Catheter-Directed Therapies in Patients with Pulmonary Embolism: Predictive Factors of In-Hospital Mortality and Long-Term Follow-Up

Background: catheter-directed therapies (CDT) may be considered for selected patients with pulmonary embolism (PE). Methods: retrospective observational study including all consecutive patients with acute PE undergoing CDT (mechanical or pharmacomechanical) from January 2010 through December 2020. T...

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Autores: Ribas, Jesús, Valcárcel, Joana, Alba, Esther, Ruíz, Yolanda, Cuartero, Daniel, Iriarte, Adriana, Mora Luján, José María, Huguet, Marta, Cerdà, Pau, Martínez Yélamos, Sergio, Corbella, Xavier, Santos, Salud, Riera Mestre, Antoni
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/181333
Acceso en línea:https://hdl.handle.net/2445/181333
Access Level:acceso abierto
Palabra clave:Embòlia pulmonar
Mortalitat
Catèters
Pulmonary embolism
Mortality
Catheters
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spelling Catheter-Directed Therapies in Patients with Pulmonary Embolism: Predictive Factors of In-Hospital Mortality and Long-Term Follow-UpRibas, JesúsValcárcel, JoanaAlba, EstherRuíz, YolandaCuartero, DanielIriarte, AdrianaMora Luján, José MaríaHuguet, MartaCerdà, PauMartínez Yélamos, SergioCorbella, XavierSantos, SaludRiera Mestre, AntoniEmbòlia pulmonarMortalitatCatètersPulmonary embolismMortalityCathetersBackground: catheter-directed therapies (CDT) may be considered for selected patients with pulmonary embolism (PE). Methods: retrospective observational study including all consecutive patients with acute PE undergoing CDT (mechanical or pharmacomechanical) from January 2010 through December 2020. The aim was to evaluate in-hospital and long-term mortality and its predictive factors. Results: we included 63 patients, 43 (68.3%) with high-risk PE. All patients underwent mechanical CDT and, additionally, 27 (43%) underwent catheter-directed thrombolysis. Twelve (19%) patients received failed systemic thrombolysis (ST) prior to CDT, and an inferior vena cava (IVC) filter was inserted in 28 (44.5%) patients. In-hospital PE-related and all-cause mortality rates were 31.7%; 95% CI 20.6-44.7% and 42.9%; 95% CI 30.5-56%, respectively. In multivariate analysis, age > 70 years and previous ST were strongly associated with PE-related and all-cause mortality, while IVC filter insertion during the CDT was associated with lower mortality rates. After a median follow-up of 40 (12-60) months, 11 more patients died (mortality rate of 60.3%; 95% CI 47.2-72.4%). Long-term survival was significantly higher in patients who received an IVC filter. Conclusions: age > 70 years and failure of previous ST were associated with mortality in acute PE patients treated with CDT. In-hospital and long-term mortality were lower in patients who received IVC filter insertion.MDPI AG2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2445/181333Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/jcm10204716Journal of Clinical Medicine, 2021, vol. 10, num. 20, p. 4716https://doi.org/10.3390/jcm10204716cc-by (c) Ribas, Jesús et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1813332026-05-27T06:46:51Z
dc.title.none.fl_str_mv Catheter-Directed Therapies in Patients with Pulmonary Embolism: Predictive Factors of In-Hospital Mortality and Long-Term Follow-Up
title Catheter-Directed Therapies in Patients with Pulmonary Embolism: Predictive Factors of In-Hospital Mortality and Long-Term Follow-Up
spellingShingle Catheter-Directed Therapies in Patients with Pulmonary Embolism: Predictive Factors of In-Hospital Mortality and Long-Term Follow-Up
Ribas, Jesús
Embòlia pulmonar
Mortalitat
Catèters
Pulmonary embolism
Mortality
Catheters
title_short Catheter-Directed Therapies in Patients with Pulmonary Embolism: Predictive Factors of In-Hospital Mortality and Long-Term Follow-Up
title_full Catheter-Directed Therapies in Patients with Pulmonary Embolism: Predictive Factors of In-Hospital Mortality and Long-Term Follow-Up
title_fullStr Catheter-Directed Therapies in Patients with Pulmonary Embolism: Predictive Factors of In-Hospital Mortality and Long-Term Follow-Up
title_full_unstemmed Catheter-Directed Therapies in Patients with Pulmonary Embolism: Predictive Factors of In-Hospital Mortality and Long-Term Follow-Up
title_sort Catheter-Directed Therapies in Patients with Pulmonary Embolism: Predictive Factors of In-Hospital Mortality and Long-Term Follow-Up
dc.creator.none.fl_str_mv Ribas, Jesús
Valcárcel, Joana
Alba, Esther
Ruíz, Yolanda
Cuartero, Daniel
Iriarte, Adriana
Mora Luján, José María
Huguet, Marta
Cerdà, Pau
Martínez Yélamos, Sergio
Corbella, Xavier
Santos, Salud
Riera Mestre, Antoni
author Ribas, Jesús
author_facet Ribas, Jesús
Valcárcel, Joana
Alba, Esther
Ruíz, Yolanda
Cuartero, Daniel
Iriarte, Adriana
Mora Luján, José María
Huguet, Marta
Cerdà, Pau
Martínez Yélamos, Sergio
Corbella, Xavier
Santos, Salud
Riera Mestre, Antoni
author_role author
author2 Valcárcel, Joana
Alba, Esther
Ruíz, Yolanda
Cuartero, Daniel
Iriarte, Adriana
Mora Luján, José María
Huguet, Marta
Cerdà, Pau
Martínez Yélamos, Sergio
Corbella, Xavier
Santos, Salud
Riera Mestre, Antoni
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Embòlia pulmonar
Mortalitat
Catèters
Pulmonary embolism
Mortality
Catheters
topic Embòlia pulmonar
Mortalitat
Catèters
Pulmonary embolism
Mortality
Catheters
description Background: catheter-directed therapies (CDT) may be considered for selected patients with pulmonary embolism (PE). Methods: retrospective observational study including all consecutive patients with acute PE undergoing CDT (mechanical or pharmacomechanical) from January 2010 through December 2020. The aim was to evaluate in-hospital and long-term mortality and its predictive factors. Results: we included 63 patients, 43 (68.3%) with high-risk PE. All patients underwent mechanical CDT and, additionally, 27 (43%) underwent catheter-directed thrombolysis. Twelve (19%) patients received failed systemic thrombolysis (ST) prior to CDT, and an inferior vena cava (IVC) filter was inserted in 28 (44.5%) patients. In-hospital PE-related and all-cause mortality rates were 31.7%; 95% CI 20.6-44.7% and 42.9%; 95% CI 30.5-56%, respectively. In multivariate analysis, age > 70 years and previous ST were strongly associated with PE-related and all-cause mortality, while IVC filter insertion during the CDT was associated with lower mortality rates. After a median follow-up of 40 (12-60) months, 11 more patients died (mortality rate of 60.3%; 95% CI 47.2-72.4%). Long-term survival was significantly higher in patients who received an IVC filter. Conclusions: age > 70 years and failure of previous ST were associated with mortality in acute PE patients treated with CDT. In-hospital and long-term mortality were lower in patients who received IVC filter insertion.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/181333
url https://hdl.handle.net/2445/181333
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jcm10204716
Journal of Clinical Medicine, 2021, vol. 10, num. 20, p. 4716
https://doi.org/10.3390/jcm10204716
dc.rights.none.fl_str_mv cc-by (c) Ribas, Jesús et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Ribas, Jesús et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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