The Effects of Different Endocrine Disruptors Defining Compound-Specific Alterations of Gene Expression Profiles in the Developing Testis.

10 páginas, 6 figuras, 3 tablas -- PAGS nros. 106-115

Detalles Bibliográficos
Autores: López-Casas, Pedro P., Mizrak, Sefika C., López-Fernández, Luis A., Paz, María, Rooij, Dirk G. de, Del Mazo, Jesús
Tipo de recurso: artículo
Fecha de publicación:2012
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::ecdf55e14b467a46be6ee61e3e2af930
Acceso en línea:http://hdl.handle.net/10261/61018
Access Level:acceso abierto
Palabra clave:Endocrine disruptor
Testis
17β-Estradiol
Lindane
Bisphenol-A
Mono-ethylhexyl phthalate
Zearalenone
DNA microarrays
Gene expression profile
id ES_2f6341897ef3f2956cc3b357756f3e8a
oai_identifier_str oai:dnet:digitalcsic_::ecdf55e14b467a46be6ee61e3e2af930
network_acronym_str ES
network_name_str España
repository_id_str
spelling The Effects of Different Endocrine Disruptors Defining Compound-Specific Alterations of Gene Expression Profiles in the Developing Testis.López-Casas, Pedro P.Mizrak, Sefika C.López-Fernández, Luis A.Paz, MaríaRooij, Dirk G. deDel Mazo, JesúsEndocrine disruptorTestis17β-EstradiolLindaneBisphenol-AMono-ethylhexyl phthalateZearalenoneDNA microarraysGene expression profile10 páginas, 6 figuras, 3 tablas -- PAGS nros. 106-115Environmental contaminants considered endocrine disruptors have been shown to affect testis development and function but the mechanisms of action are not clear. We now have analyzed the effects on the transcriptome in testes of mice exposed to mono-(2-ethylhexyl)-phthalate (9.2; 46.3 or 92.7 mg/kg/d), zearalenone (1.3; 3.9 or 6.6 mg/kg/d), lindane (16.6; 32.2 or 64.4 mg/kg/d), bisphenol-A (0.16; 16 or 64 mg/kg/d) or 17β-estradiol (0.006; 0.012 or 0.048 mg/kg/d). The compounds were orally administered in the drinking water during distinct developmental periods: (A) mothers were exposed only during the two weeks before mating; (B) the exposure was continued during pregnancy until birth or (C) exposure was continued for a further four weeks after birth. Testes were studied at four weeks of age. Mono-(2-ethylhexyl)-phthalate and zearalenone, both produced specific alterations of gene signatures. Interestingly, this was irrespective of the concentration of the toxicant or the developmental period during which exposure occurredThis work was supported by the EC (grant QLK4-CT-2002-02403), CEFIC-LRi, MICINN (FIS PI071007) and PIE (201020E016). LALF was supported by a Miguel Servet grant from Instituto de Salud Carlos III (CP06/00267)Peer reviewedElsevier201220122012info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/61018reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.reprotox.2011.12.012info:eu-repo/semantics/openAccessoai:dnet:digitalcsic_::ecdf55e14b467a46be6ee61e3e2af9302026-05-22T06:33:51Z
dc.title.none.fl_str_mv The Effects of Different Endocrine Disruptors Defining Compound-Specific Alterations of Gene Expression Profiles in the Developing Testis.
title The Effects of Different Endocrine Disruptors Defining Compound-Specific Alterations of Gene Expression Profiles in the Developing Testis.
spellingShingle The Effects of Different Endocrine Disruptors Defining Compound-Specific Alterations of Gene Expression Profiles in the Developing Testis.
López-Casas, Pedro P.
Endocrine disruptor
Testis
17β-Estradiol
Lindane
Bisphenol-A
Mono-ethylhexyl phthalate
Zearalenone
DNA microarrays
Gene expression profile
title_short The Effects of Different Endocrine Disruptors Defining Compound-Specific Alterations of Gene Expression Profiles in the Developing Testis.
title_full The Effects of Different Endocrine Disruptors Defining Compound-Specific Alterations of Gene Expression Profiles in the Developing Testis.
title_fullStr The Effects of Different Endocrine Disruptors Defining Compound-Specific Alterations of Gene Expression Profiles in the Developing Testis.
title_full_unstemmed The Effects of Different Endocrine Disruptors Defining Compound-Specific Alterations of Gene Expression Profiles in the Developing Testis.
title_sort The Effects of Different Endocrine Disruptors Defining Compound-Specific Alterations of Gene Expression Profiles in the Developing Testis.
dc.creator.none.fl_str_mv López-Casas, Pedro P.
Mizrak, Sefika C.
López-Fernández, Luis A.
Paz, María
Rooij, Dirk G. de
Del Mazo, Jesús
author López-Casas, Pedro P.
author_facet López-Casas, Pedro P.
Mizrak, Sefika C.
López-Fernández, Luis A.
Paz, María
Rooij, Dirk G. de
Del Mazo, Jesús
author_role author
author2 Mizrak, Sefika C.
López-Fernández, Luis A.
Paz, María
Rooij, Dirk G. de
Del Mazo, Jesús
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Endocrine disruptor
Testis
17β-Estradiol
Lindane
Bisphenol-A
Mono-ethylhexyl phthalate
Zearalenone
DNA microarrays
Gene expression profile
topic Endocrine disruptor
Testis
17β-Estradiol
Lindane
Bisphenol-A
Mono-ethylhexyl phthalate
Zearalenone
DNA microarrays
Gene expression profile
description 10 páginas, 6 figuras, 3 tablas -- PAGS nros. 106-115
publishDate 2012
dc.date.none.fl_str_mv 2012
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/61018
url http://hdl.handle.net/10261/61018
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.reprotox.2011.12.012
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405474526330880
score 15,811543

Similares en LA Referencia