Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction

Accumulating evidence has suggested that neurotrophins participate in the pathophysiology of mood disorders. We have developed transgenic mice overexpressing the full-length neurotrophin-3 receptor TrkC (TgNTRK3) in the central nervous system. TgNTRK3 mice show increased anxiety-like behavior and en...

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Autores: Dierssen, Mara|||0000-0003-0853-6865, Gratacòs, Mònica|||0000-0001-7304-7289, Sahún, Ignasi, Martin, Miquel|||0000-0001-7771-611X, Gallego, Xavier, Amador-Arjona, Alejandro, Martínez de Lagrán, María|||0000-0002-0836-6491, Murtra, Patricia, Martí, Eulàlia|||0000-0002-1030-3158, Pujana, Miguel Angel|||0000-0003-3222-4044, Ferrer, Isidro|||0000-0001-9888-8754, Dalfo, Esther|||0000-0003-4677-8515, Martínez-Cué, Carmen, Flórez, Jesús, Torres-Peraza, Jesús F., Alberch i Vié, Jordi|||0000-0002-8684-2721, Maldonado, Rafael|||0000-0002-4359-8773, Fillat, Cristina|||0000-0002-0801-3338, Estivill, Xavier|||0000-0002-0723-2256
Tipo de recurso: artículo
Fecha de publicación:2006
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:166638
Acceso en línea:https://ddd.uab.cat/record/166638
https://dx.doi.org/urn:doi:10.1016/j.nbd.2006.07.015
Access Level:acceso abierto
Palabra clave:Panic disorder
NT-3
TrkC
Anxiety-like behavior
Mouse defense test battery
Locus coeruleus
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oai_identifier_str oai:ddd.uab.cat:166638
network_acronym_str ES
network_name_str España
repository_id_str
spelling Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reactionDierssen, Mara|||0000-0003-0853-6865Gratacòs, Mònica|||0000-0001-7304-7289Sahún, IgnasiMartin, Miquel|||0000-0001-7771-611XGallego, XavierAmador-Arjona, AlejandroMartínez de Lagrán, María|||0000-0002-0836-6491Murtra, PatriciaMartí, Eulàlia|||0000-0002-1030-3158Pujana, Miguel Angel|||0000-0003-3222-4044Ferrer, Isidro|||0000-0001-9888-8754Dalfo, Esther|||0000-0003-4677-8515Martínez-Cué, CarmenFlórez, JesúsTorres-Peraza, Jesús F.Alberch i Vié, Jordi|||0000-0002-8684-2721Maldonado, Rafael|||0000-0002-4359-8773Fillat, Cristina|||0000-0002-0801-3338Estivill, Xavier|||0000-0002-0723-2256Panic disorderNT-3TrkCAnxiety-like behaviorMouse defense test batteryLocus coeruleusAccumulating evidence has suggested that neurotrophins participate in the pathophysiology of mood disorders. We have developed transgenic mice overexpressing the full-length neurotrophin-3 receptor TrkC (TgNTRK3) in the central nervous system. TgNTRK3 mice show increased anxiety-like behavior and enhancement of panic reaction in the mouse defense test battery, along with an increase in the number and density of catecholaminergic (tyrosine hydroxylase positive) neurons in locus coeruleus and substantia nigra. Furthermore, treatment of TgNTRK3 mice with diazepam significantly attenuated the anxiety-like behaviors in the plus maze. These results provide evidence for the involvement of TrkC in the development of noradrenergic neurons in the central nervous system with consequences on anxiety-like behavior and panic reaction. Thus, changes in TrkC expression levels could contribute to the phenotypic expression of panic disorder through a trophic effect on noradrenergic neurons in the locus coeruleus. Our results demonstrate that the elevated NT3-TrkC tone via overexpression of TrkC in the brain may constitute a molecular mechanism for the expression of anxiety and anxiety. 22006-01-0120062006-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/166638https://dx.doi.org/urn:doi:10.1016/j.nbd.2006.07.015reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1666382026-06-06T12:50:31Z
dc.title.none.fl_str_mv Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction
title Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction
spellingShingle Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction
Dierssen, Mara|||0000-0003-0853-6865
Panic disorder
NT-3
TrkC
Anxiety-like behavior
Mouse defense test battery
Locus coeruleus
title_short Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction
title_full Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction
title_fullStr Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction
title_full_unstemmed Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction
title_sort Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction
dc.creator.none.fl_str_mv Dierssen, Mara|||0000-0003-0853-6865
Gratacòs, Mònica|||0000-0001-7304-7289
Sahún, Ignasi
Martin, Miquel|||0000-0001-7771-611X
Gallego, Xavier
Amador-Arjona, Alejandro
Martínez de Lagrán, María|||0000-0002-0836-6491
Murtra, Patricia
Martí, Eulàlia|||0000-0002-1030-3158
Pujana, Miguel Angel|||0000-0003-3222-4044
Ferrer, Isidro|||0000-0001-9888-8754
Dalfo, Esther|||0000-0003-4677-8515
Martínez-Cué, Carmen
Flórez, Jesús
Torres-Peraza, Jesús F.
