Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis

Polyploidy is an extended phenomenon in biology. However, its physiological significance and whether it defines specific cell behaviors is not well understood. Here we study its connection to macroautophagy/autophagy, using the larval respiratory system of Drosophila as a model. This system comprise...

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Detalles Bibliográficos
Autores: Pino-Jiménez, Beatriz, Giannios, Panagiotis, Casanova, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/351593
Acceso en línea:http://hdl.handle.net/10261/351593
Access Level:acceso abierto
Palabra clave:Apoptosis
Autophagy
Drosophila
Polyploidy
Progenitor
Trachea
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repository_id_str
spelling Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosisPino-Jiménez, BeatrizGiannios, PanagiotisCasanova, JordiApoptosisAutophagyDrosophilaPolyploidyProgenitorTracheaPolyploidy is an extended phenomenon in biology. However, its physiological significance and whether it defines specific cell behaviors is not well understood. Here we study its connection to macroautophagy/autophagy, using the larval respiratory system of Drosophila as a model. This system comprises cells with the same function yet with notably different ploidy status, namely diploid progenitors and their polyploid larval counterparts, the latter destined to die during metamorphosis. We identified an association between polyploidy and autophagy and found that higher endoreplication status correlates with elevated autophagy. Finally, we report that tissue histolysis in the trachea during Drosophila metamorphosis is mediated by autophagy, which triggers the apoptosis of polyploid cells.The work was supported by the Ministerio de Ciencia y Tecnologia from the Spanish Government and by the Generalitat de Catalunya.Peer reviewedTaylor & FrancisMinisterio de Ciencia y Tecnología (España)Generalitat de CatalunyaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/351593reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésPino-Jiménez, Beatriz; Giannios, Panagiotis; Casanova, Jordi; 2023; Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.23652283.v1https://doi.org/10.1080/15548627.2023.2231828Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3515932026-05-22T06:33:51Z
dc.title.none.fl_str_mv Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis
title Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis
spellingShingle Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis
Pino-Jiménez, Beatriz
Apoptosis
Autophagy
Drosophila
Polyploidy
Progenitor
Trachea
title_short Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis
title_full Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis
title_fullStr Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis
title_full_unstemmed Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis
title_sort Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis
dc.creator.none.fl_str_mv Pino-Jiménez, Beatriz
Giannios, Panagiotis
Casanova, Jordi
author Pino-Jiménez, Beatriz
author_facet Pino-Jiménez, Beatriz
Giannios, Panagiotis
Casanova, Jordi
author_role author
author2 Giannios, Panagiotis
Casanova, Jordi
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia y Tecnología (España)
Generalitat de Catalunya
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Apoptosis
Autophagy
Drosophila
Polyploidy
Progenitor
Trachea
topic Apoptosis
Autophagy
Drosophila
Polyploidy
Progenitor
Trachea
description Polyploidy is an extended phenomenon in biology. However, its physiological significance and whether it defines specific cell behaviors is not well understood. Here we study its connection to macroautophagy/autophagy, using the larval respiratory system of Drosophila as a model. This system comprises cells with the same function yet with notably different ploidy status, namely diploid progenitors and their polyploid larval counterparts, the latter destined to die during metamorphosis. We identified an association between polyploidy and autophagy and found that higher endoreplication status correlates with elevated autophagy. Finally, we report that tissue histolysis in the trachea during Drosophila metamorphosis is mediated by autophagy, which triggers the apoptosis of polyploid cells.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/351593
url http://hdl.handle.net/10261/351593
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Pino-Jiménez, Beatriz; Giannios, Panagiotis; Casanova, Jordi; 2023; Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.23652283.v1
https://doi.org/10.1080/15548627.2023.2231828
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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