Global estimates of human papillomavirus vaccination coverage by region and income level: a pooled analysis

Background: Since 2006, many countries have implemented publicly funded human papillomavirus (HPV) immunisation programmes. However, global estimates of the extent and impact of vaccine coverage are still unavailable. We aimed to quantify worldwide cumulative coverage of publicly funded HPV immunisa...

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Autores: Bruni, Laia, Diaz Sanchis, Mireia, Barrionuevo Rosas, Leslie, Herrero, Rolando, Bray, Freddie, Bosch José, Francesc Xavier, 1947-, Sanjosé Llongueras, Silvia de, Castellsagué, Xavier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/126836
Acceso en línea:https://hdl.handle.net/2445/126836
Access Level:acceso abierto
Palabra clave:Vacuna del papil·lomavirus
Papillomavirus vaccines
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spelling Global estimates of human papillomavirus vaccination coverage by region and income level: a pooled analysisBruni, LaiaDiaz Sanchis, MireiaBarrionuevo Rosas, LeslieHerrero, RolandoBray, FreddieBosch José, Francesc Xavier, 1947-Sanjosé Llongueras, Silvia deCastellsagué, XavierVacuna del papil·lomavirusPapillomavirus vaccinesBackground: Since 2006, many countries have implemented publicly funded human papillomavirus (HPV) immunisation programmes. However, global estimates of the extent and impact of vaccine coverage are still unavailable. We aimed to quantify worldwide cumulative coverage of publicly funded HPV immunisation programmes up to 2014, and the potential impact on future cervical cancer cases and deaths. Methods: Between Nov 1 and Dec 22, 2014, we systematically reviewed PubMed, Scopus, and official websites to identify HPV immunisation programmes worldwide, and retrieved age-specific HPV vaccination coverage rates up to October, 2014. To estimate the coverage and number of vaccinated women, retrieved coverage rates were converted into birth-cohort-specific rates, with an imputation algorithm to impute missing data, and applied to global population estimates and cervical cancer projections by country and income level. Findings: From June, 2006, to October, 2014, 64 countries nationally, four countries subnationally, and 12 overseas territories had implemented HPV immunisation programmes. An estimated 118 million women had been targeted through these programmes, but only 1% were from low-income or lower-middle-income countries. 47 million women (95% CI 39-55 million) received the full course of vaccine, representing a total population coverage of 1.4% (95% CI 1.1-1.6), and 59 million women (48-71 million) had received at least one dose, representing a total population coverage of 1.7% (1.4-2.1). In more developed regions, 33.6% (95% CI 25.9-41.7) of females aged 10-20 years received the full course of vaccine, compared with only 2.7% (1.8-3.6) of females in less developed regions. The impact of the vaccine will be higher in upper-middle-income countries (178 192 averted cases by age 75 years) than in high-income countries (165 033 averted cases), despite the lower number of vaccinated women (13.3 million vs 32.2 million). Interpretation Many women from high-income and upper-middle-income countries have been vaccinated against HPV. However, populations with the highest incidence and mortality of disease remain largely unprotected. Rapid roll-out of the vaccine in low-income and middle-income countries might be the only feasible way to narrow present inequalities in cervical cancer burden and prevention.Elsevier2018201820162018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/126836Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/S2214-109X(16)30099-7Lancet Global Health, 2016, vol. 4, num. 7, p. E453-E463https://doi.org/10.1016/S2214-109X(16)30099-7cc by (c) Bruni et al., 2016http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1268362026-05-29T05:05:01Z
dc.title.none.fl_str_mv Global estimates of human papillomavirus vaccination coverage by region and income level: a pooled analysis
title Global estimates of human papillomavirus vaccination coverage by region and income level: a pooled analysis
spellingShingle Global estimates of human papillomavirus vaccination coverage by region and income level: a pooled analysis
