Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles

The magnetic properties and safety of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) have facilitated their clinical use as MRI contrast agents and stimulated research on applications for SPIONs in particle imaging and magnetic hyperthermia. The wider clinical potential of SPIONs...

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Autores: Abdollah, Maha R. A., Carter, Thomas J., Jones, Clare, Kalber, Tammy L., Rajkumar, Vineeth, Tolner, Berend, Gruettner, Cordula, Zaw-Thin, May, Baguña Torres, Júlia, Ellis, Matthew, Robson, Mathew, Pedley, R Barbara, Mulholland, Paul, Rosales, Rafael T. M. de, Chester, Kerry Ann
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/419829
Acceso en línea:http://hdl.handle.net/10261/419829
https://api.elsevier.com/content/abstract/scopus_id/85042723010
Access Level:acceso abierto
Palabra clave:Superparamagnetic iron oxide nanoparticles (SPIONs)
Ferucarbotran
Reticuloendothelial system (RES)
Dextran
Fucoidan
Single-photon emission computed tomography (SPECT
Positron emission tomography (PET)
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dc.title.none.fl_str_mv Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles
title Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles
spellingShingle Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles
Abdollah, Maha R. A.
Superparamagnetic iron oxide nanoparticles (SPIONs)
Ferucarbotran
Reticuloendothelial system (RES)
Dextran
Fucoidan
Single-photon emission computed tomography (SPECT
Positron emission tomography (PET)
title_short Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles
title_full Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles
title_fullStr Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles
title_full_unstemmed Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles
title_sort Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles
dc.creator.none.fl_str_mv Abdollah, Maha R. A.
Carter, Thomas J.
Jones, Clare
Kalber, Tammy L.
Rajkumar, Vineeth
Tolner, Berend
Gruettner, Cordula
Zaw-Thin, May
Baguña Torres, Júlia
Ellis, Matthew
Robson, Mathew
Pedley, R Barbara
Mulholland, Paul
Rosales, Rafael T. M. de
Chester, Kerry Ann
author Abdollah, Maha R. A.
author_facet Abdollah, Maha R. A.
Carter, Thomas J.
Jones, Clare
Kalber, Tammy L.
Rajkumar, Vineeth
Tolner, Berend
Gruettner, Cordula
Zaw-Thin, May
Baguña Torres, Júlia
Ellis, Matthew
Robson, Mathew
Pedley, R Barbara
Mulholland, Paul
Rosales, Rafael T. M. de
Chester, Kerry Ann
author_role author
author2 Carter, Thomas J.
Jones, Clare
Kalber, Tammy L.
Rajkumar, Vineeth
Tolner, Berend
Gruettner, Cordula
Zaw-Thin, May
Baguña Torres, Júlia
Ellis, Matthew
Robson, Mathew
Pedley, R Barbara
Mulholland, Paul
Rosales, Rafael T. M. de
Chester, Kerry Ann
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Cancer Research UK
Engineering and Physical Sciences Research Council (UK)
British Council
Department for Business, Energy and Industrial Strategy (UK)
Wellcome Trust
National Institute for Health Research (UK)
Guy's & St Thomas' Foundation
NHS Foundation Trust
University College London
dc.subject.none.fl_str_mv Superparamagnetic iron oxide nanoparticles (SPIONs)
Ferucarbotran
Reticuloendothelial system (RES)
Dextran
Fucoidan
Single-photon emission computed tomography (SPECT
Positron emission tomography (PET)
topic Superparamagnetic iron oxide nanoparticles (SPIONs)
Ferucarbotran
Reticuloendothelial system (RES)
Dextran
Fucoidan
Single-photon emission computed tomography (SPECT
Positron emission tomography (PET)
description The magnetic properties and safety of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) have facilitated their clinical use as MRI contrast agents and stimulated research on applications for SPIONs in particle imaging and magnetic hyperthermia. The wider clinical potential of SPIONs, however, has been limited by their rapid removal from circulation via the reticuloendothelial system (RES). We explored the possibility of extending SPION circulatory time using fucoidan, a seaweed-derived food supplement, to inhibit RES uptake. The effects of fucoidan on SPION biodistribution were evaluated using ferucarbotran, which in its pharmaceutical formulation (Resovist) targets the RES. Ferucarbotran was radiolabeled at the iron oxide core with technetium-99m (99mTc; t1/2 = 6 h) or zirconium-89 (89Zr; t1/2 = 3.3 days). Results obtained with 99mTc-ferucarbotran demonstrated that administration of fucoidan led to a 4-fold increase in the circulatory half-life (t1/2 slow) from 37.4 to 150 min (n = 4; P < 0.0001). To investigate whether a longer circulatory half-life could lead to concomitant increased tumor uptake, the effects of fucoidan were tested with 89Zr-ferucarbotran in mice bearing syngeneic subcutaneous (GL261) tumors. In this model, the longer circulatory half-life achieved with fucoidan was associated with a doubling in tumor SPION uptake (n = 5; P < 0.001). Fucoidan was also effective in significantly increasing the circulatory half-life of perimag-COOH, a commercially available SPION with a larger hydrodynamic size (130 nm) than ferucarbotran (65 nm). These findings indicate successful diversion of SPIONs away from the hepatic RES and show realistic potential for future clinical applications.
