Circadian functioning and quality of life in substance use disorder patients with and without comorbid major depressive disorder

Aim: Although a relationship between circadian disruption and development of several psychiatric disorders, such as major depressive disorder (MDD) and substance use disorder (SUD), has been observed, knowledge on this area is scarce yet. Therefore, this study aims to analyze the circadian functioni...

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Autores: Hashemzadeh, Iman, Marquez Arrico, Julia E., Hashemzadeh, Kosar, Navarro Humanes, José Francisco, Adan Puig, Ana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/184370
Acceso en línea:https://hdl.handle.net/2445/184370
Access Level:acceso abierto
Palabra clave:Ritmes circadiaris
Depressió psíquica
Abús de substàncies
Addictes
Qualitat de vida
Circadian rhythms
Mental depression
Substance abuse
Addicts
Quality of life
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spelling Circadian functioning and quality of life in substance use disorder patients with and without comorbid major depressive disorderHashemzadeh, ImanMarquez Arrico, Julia E.Hashemzadeh, KosarNavarro Humanes, José FranciscoAdan Puig, AnaRitmes circadiarisDepressió psíquicaAbús de substànciesAddictesQualitat de vidaCircadian rhythmsMental depressionSubstance abuseAddictsQuality of lifeAim: Although a relationship between circadian disruption and development of several psychiatric disorders, such as major depressive disorder (MDD) and substance use disorder (SUD), has been observed, knowledge on this area is scarce yet. Therefore, this study aims to analyze the circadian functioning and quality of life (QOL) in SUD patients with and without comorbid MDD, two highly prevalent clinical entities with difficult therapeutic management. Methods: One hundred sixty-three male patients under treatment, 81 with SUD and 82 with SUD comorbid major depressive disorder (SUD + MDD), were evaluated. For the circadian functioning assessment, we calculated Social Jet Lag (SJL) and used the reduced Morningness-Eveningness Questionnaire (rMEQ) and the Pittsburgh Sleep Quality Index (PSQI). QOL was measured using the shortened version of the World Health Organization's Quality of Life Questionnaire (WHOQOL-BREF). We collected sociodemographic and clinical variables to evaluate their possible influence on the circadian functioning. Intergroup differences among the variables were examined by different analyses of covariance (ANCOVA and MANCOVA). The possible relationships of quantitative clinical variables with rMEQ, PSQI, and WHOQOL-BREF were explored using bivariate correlation analysis. Results: Lower SJL appears in the SUD + MDD group compared with SUD. The intermediate-type was more prevalent in the SUD group, while a higher percentage of morning-type patients was found in the SUD + MDD. Sleep quality (including latency and daytime dysfunction) was worse for SUD + MDD patients than for SUD even after controlling age and age of SUD onset variables. Last, QOL was poorer in patients with SUD + MDD and, for them, psychological health had a negative relationship with SJL and severity of depression. Conclusions: Our data support and extend previous findings indicating that SUD + MDD is associated with worse clinical characteristics, more sleep problems, and poorer QOL than SUD patients. These results underline the importance of a precise assessment of these measurements in future studies conducted in SUD patients with/without MDD comorbidity that could be considered from a therapeutic point of view.Frontiers Media2022202220212022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/184370Articles publicats en revistes (Psicologia Clínica i Psicobiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fpsyt.2021.750500Frontiers In Psychiatry, 2021, vol. 12, p. 750500https://doi.org/10.3389/fpsyt.2021.750500cc-by (c) Hashemzadeh, Iman et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1843702026-05-29T05:05:01Z
dc.title.none.fl_str_mv Circadian functioning and quality of life in substance use disorder patients with and without comorbid major depressive disorder
title Circadian functioning and quality of life in substance use disorder patients with and without comorbid major depressive disorder
spellingShingle Circadian functioning and quality of life in substance use disorder patients with and without comorbid major depressive disorder
Hashemzadeh, Iman
Ritmes circadiaris
Depressió psíquica
Abús de substàncies
Addictes
Qualitat de vida
Circadian rhythms
Mental depression
Substance abuse
Addicts
Quality of life
title_short Circadian functioning and quality of life in substance use disorder patients with and without comorbid major depressive disorder
title_full Circadian functioning and quality of life in substance use disorder patients with and without comorbid major depressive disorder
title_fullStr Circadian functioning and quality of life in substance use disorder patients with and without comorbid major depressive disorder
title_full_unstemmed Circadian functioning and quality of life in substance use disorder patients with and without comorbid major depressive disorder
title_sort Circadian functioning and quality of life in substance use disorder patients with and without comorbid major depressive disorder
dc.creator.none.fl_str_mv Hashemzadeh, Iman
Marquez Arrico, Julia E.