Bruni, Laia
Vacuna del papil·lomavirus
Papillomavirus vaccines
title_short Global estimates of human papillomavirus vaccination coverage by region and income level: a pooled analysis
title_full Global estimates of human papillomavirus vaccination coverage by region and income level: a pooled analysis
title_fullStr Global estimates of human papillomavirus vaccination coverage by region and income level: a pooled analysis
title_full_unstemmed Global estimates of human papillomavirus vaccination coverage by region and income level: a pooled analysis
title_sort Global estimates of human papillomavirus vaccination coverage by region and income level: a pooled analysis
dc.creator.none.fl_str_mv Bruni, Laia
Diaz Sanchis, Mireia
Barrionuevo Rosas, Leslie
Herrero, Rolando
Bray, Freddie
Bosch José, Francesc Xavier, 1947-
Sanjosé Llongueras, Silvia de
Castellsagué, Xavier
author Bruni, Laia
author_facet Bruni, Laia
Diaz Sanchis, Mireia
Barrionuevo Rosas, Leslie
Herrero, Rolando
Bray, Freddie
Bosch José, Francesc Xavier, 1947-
Sanjosé Llongueras, Silvia de
Castellsagué, Xavier
author_role author
author2 Diaz Sanchis, Mireia
Barrionuevo Rosas, Leslie
Herrero, Rolando
Bray, Freddie
Bosch José, Francesc Xavier, 1947-
Sanjosé Llongueras, Silvia de
Castellsagué, Xavier
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Vacuna del papil·lomavirus
Papillomavirus vaccines
topic Vacuna del papil·lomavirus
Papillomavirus vaccines
description Background: Since 2006, many countries have implemented publicly funded human papillomavirus (HPV) immunisation programmes. However, global estimates of the extent and impact of vaccine coverage are still unavailable. We aimed to quantify worldwide cumulative coverage of publicly funded HPV immunisation programmes up to 2014, and the potential impact on future cervical cancer cases and deaths. Methods: Between Nov 1 and Dec 22, 2014, we systematically reviewed PubMed, Scopus, and official websites to identify HPV immunisation programmes worldwide, and retrieved age-specific HPV vaccination coverage rates up to October, 2014. To estimate the coverage and number of vaccinated women, retrieved coverage rates were converted into birth-cohort-specific rates, with an imputation algorithm to impute missing data, and applied to global population estimates and cervical cancer projections by country and income level. Findings: From June, 2006, to October, 2014, 64 countries nationally, four countries subnationally, and 12 overseas territories had implemented HPV immunisation programmes. An estimated 118 million women had been targeted through these programmes, but only 1% were from low-income or lower-middle-income countries. 47 million women (95% CI 39-55 million) received the full course of vaccine, representing a total population coverage of 1.4% (95% CI 1.1-1.6), and 59 million women (48-71 million) had received at least one dose, representing a total population coverage of 1.7% (1.4-2.1). In more developed regions, 33.6% (95% CI 25.9-41.7) of females aged 10-20 years received the full course of vaccine, compared with only 2.7% (1.8-3.6) of females in less developed regions. The impact of the vaccine will be higher in upper-middle-income countries (178 192 averted cases by age 75 years) than in high-income countries (165 033 averted cases), despite the lower number of vaccinated women (13.3 million vs 32.2 million). Interpretation Many women from high-income and upper-middle-income countries have been vaccinated against HPV. However, populations with the highest incidence and mortality of disease remain largely unprotected. Rapid roll-out of the vaccine in low-income and middle-income countries might be the only feasible way to narrow present inequalities in cervical cancer burden and prevention.
publishDate 2016
dc.date.none.fl_str_mv 2016
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126836
url https://hdl.handle.net/2445/126836
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/S2214-109X(16)30099-7
Lancet Global Health, 2016, vol. 4, num. 7, p. E453-E463
https://doi.org/10.1016/S2214-109X(16)30099-7
dc.rights.none.fl_str_mv cc by (c) Bruni et al., 2016
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Bruni et al., 2016
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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