The Predictive Value of Lung Ultrasound Scores in Developing Bronchopulmonary Dysplasia

Background: Different lung ultrasound (LUS) scanning protocols have been used, and the results in terms of diagnostic accuracy are heterogeneous. Research questions: What is the diagnostic accuracy of the LUS score to predict moderate to severe bronchopulmonary dysplasia (msBPD)? Does scanning of po...

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Autores: Alonso-Ojembarrena, Almudena, Serna-Guerediaga, Iker, Aldecoa-Bilbao, Victoria, Gregorio-Hernández, Rebeca, Alonso-Quintela, Paula, Concheiro Guisán, Ana, Ramos-Rodríguez, Alicia, Heras-Martín, Mónica de las, Rodeño-Fernández, Lorena, Oulego-Erroz, Ignacio
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/38519
Acceso en línea:https://hdl.handle.net/10347/38519
Access Level:acceso abierto
Palabra clave:Biomarker
Bronchopulmonary dysplasia
Lung diagnostic imaging
Preterm
Ultrasound
32 Ciencias médicas
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spelling The Predictive Value of Lung Ultrasound Scores in Developing Bronchopulmonary DysplasiaAlonso-Ojembarrena, AlmudenaSerna-Guerediaga, IkerAldecoa-Bilbao, VictoriaGregorio-Hernández, RebecaAlonso-Quintela, PaulaConcheiro Guisán, AnaRamos-Rodríguez, AliciaHeras-Martín, Mónica de lasRodeño-Fernández, LorenaOulego-Erroz, IgnacioBiomarkerBronchopulmonary dysplasiaLung diagnostic imagingPretermUltrasound32 Ciencias médicasBackground: Different lung ultrasound (LUS) scanning protocols have been used, and the results in terms of diagnostic accuracy are heterogeneous. Research questions: What is the diagnostic accuracy of the LUS score to predict moderate to severe bronchopulmonary dysplasia (msBPD)? Does scanning of posterior lung fields improve the diagnostic accuracy? Study design and methods: This was a multicenter prospective, observational study in six centers. Two LUS aeration scores, one involving only anterolateral lung fields and the other adding the posterior fields were obtained at birth, on the third day of life (DOL), on the seventh DOL, on the 14th DOL, and on the 21st DOL. The diagnostic accuracy of both scores to predict msBPD was assessed at each time point. Results: Eight hundred thirty-two LUS examinations in 298 infants were included. Both LUS score using anterolateral and posterior fields and LUS score using only anterolateral fields showed a similar moderate diagnostic accuracy to predict msBPD on the third DOL (area under the receiver operating characteristic curve [AUC] 95% CI, 0.68-0.85 vs 0.68-0.85; P = .97), seventh DOL (AUC 95% CI, 0.74-0.85 vs 0.74-0.84; P = .26), and 21st DOL (AUC 95% CI, 0.72-0.86 vs 0.74-0.88; P = .17). The LUS score using anterolateral and posterior fields was slightly more accurate at 14th DOL (AUC 95% CI, 0.69-0.83 vs 0.66-0.80; P = .01). A cutoff of 8 points in the LUS score using only anterolateral fields on the seventh DOL provided a sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of 70%, 79%, 3.3, and 0.38, respectively, to predict msBPD. Adding gestational age (GA) and sex improved the discriminative value without significant differences compared with a predictive model based on multiple clinical variables: AUC 95% CI, 0.77-0.88 vs 0.80-0.91 (P = .52). Interpretation: The LUS score is able to predict msBPD from the third DOL with a moderate diagnostic accuracy. Scanning posterior lung fields slightly improved diagnostic accuracy only at the 14th DOL. Adding GA and sex improves the diagnostic accuracy of the LUS scores. The LUS score is useful to stratify BPD risk early after birth.ElsevierUniversidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría20212021-09-0120212021-09-01journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/38519reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/385192026-06-15T12:47:27Z
dc.title.none.fl_str_mv The Predictive Value of Lung Ultrasound Scores in Developing Bronchopulmonary Dysplasia
title The Predictive Value of Lung Ultrasound Scores in Developing Bronchopulmonary Dysplasia
spellingShingle The Predictive Value of Lung Ultrasound Scores in Developing Bronchopulmonary Dysplasia
Alonso-Ojembarrena, Almudena
