Candida albicans increases the aerobic glycolysis and activates MAPK–dependent inflammatory response of liver sinusoidal endothelial cells

The liver, and more specifically, the liver sinusoidal endothelial cells, constitute the beginning of one of the most important responses for the elimination of hematogenously disseminated Candida albicans. Therefore, we aimed to study the mechanisms involved in the interaction between these cells a...

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Authors: Aparicio Fernández, Leire, Antorán Díaz, Aitziber, Areitio Beramendi, Maialen, Rodríguez Ereñaga, Oier, Martín Souto, Leire, Buldain Garriz, Idoia, Márquez Clavijo, Joana, Benedicto García, Aitor, Arteta Ruiz, Beatriz, Pellón Rodríguez, Aize, Moyes, David L., Rementeria Ruiz, Aitor Domingo, Ramírez García, Andoni
Format: article
Publication Date:2024
Country:España
Institution:Universidad del País Vasco
Repository:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/68769
Online Access:http://hdl.handle.net/10810/68769
Access Level:Open access
Keyword:liver endothelium
Candida
inflammation
metabolism
immune response
aerobic glycolysis
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spelling Candida albicans increases the aerobic glycolysis and activates MAPK–dependent inflammatory response of liver sinusoidal endothelial cellsAparicio Fernández, LeireAntorán Díaz, AitziberAreitio Beramendi, MaialenRodríguez Ereñaga, OierMartín Souto, LeireBuldain Garriz, IdoiaMárquez Clavijo, JoanaBenedicto García, AitorArteta Ruiz, BeatrizPellón Rodríguez, AizeMoyes, David L.Rementeria Ruiz, Aitor DomingoRamírez García, Andoniliver endotheliumCandidainflammationmetabolismimmune responseaerobic glycolysisThe liver, and more specifically, the liver sinusoidal endothelial cells, constitute the beginning of one of the most important responses for the elimination of hematogenously disseminated Candida albicans. Therefore, we aimed to study the mechanisms involved in the interaction between these cells and C. albicans. Transcriptomics-based analysis showed an increase in the expression of genes related to the immune response (including receptors, cytokines, and adhesion molecules), as well as to aerobic glycolysis. Further in vitro analyses showed that IL-6 production in response to C. albicans is controlled by MyD88- and SYK-pathways, suggesting an involvement of Toll-like and C-type lectin receptors and the subsequent activation of the MAP-kinases and c-Fos/AP-1 transcription factor. In addition, liver sinusoidal endothelial cells undergo metabolic reprogramming towards aerobic glycolysis induced by C. albicans, as confirmed by the increased Extracellular Acidification Rate and the overexpression of enolase (Eno2), hexonikase (Hk2) and glucose transporter 1 (Slc2a1). In conclusion, these results indicate that the hepatic endothelium responds to C. albicans by increasing aerobic glycolysis and promoting an inflammatory environment.This research was funded by the Basque Government, grant numbers IT1362-19 and IT1657-22, and the Spanish Ministry of Science via FECYT, grant number PRECIPITA_PR251. L.M−S and M.A have received a predoctoral grant from the Basque Government and L.A-F from the University of the Basque Country (UPV/EHU).Elsevier202420242024info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/68769reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.sciencedirect.com/science/article/pii/S128645792400025Xinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/3.0/es/© 2024 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Atribución-NoComercial-SinDerivadas 3.0 Españaoai:addi.ehu.eus:10810/687692026-06-18T09:23:17Z
dc.title.none.fl_str_mv Candida albicans increases the aerobic glycolysis and activates MAPK–dependent inflammatory response of liver sinusoidal endothelial cells
title Candida albicans increases the aerobic glycolysis and activates MAPK–dependent inflammatory response of liver sinusoidal endothelial cells
spellingShingle Candida albicans increases the aerobic glycolysis and activates MAPK–dependent inflammatory response of liver sinusoidal endothelial cells
Aparicio Fernández, Leire
liver endothelium
Candida
inflammation
metabolism
immune response
aerobic glycolysis
title_short Candida albicans increases the aerobic glycolysis and activates MAPK–dependent inflammatory response of liver sinusoidal endothelial cells
title_full Candida albicans increases the aerobic glycolysis and activates MAPK–dependent inflammatory response of liver sinusoidal endothelial cells
title_fullStr Candida albicans increases the aerobic glycolysis and activates MAPK–dependent inflammatory response of liver sinusoidal endothelial cells
title_full_unstemmed Candida albicans increases the aerobic glycolysis and activates MAPK–dependent inflammatory response of liver sinusoidal endothelial cells
title_sort Candida albicans increases the aerobic glycolysis and activates MAPK–dependent inflammatory response of liver sinusoidal endothelial cells
dc.creator.none.fl_str_mv Aparicio Fernández, Leire
Antorán Díaz, Aitziber
Areitio Beramendi, Maialen
Rodríguez Ereñaga, Oier
Martín Souto, Leire
Buldain Garriz, Idoia
Márquez Clavijo, Joana
Benedicto García, Aitor
Arteta Ruiz, Beatriz
Pellón Rodríguez, Aize
Moyes, David L.
Rementeria Ruiz, Aitor Domingo
Ramírez García, Andoni
author Aparicio Fernández, Leire
author_facet Aparicio Fernández, Leire
Antorán Díaz, Aitziber
Areitio Beramendi, Maialen
Rodríguez Ereñaga, Oier
Martín Souto, Leire
Buldain Garriz, Idoia
Márquez Clavijo, Joana
Benedicto García, Aitor
Arteta Ruiz, Beatriz
Pellón Rodríguez, Aize
Moyes, David L.
Rementeria Ruiz, Aitor Domingo
Ramírez García, Andoni
author_role author
author2 Antorán Díaz, Aitziber
Areitio Beramendi, Maialen
Rodríguez Ereñaga, Oier
Martín Souto, Leire
Buldain Garriz, Idoia
Márquez Clavijo, Joana
Benedicto García, Aitor
Arteta Ruiz, Beatriz
Pellón Rodríguez, Aize
Moyes, David L.
Rementeria Ruiz, Aitor Domingo
Ramírez García, Andoni
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv liver endothelium
Candida
inflammation
metabolism
immune response
aerobic glycolysis
topic liver endothelium
Candida
inflammation
metabolism
immune response
aerobic glycolysis
description The liver, and more specifically, the liver sinusoidal endothelial cells, constitute the beginning of one of the most important responses for the elimination of hematogenously disseminated Candida albicans. Therefore, we aimed to study the mechanisms involved in the interaction between these cells and C. albicans. Transcriptomics-based analysis showed an increase in the expression of genes related to the immune response (including receptors, cytokines, and adhesion molecules), as well as to aerobic glycolysis. Further in vitro analyses showed that IL-6 production in response to C. albicans is controlled by MyD88- and SYK-pathways, suggesting an involvement of Toll-like and C-type lectin receptors and the subsequent activation of the MAP-kinases and c-Fos/AP-1 transcription factor. In addition, liver sinusoidal endothelial cells undergo metabolic reprogramming towards aerobic glycolysis induced by C. albicans, as confirmed by the increased Extracellular Acidification Rate and the overexpression of enolase (Eno2), hexonikase (Hk2) and glucose transporter 1 (Slc2a1). In conclusion, these results indicate that the hepatic endothelium responds to C. albicans by increasing aerobic glycolysis and promoting an inflammatory environment.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/68769
url http://hdl.handle.net/10810/68769
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S128645792400025X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Atribución-NoComercial-SinDerivadas 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Atribución-NoComercial-SinDerivadas 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405472404013056
score 15,812455

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