Correlation between tear osmolarity and tear meniscus

Purpose. To examine the relationship between tear meniscus height (TMH) and subjective meniscus grading (subjective TM) with tear osmolarity. Methods. Tear osmolarity measurements (using TearLab) and digital images of the tear meniscus were obtained in 177 consecutive patients undergoing an eye exam...

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Detalles Bibliográficos
Autores: García Resúa, Carlos, Pena Verdeal, Hugo, Remeseiro, Beatriz, Giráldez Fernández, María Jesús, Yebra-Pimentel Vilar, Eva
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/16745
Acceso en línea:http://hdl.handle.net/10347/16745
Access Level:acceso abierto
Palabra clave:Tear meniscus
TearLab Osmometer
ImageJ Software
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spelling Correlation between tear osmolarity and tear meniscusGarcía Resúa, CarlosPena Verdeal, HugoRemeseiro, BeatrizGiráldez Fernández, María JesúsYebra-Pimentel Vilar, EvaTear meniscusTearLab OsmometerImageJ SoftwarePurpose. To examine the relationship between tear meniscus height (TMH) and subjective meniscus grading (subjective TM) with tear osmolarity. Methods. Tear osmolarity measurements (using TearLab) and digital images of the tear meniscus were obtained in 177 consecutive patients undergoing an eye examination at our optometry clinic (Universidad de Santiago de Compostela, Spain) who fulfilled the study's inclusion criteria. Participants were also administered the McMonnies and Ocular Surface Disease Index (OSDI) questionnaires for the detection of dry eye disease. The lower tear meniscus was videotaped by a digital camera attached to a slit lamp in its central portion without fluorescein instillation. After the study, a masked observer extracted an image from each video, and measured the TMH using open source software (NIH ImageJ). Subsequently, the masked observer subjectively graded the appearance of each meniscus. For statistical analysis, subjects were stratified by age and by dry eye symptoms as indicated by their scores in the two questionnaires. Results. In the whole study population, a significant relationship was observed between osmolarity and TMH (-0.41, p<0.001) and osmolarity and subjective TM (r = 0.35, p<0.001). A cluster analysis revealed similar correlations when subjects were stratified by age or dry eye symptoms, these correlations being more pronounced in older and more symptomatic individuals. Objective TMH measurements and subjective meniscus quality were also correlated (r=-0.75, p<0.001). Conclusions. Osmolarity and both objective TMH measurements and subjective interpretation of the meniscus showed high correlation, especially in older symptomatic subjects.Wolters KluwerUniversidade de Santiago de Compostela. Departamento de Física Aplicada20142014-07-0220142014-07-02journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10347/16745reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/167452026-06-15T12:47:27Z
dc.title.none.fl_str_mv Correlation between tear osmolarity and tear meniscus
title Correlation between tear osmolarity and tear meniscus
spellingShingle Correlation between tear osmolarity and tear meniscus
García Resúa, Carlos
Tear meniscus
TearLab Osmometer
ImageJ Software
title_short Correlation between tear osmolarity and tear meniscus
title_full Correlation between tear osmolarity and tear meniscus
title_fullStr Correlation between tear osmolarity and tear meniscus
title_full_unstemmed Correlation between tear osmolarity and tear meniscus
title_sort Correlation between tear osmolarity and tear meniscus
dc.creator.none.fl_str_mv García Resúa, Carlos
Pena Verdeal, Hugo
Remeseiro, Beatriz
Giráldez Fernández, María Jesús
Yebra-Pimentel Vilar, Eva
author García Resúa, Carlos
author_facet García Resúa, Carlos
Pena Verdeal, Hugo
Remeseiro, Beatriz
Giráldez Fernández, María Jesús
Yebra-Pimentel Vilar, Eva
author_role author
author2 Pena Verdeal, Hugo
Remeseiro, Beatriz
Giráldez Fernández, María Jesús
Yebra-Pimentel Vilar, Eva
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Física Aplicada
dc.subject.none.fl_str_mv Tear meniscus
TearLab Osmometer
ImageJ Software
topic Tear meniscus
TearLab Osmometer
ImageJ Software
description Purpose. To examine the relationship between tear meniscus height (TMH) and subjective meniscus grading (subjective TM) with tear osmolarity. Methods. Tear osmolarity measurements (using TearLab) and digital images of the tear meniscus were obtained in 177 consecutive patients undergoing an eye examination at our optometry clinic (Universidad de Santiago de Compostela, Spain) who fulfilled the study's inclusion criteria. Participants were also administered the McMonnies and Ocular Surface Disease Index (OSDI) questionnaires for the detection of dry eye disease. The lower tear meniscus was videotaped by a digital camera attached to a slit lamp in its central portion without fluorescein instillation. After the study, a masked observer extracted an image from each video, and measured the TMH using open source software (NIH ImageJ). Subsequently, the masked observer subjectively graded the appearance of each meniscus. For statistical analysis, subjects were stratified by age and by dry eye symptoms as indicated by their scores in the two questionnaires. Results. In the whole study population, a significant relationship was observed between osmolarity and TMH (-0.41, p<0.001) and osmolarity and subjective TM (r = 0.35, p<0.001). A cluster analysis revealed similar correlations when subjects were stratified by age or dry eye symptoms, these correlations being more pronounced in older and more symptomatic individuals. Objective TMH measurements and subjective meniscus quality were also correlated (r=-0.75, p<0.001). Conclusions. Osmolarity and both objective TMH measurements and subjective interpretation of the meniscus showed high correlation, especially in older symptomatic subjects.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-07-02
2014
2014-07-02
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/16745
url http://hdl.handle.net/10347/16745
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer
publisher.none.fl_str_mv Wolters Kluwer
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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