Alberch i Vié, Jordi|||0000-0002-8684-2721
Maldonado, Rafael|||0000-0002-4359-8773
Fillat, Cristina|||0000-0002-0801-3338
Estivill, Xavier|||0000-0002-0723-2256
author Dierssen, Mara|||0000-0003-0853-6865
author_facet Dierssen, Mara|||0000-0003-0853-6865
Gratacòs, Mònica|||0000-0001-7304-7289
Sahún, Ignasi
Martin, Miquel|||0000-0001-7771-611X
Gallego, Xavier
Amador-Arjona, Alejandro
Martínez de Lagrán, María|||0000-0002-0836-6491
Murtra, Patricia
Martí, Eulàlia|||0000-0002-1030-3158
Pujana, Miguel Angel|||0000-0003-3222-4044
Ferrer, Isidro|||0000-0001-9888-8754
Dalfo, Esther|||0000-0003-4677-8515
Martínez-Cué, Carmen
Flórez, Jesús
Torres-Peraza, Jesús F.
Alberch i Vié, Jordi|||0000-0002-8684-2721
Maldonado, Rafael|||0000-0002-4359-8773
Fillat, Cristina|||0000-0002-0801-3338
Estivill, Xavier|||0000-0002-0723-2256
author_role author
author2 Gratacòs, Mònica|||0000-0001-7304-7289
Sahún, Ignasi
Martin, Miquel|||0000-0001-7771-611X
Gallego, Xavier
Amador-Arjona, Alejandro
Martínez de Lagrán, María|||0000-0002-0836-6491
Murtra, Patricia
Martí, Eulàlia|||0000-0002-1030-3158
Pujana, Miguel Angel|||0000-0003-3222-4044
Ferrer, Isidro|||0000-0001-9888-8754
Dalfo, Esther|||0000-0003-4677-8515
Martínez-Cué, Carmen
Flórez, Jesús
Torres-Peraza, Jesús F.
Alberch i Vié, Jordi|||0000-0002-8684-2721
Maldonado, Rafael|||0000-0002-4359-8773
Fillat, Cristina|||0000-0002-0801-3338
Estivill, Xavier|||0000-0002-0723-2256
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Panic disorder
NT-3
TrkC
Anxiety-like behavior
Mouse defense test battery
Locus coeruleus
topic Panic disorder
NT-3
TrkC
Anxiety-like behavior
Mouse defense test battery
Locus coeruleus
description Accumulating evidence has suggested that neurotrophins participate in the pathophysiology of mood disorders. We have developed transgenic mice overexpressing the full-length neurotrophin-3 receptor TrkC (TgNTRK3) in the central nervous system. TgNTRK3 mice show increased anxiety-like behavior and enhancement of panic reaction in the mouse defense test battery, along with an increase in the number and density of catecholaminergic (tyrosine hydroxylase positive) neurons in locus coeruleus and substantia nigra. Furthermore, treatment of TgNTRK3 mice with diazepam significantly attenuated the anxiety-like behaviors in the plus maze. These results provide evidence for the involvement of TrkC in the development of noradrenergic neurons in the central nervous system with consequences on anxiety-like behavior and panic reaction. Thus, changes in TrkC expression levels could contribute to the phenotypic expression of panic disorder through a trophic effect on noradrenergic neurons in the locus coeruleus. Our results demonstrate that the elevated NT3-TrkC tone via overexpression of TrkC in the brain may constitute a molecular mechanism for the expression of anxiety and anxiety.
publishDate 2006
dc.date.none.fl_str_mv 2
2006-01-01
2006
2006-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/166638
https://dx.doi.org/urn:doi:10.1016/j.nbd.2006.07.015
url https://ddd.uab.cat/record/166638
https://dx.doi.org/urn:doi:10.1016/j.nbd.2006.07.015
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
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