The expression of IL-17, in chronic spontaneous urticaria is linked to Semaphorin5A

Background: Patients with chronic spontaneous urticaria (CSU), an autoimmune disorder, show increased skin expression of IL-17A and can benefit from treatment with the anti-IL-17A biologic secukinumab. The mechanisms that drive IL-17A expression in CSU are currently unknown, but may involve Semaphor...

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Autores: Matanis, Lobna, Eiza, Nasren, Sabag, Adi, Bejar, Jacob, Giménez Arnau, Anna Maria, Maurer, Marcus, Vadasz, Zahava
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/48357
Acceso en línea:http://hdl.handle.net/10230/48357
http://dx.doi.org/10.3390/biom11030373
Access Level:acceso abierto
Palabra clave:IL-17
T cells
Chronic spontaneous urticaria
Mast cells
Semaphorin5A
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oai_identifier_str oai:repositori.upf.edu:10230/48357
network_acronym_str ES
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repository_id_str
spelling The expression of IL-17, in chronic spontaneous urticaria is linked to Semaphorin5AMatanis, LobnaEiza, NasrenSabag, AdiBejar, JacobGiménez Arnau, Anna MariaMaurer, MarcusVadasz, ZahavaIL-17T cellsChronic spontaneous urticariaMast cellsSemaphorin5ABackground: Patients with chronic spontaneous urticaria (CSU), an autoimmune disorder, show increased skin expression of IL-17A and can benefit from treatment with the anti-IL-17A biologic secukinumab. The mechanisms that drive IL-17A expression in CSU are currently unknown, but may involve Semaphorin5A (Sema5A). Objective: To explore the expression, role, and effects of Sema5A in CSU and its link to IL-17A. Material and Methods: We investigated patients with CSU and healthy controls for skin expression of expressing peripheral T cells. Results: Sema5A was highly expressed in the skin of CSU patients as compared to healthy control skin. Both CD4+ T cells and mast cells in CSU skin expressed Sema5A, and many of them expressed both Sema5A and IL-17A. Patients with CSU had significantly higher rates of IL-17A-expressing CD4+ T cells as compared to healthy controls. Incubation with Sema5A increased the rates of IL-17A-expressing CD4+ T cells in healthy controls to CSU levels. Conclusion: Sema5A may drive the expression and effects of IL-17A in CSU. Further studies in larger cohorts are needed to confirm the role of Sema5A in the pathogenesis of CSU and to explore its potential as a therapeutic target.MDPI202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/48357http://dx.doi.org/10.3390/biom11030373reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésBiomolecules. 2021;11(3):373© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/483572026-06-12T07:21:37Z
dc.title.none.fl_str_mv The expression of IL-17, in chronic spontaneous urticaria is linked to Semaphorin5A
title The expression of IL-17, in chronic spontaneous urticaria is linked to Semaphorin5A
spellingShingle The expression of IL-17, in chronic spontaneous urticaria is linked to Semaphorin5A
Matanis, Lobna
IL-17
T cells
Chronic spontaneous urticaria
Mast cells
Semaphorin5A
title_short The expression of IL-17, in chronic spontaneous urticaria is linked to Semaphorin5A
title_full The expression of IL-17, in chronic spontaneous urticaria is linked to Semaphorin5A
title_fullStr The expression of IL-17, in chronic spontaneous urticaria is linked to Semaphorin5A
title_full_unstemmed The expression of IL-17, in chronic spontaneous urticaria is linked to Semaphorin5A
title_sort The expression of IL-17, in chronic spontaneous urticaria is linked to Semaphorin5A
dc.creator.none.fl_str_mv Matanis, Lobna
Eiza, Nasren
Sabag, Adi
Bejar, Jacob
Giménez Arnau, Anna Maria
Maurer, Marcus
Vadasz, Zahava
author Matanis, Lobna
author_facet Matanis, Lobna
Eiza, Nasren
Sabag, Adi
Bejar, Jacob
Giménez Arnau, Anna Maria
Maurer, Marcus
Vadasz, Zahava
author_role author
author2 Eiza, Nasren
Sabag, Adi
Bejar, Jacob
Giménez Arnau, Anna Maria
Maurer, Marcus
Vadasz, Zahava
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv IL-17
T cells
Chronic spontaneous urticaria
Mast cells
Semaphorin5A
topic IL-17
T cells
Chronic spontaneous urticaria
Mast cells
Semaphorin5A
description Background: Patients with chronic spontaneous urticaria (CSU), an autoimmune disorder, show increased skin expression of IL-17A and can benefit from treatment with the anti-IL-17A biologic secukinumab. The mechanisms that drive IL-17A expression in CSU are currently unknown, but may involve Semaphorin5A (Sema5A). Objective: To explore the expression, role, and effects of Sema5A in CSU and its link to IL-17A. Material and Methods: We investigated patients with CSU and healthy controls for skin expression of expressing peripheral T cells. Results: Sema5A was highly expressed in the skin of CSU patients as compared to healthy control skin. Both CD4+ T cells and mast cells in CSU skin expressed Sema5A, and many of them expressed both Sema5A and IL-17A. Patients with CSU had significantly higher rates of IL-17A-expressing CD4+ T cells as compared to healthy controls. Incubation with Sema5A increased the rates of IL-17A-expressing CD4+ T cells in healthy controls to CSU levels. Conclusion: Sema5A may drive the expression and effects of IL-17A in CSU. Further studies in larger cohorts are needed to confirm the role of Sema5A in the pathogenesis of CSU and to explore its potential as a therapeutic target.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/48357
http://dx.doi.org/10.3390/biom11030373
url http://hdl.handle.net/10230/48357
http://dx.doi.org/10.3390/biom11030373
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biomolecules. 2021;11(3):373
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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