A Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent

Despite the potential of photodynamic therapy (PDT) in cancer treatment, the development of efficient and photostable photosensitizing molecules that operate at long wavelengths of light has become a major hurdle. Here, we report for the first time an Ir(III)-phthalocyanine conjugate (Ir-ZnPc) as a...

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Autores: Bonelli Blasco, Joaquin Daniel, Ortega-Forte, Enrique, Vigueras, Gloria, Follana-Berná, Jorge, Ashoo, Pezhman, Abad-Montero, Diego, Isidro, Neus, López-Corrales, Marta, Hernández, Adrián, Ortiz, Javier, Izquierdo García, Eduardo, Bosch, Manel, Rocas, Josep, Sastre-Santos, Ángela, Ruiz, José, Marchán Sancho, Vicente
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/222920
Acceso en línea:https://hdl.handle.net/2445/222920
Access Level:acceso abierto
Palabra clave:Oxigen
Càncer
Iridi
Oxygen
Cancer
Iridium
id ES_2f17575e5ba465ea7c3cf85fed10000d
oai_identifier_str oai:diposit.ub.edu:2445/222920
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network_name_str España
repository_id_str
spelling A Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer AgentBonelli Blasco, Joaquin DanielOrtega-Forte, EnriqueVigueras, GloriaFollana-Berná, JorgeAshoo, PezhmanAbad-Montero, DiegoIsidro, NeusLópez-Corrales, MartaHernández, AdriánOrtiz, JavierIzquierdo García, EduardoBosch, ManelRocas, JosepSastre-Santos, ÁngelaRuiz, JoséMarchán Sancho, VicenteOxigenCàncerIridiOxygenCancerIridiumDespite the potential of photodynamic therapy (PDT) in cancer treatment, the development of efficient and photostable photosensitizing molecules that operate at long wavelengths of light has become a major hurdle. Here, we report for the first time an Ir(III)-phthalocyanine conjugate (Ir-ZnPc) as a novel photosensitizer for high-efficiency synergistic PDT treatment that takes advantage of the longwavelength excitation and near infrared (NIR) emission of the phthalocyanine scaffold and the known photostability and high phototoxicity of cyclometalated Ir(III) complexes. In order to increase water solubility and cell membrane permeability, the conjugate and parent zinc phthalocyanine (ZnPc) were encapsulated in amphoteric redox-responsive polyurethane-polyurea hybrid nanocapsules (Ir-ZnPc-NCs and ZnPc-NCs, respectively). Photobiological evaluations revealed that the encapsulated Ir-ZnPc conjugate achieved high photocytotoxicity in both normoxic and hypoxic conditions under 630 nm light irradiation, which can be attributed to dual Type I and Type II reactive oxygen species (ROS) photogeneration. Interestingly, PDT treatments with Ir-ZnPc-NCs and ZnPc-NCs significantly inhibited the growth of three-dimensional (3D) multicellular tumor spheroids. Overall, the nanoencapsulation of Zn phthalocyanines conjugated to cyclometalated Ir(III) complexes provides a new strategy for obtaining photostable and biocompatible red-light-activated nano-PDT agents with efficient performance under challenging hypoxic environments, thus offering new therapeutic opportunities for cancer treatment.American Chemical Society2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/222920Articles publicats en revistes (Química Inorgànica i Orgànica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1021/acsami.4c05181ACS Applied Materials & Interfaces, 2024, vol. 16, p. 38916-38930https://doi.org/10.1021/acsami.4c05181cc-by (c) Bonelli Blasco, Joaquin Daniel, et al., 2024http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2229202026-05-27T06:46:51Z
dc.title.none.fl_str_mv A Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent
title A Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent
spellingShingle A Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent
Bonelli Blasco, Joaquin Daniel
Oxigen
Càncer
Iridi
Oxygen
Cancer
Iridium
title_short A Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent
title_full A Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent
title_fullStr A Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent
title_full_unstemmed A Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent
title_sort A Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent
dc.creator.none.fl_str_mv Bonelli Blasco, Joaquin Daniel
Ortega-Forte, Enrique
Vigueras, Gloria
Follana-Berná, Jorge
Ashoo, Pezhman
Abad-Montero, Diego
Isidro, Neus
López-Corrales, Marta
Hernández, Adrián
Ortiz, Javier
Izquierdo García, Eduardo
Bosch, Manel
Rocas, Josep
Sastre-Santos, Ángela
Ruiz, José
Marchán Sancho, Vicente
author Bonelli Blasco, Joaquin Daniel
author_facet Bonelli Blasco, Joaquin Daniel
Ortega-Forte, Enrique
Vigueras, Gloria
Follana-Berná, Jorge
Ashoo, Pezhman
Abad-Montero, Diego
Isidro, Neus
López-Corrales, Marta
Hernández, Adrián
Ortiz, Javier
Izquierdo García, Eduardo
Bosch, Manel
Rocas, Josep
Sastre-Santos, Ángela
Ruiz, José
Marchán Sancho, Vicente
author_role author
author2 Ortega-Forte, Enrique
Vigueras, Gloria
Follana-Berná, Jorge
Ashoo, Pezhman
Abad-Montero, Diego
Isidro, Neus
López-Corrales, Marta
Hernández, Adrián
Ortiz, Javier
Izquierdo García, Eduardo
Bosch, Manel
Rocas, Josep
Sastre-Santos, Ángela
Ruiz, José
Marchán Sancho, Vicente
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Oxigen
Càncer
Iridi
Oxygen
Cancer
Iridium
topic Oxigen
Càncer
Iridi
Oxygen
Cancer
Iridium
description Despite the potential of photodynamic therapy (PDT) in cancer treatment, the development of efficient and photostable photosensitizing molecules that operate at long wavelengths of light has become a major hurdle. Here, we report for the first time an Ir(III)-phthalocyanine conjugate (Ir-ZnPc) as a novel photosensitizer for high-efficiency synergistic PDT treatment that takes advantage of the longwavelength excitation and near infrared (NIR) emission of the phthalocyanine scaffold and the known photostability and high phototoxicity of cyclometalated Ir(III) complexes. In order to increase water solubility and cell membrane permeability, the conjugate and parent zinc phthalocyanine (ZnPc) were encapsulated in amphoteric redox-responsive polyurethane-polyurea hybrid nanocapsules (Ir-ZnPc-NCs and ZnPc-NCs, respectively). Photobiological evaluations revealed that the encapsulated Ir-ZnPc conjugate achieved high photocytotoxicity in both normoxic and hypoxic conditions under 630 nm light irradiation, which can be attributed to dual Type I and Type II reactive oxygen species (ROS) photogeneration. Interestingly, PDT treatments with Ir-ZnPc-NCs and ZnPc-NCs significantly inhibited the growth of three-dimensional (3D) multicellular tumor spheroids. Overall, the nanoencapsulation of Zn phthalocyanines conjugated to cyclometalated Ir(III) complexes provides a new strategy for obtaining photostable and biocompatible red-light-activated nano-PDT agents with efficient performance under challenging hypoxic environments, thus offering new therapeutic opportunities for cancer treatment.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/222920
url https://hdl.handle.net/2445/222920
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1021/acsami.4c05181
ACS Applied Materials & Interfaces, 2024, vol. 16, p. 38916-38930
https://doi.org/10.1021/acsami.4c05181
dc.rights.none.fl_str_mv cc-by (c) Bonelli Blasco, Joaquin Daniel, et al., 2024
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Bonelli Blasco, Joaquin Daniel, et al., 2024
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Química Inorgànica i Orgànica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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