Population Pharmacokinetic–Pharmacodynamic Analysis of a Reserpine-Induced Myalgia Model in Rats

[Background]: Fibromyalgia syndrome (FMS) is a chronic pain condition with widespread pain and multiple comorbidities, for which conventional therapies offer limited benefits. The reserpine-induced myalgia (RIM) model is an efficient animal model of FMS in rodents. This study aimed to develop a phar...

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Detalles Bibliográficos
Autores: Alfosea-Cuadrado, Gloria M., Zarzoso-Foj, Javier, Adell, Albert, Valverde-Navarro, Alfonso A., González-Soler, Eva M., Mangas-Sanjuán, Víctor, Blasco-Serra, Arantxa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/382563
Acceso en línea:http://hdl.handle.net/10261/382563
Access Level:acceso abierto
Palabra clave:Reserpine
Pharmacokinetic
Pharmacodynamic
Fibromyalgia
Descripción
Sumario:[Background]: Fibromyalgia syndrome (FMS) is a chronic pain condition with widespread pain and multiple comorbidities, for which conventional therapies offer limited benefits. The reserpine-induced myalgia (RIM) model is an efficient animal model of FMS in rodents. This study aimed to develop a pharmacokinetic–pharmacodynamic (PK–PD) model of reserpine in rats, linking to its impact on monoamines (MAs).

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