Biomarker
Bronchopulmonary dysplasia
Lung diagnostic imaging
Preterm
Ultrasound
32 Ciencias médicas
title_short The Predictive Value of Lung Ultrasound Scores in Developing Bronchopulmonary Dysplasia
title_full The Predictive Value of Lung Ultrasound Scores in Developing Bronchopulmonary Dysplasia
title_fullStr The Predictive Value of Lung Ultrasound Scores in Developing Bronchopulmonary Dysplasia
title_full_unstemmed The Predictive Value of Lung Ultrasound Scores in Developing Bronchopulmonary Dysplasia
title_sort The Predictive Value of Lung Ultrasound Scores in Developing Bronchopulmonary Dysplasia
dc.creator.none.fl_str_mv Alonso-Ojembarrena, Almudena
Serna-Guerediaga, Iker
Aldecoa-Bilbao, Victoria
Gregorio-Hernández, Rebeca
Alonso-Quintela, Paula
Concheiro Guisán, Ana
Ramos-Rodríguez, Alicia
Heras-Martín, Mónica de las
Rodeño-Fernández, Lorena
Oulego-Erroz, Ignacio
author Alonso-Ojembarrena, Almudena
author_facet Alonso-Ojembarrena, Almudena
Serna-Guerediaga, Iker
Aldecoa-Bilbao, Victoria
Gregorio-Hernández, Rebeca
Alonso-Quintela, Paula
Concheiro Guisán, Ana
Ramos-Rodríguez, Alicia
Heras-Martín, Mónica de las
Rodeño-Fernández, Lorena
Oulego-Erroz, Ignacio
author_role author
author2 Serna-Guerediaga, Iker
Aldecoa-Bilbao, Victoria
Gregorio-Hernández, Rebeca
Alonso-Quintela, Paula
Concheiro Guisán, Ana
Ramos-Rodríguez, Alicia
Heras-Martín, Mónica de las
Rodeño-Fernández, Lorena
Oulego-Erroz, Ignacio
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría
dc.subject.none.fl_str_mv Biomarker
Bronchopulmonary dysplasia
Lung diagnostic imaging
Preterm
Ultrasound
32 Ciencias médicas
topic Biomarker
Bronchopulmonary dysplasia
Lung diagnostic imaging
Preterm
Ultrasound
32 Ciencias médicas
description Background: Different lung ultrasound (LUS) scanning protocols have been used, and the results in terms of diagnostic accuracy are heterogeneous. Research questions: What is the diagnostic accuracy of the LUS score to predict moderate to severe bronchopulmonary dysplasia (msBPD)? Does scanning of posterior lung fields improve the diagnostic accuracy? Study design and methods: This was a multicenter prospective, observational study in six centers. Two LUS aeration scores, one involving only anterolateral lung fields and the other adding the posterior fields were obtained at birth, on the third day of life (DOL), on the seventh DOL, on the 14th DOL, and on the 21st DOL. The diagnostic accuracy of both scores to predict msBPD was assessed at each time point. Results: Eight hundred thirty-two LUS examinations in 298 infants were included. Both LUS score using anterolateral and posterior fields and LUS score using only anterolateral fields showed a similar moderate diagnostic accuracy to predict msBPD on the third DOL (area under the receiver operating characteristic curve [AUC] 95% CI, 0.68-0.85 vs 0.68-0.85; P = .97), seventh DOL (AUC 95% CI, 0.74-0.85 vs 0.74-0.84; P = .26), and 21st DOL (AUC 95% CI, 0.72-0.86 vs 0.74-0.88; P = .17). The LUS score using anterolateral and posterior fields was slightly more accurate at 14th DOL (AUC 95% CI, 0.69-0.83 vs 0.66-0.80; P = .01). A cutoff of 8 points in the LUS score using only anterolateral fields on the seventh DOL provided a sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of 70%, 79%, 3.3, and 0.38, respectively, to predict msBPD. Adding gestational age (GA) and sex improved the discriminative value without significant differences compared with a predictive model based on multiple clinical variables: AUC 95% CI, 0.77-0.88 vs 0.80-0.91 (P = .52). Interpretation: The LUS score is able to predict msBPD from the third DOL with a moderate diagnostic accuracy. Scanning posterior lung fields slightly improved diagnostic accuracy only at the 14th DOL. Adding GA and sex improves the diagnostic accuracy of the LUS scores. The LUS score is useful to stratify BPD risk early after birth.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-09-01
2021
2021-09-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/38519
url https://hdl.handle.net/10347/38519
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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