publishDate 2018
dc.date.none.fl_str_mv 2018
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/419829
https://api.elsevier.com/content/abstract/scopus_id/85042723010
url http://hdl.handle.net/10261/419829
https://api.elsevier.com/content/abstract/scopus_id/85042723010
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/278580
https://doi.org/10.1021/acsnano.7b06734
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide NanoparticlesAbdollah, Maha R. A.Carter, Thomas J.Jones, ClareKalber, Tammy L.Rajkumar, VineethTolner, BerendGruettner, CordulaZaw-Thin, MayBaguña Torres, JúliaEllis, MatthewRobson, MathewPedley, R BarbaraMulholland, PaulRosales, Rafael T. M. deChester, Kerry AnnSuperparamagnetic iron oxide nanoparticles (SPIONs)FerucarbotranReticuloendothelial system (RES)DextranFucoidanSingle-photon emission computed tomography (SPECTPositron emission tomography (PET)The magnetic properties and safety of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) have facilitated their clinical use as MRI contrast agents and stimulated research on applications for SPIONs in particle imaging and magnetic hyperthermia. The wider clinical potential of SPIONs, however, has been limited by their rapid removal from circulation via the reticuloendothelial system (RES). We explored the possibility of extending SPION circulatory time using fucoidan, a seaweed-derived food supplement, to inhibit RES uptake. The effects of fucoidan on SPION biodistribution were evaluated using ferucarbotran, which in its pharmaceutical formulation (Resovist) targets the RES. Ferucarbotran was radiolabeled at the iron oxide core with technetium-99m (99mTc; t1/2 = 6 h) or zirconium-89 (89Zr; t1/2 = 3.3 days). Results obtained with 99mTc-ferucarbotran demonstrated that administration of fucoidan led to a 4-fold increase in the circulatory half-life (t1/2 slow) from 37.4 to 150 min (n = 4; P < 0.0001). To investigate whether a longer circulatory half-life could lead to concomitant increased tumor uptake, the effects of fucoidan were tested with 89Zr-ferucarbotran in mice bearing syngeneic subcutaneous (GL261) tumors. In this model, the longer circulatory half-life achieved with fucoidan was associated with a doubling in tumor SPION uptake (n = 5; P < 0.001). Fucoidan was also effective in significantly increasing the circulatory half-life of perimag-COOH, a commercially available SPION with a larger hydrodynamic size (130 nm) than ferucarbotran (65 nm). These findings indicate successful diversion of SPIONs away from the hepatic RES and show realistic potential for future clinical applications.The authors acknowledge financial support from the EU Framework 7 Programme DARTRIX project grant no. 278580, the King’s College London and UCL Comprehensive Cancer Imaging Centre funded by Cancer Research UK (CRUK) and EPSRC in association with the MRC and DoH (England), the British Council and the UK Department for Business, Energy and Industrial Strategy under the Institutional Links programme (Application No. 277386067), King’s Health Partners (KHP) Research and Development Challenge Fund award (R160402), The Centre of Excellence in Medical Engineering funded by the Wellcome Trust and EPSRC under Grant No. WT 088641/Z/09/Z, Department of Health via the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy’s & St Thomas’ NHS Foundation Trust and King’s College London, Celia Abrahams and the Mothers and Daughters Committee, the National Brain Appeal, CRUK, Department of Health (ECMC, Experimental Cancer Medicine Network Centre), NIHR University College London Hospitals Biomedical Research Centre, and CRUK Accelerator Grant (Cl 15121 A 20256).Peer reviewedAmerican Chemical SocietyEuropean CommissionCancer Research UKEngineering and Physical Sciences Research Council (UK)British CouncilDepartment for Business, Energy and Industrial Strategy (UK)Wellcome TrustNational Institute for Health Research (UK)Guy's & St Thomas' FoundationNHS Foundation TrustUniversity College London202620262018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttp://hdl.handle.net/10261/419829https://api.elsevier.com/content/abstract/scopus_id/85042723010reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/278580https://doi.org/10.1021/acsnano.7b06734Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4198292026-05-22T06:33:51Z
score 15,811543

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