, Montserrat
Madrid Gambín, Francisco Javier
Pozo, Oscar J.
Harris, William S.
Garcia Garcia, Cosme
Sala Vila, Aleix
Bayés Genís, Antoni
author_role author
author2 Lazaro, Iolanda
Rueda Sobella, Ferran
Cediel, Germán
Bhatt, Deepak L.
Fitó Colomer, Montserrat
Madrid Gambín, Francisco Javier
Pozo, Oscar J.
Harris, William S.
Garcia Garcia, Cosme
Sala Vila, Aleix
Bayés Genís, Antoni
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Infart de miocardi
Fibril·lació ventricular
Myocardial infarction
Ventricular fibrillation
topic Infart de miocardi
Fibril·lació ventricular
Myocardial infarction
Ventricular fibrillation
description Primary ventricular fibrillation (PVF) is a major driver of cardiac arrest in the acute phase of ST-segment elevation myocardial infarction (STEMI). Enrichment of cardiomyocyte plasma membranes with dietary polyunsaturated fatty acids (PUFA) reduces vulnerability to PVF experimentally, but clinical data are scarce. PUFA status in serum phospholipids is a valid surrogate biomarker of PUFA status in cardiomyocytes within a wide range of dietary PUFA. In this nested case-control study (n = 58 cases of STEMI-driven PVF, n = 116 control non-PVF STEMI patients matched for age, sex, smoking status, dyslipidemia, diabetes mellitus and hypertension) we determined fatty acids in serum phospholipids by gas-chromatography, and assessed differences between cases and controls, applying the Benjamini-Hochberg procedure on nominal P-values to control the false discovery rate (FDR). Significant differences between cases and controls were restricted to linoleic acid (LA), with PVF patients showing a lower level (nominal P = 0.002; FDR-corrected P = 0.027). In a conditional logistic regression model, each one standard deviation increase in the proportion of LA was related to a 42% lower prevalence of PVF (odds ratio = 0.58; 95% confidence interval, 0.37, 0.90; P = 0.02). The association lasted after the inclusion of confounders. Thus, regular consumption of LA-rich foods (nuts, oils from seeds) may protect against ischemia-driven malignant arrhythmias.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/186885
url https://hdl.handle.net/2445/186885
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-022-08453-0
Scientific Reports, 2022, vol. 12
https://doi.org/10.1038/s41598-022-08453-0
dc.rights.none.fl_str_mv cc by (c) Oliveras, Teresa et al, 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Oliveras, Teresa et al, 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8 p.
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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