Hashemzadeh, Kosar
Navarro Humanes, José Francisco
Adan Puig, Ana
author Hashemzadeh, Iman
author_facet Hashemzadeh, Iman
Marquez Arrico, Julia E.
Hashemzadeh, Kosar
Navarro Humanes, José Francisco
Adan Puig, Ana
author_role author
author2 Marquez Arrico, Julia E.
Hashemzadeh, Kosar
Navarro Humanes, José Francisco
Adan Puig, Ana
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ritmes circadiaris
Depressió psíquica
Abús de substàncies
Addictes
Qualitat de vida
Circadian rhythms
Mental depression
Substance abuse
Addicts
Quality of life
topic Ritmes circadiaris
Depressió psíquica
Abús de substàncies
Addictes
Qualitat de vida
Circadian rhythms
Mental depression
Substance abuse
Addicts
Quality of life
description Aim: Although a relationship between circadian disruption and development of several psychiatric disorders, such as major depressive disorder (MDD) and substance use disorder (SUD), has been observed, knowledge on this area is scarce yet. Therefore, this study aims to analyze the circadian functioning and quality of life (QOL) in SUD patients with and without comorbid MDD, two highly prevalent clinical entities with difficult therapeutic management. Methods: One hundred sixty-three male patients under treatment, 81 with SUD and 82 with SUD comorbid major depressive disorder (SUD + MDD), were evaluated. For the circadian functioning assessment, we calculated Social Jet Lag (SJL) and used the reduced Morningness-Eveningness Questionnaire (rMEQ) and the Pittsburgh Sleep Quality Index (PSQI). QOL was measured using the shortened version of the World Health Organization's Quality of Life Questionnaire (WHOQOL-BREF). We collected sociodemographic and clinical variables to evaluate their possible influence on the circadian functioning. Intergroup differences among the variables were examined by different analyses of covariance (ANCOVA and MANCOVA). The possible relationships of quantitative clinical variables with rMEQ, PSQI, and WHOQOL-BREF were explored using bivariate correlation analysis. Results: Lower SJL appears in the SUD + MDD group compared with SUD. The intermediate-type was more prevalent in the SUD group, while a higher percentage of morning-type patients was found in the SUD + MDD. Sleep quality (including latency and daytime dysfunction) was worse for SUD + MDD patients than for SUD even after controlling age and age of SUD onset variables. Last, QOL was poorer in patients with SUD + MDD and, for them, psychological health had a negative relationship with SJL and severity of depression. Conclusions: Our data support and extend previous findings indicating that SUD + MDD is associated with worse clinical characteristics, more sleep problems, and poorer QOL than SUD patients. These results underline the importance of a precise assessment of these measurements in future studies conducted in SUD patients with/without MDD comorbidity that could be considered from a therapeutic point of view.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/184370
url https://hdl.handle.net/2445/184370
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fpsyt.2021.750500
Frontiers In Psychiatry, 2021, vol. 12, p. 750500
https://doi.org/10.3389/fpsyt.2021.750500
dc.rights.none.fl_str_mv cc-by (c) Hashemzadeh, Iman et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Hashemzadeh, Iman et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Psicologia Clínica i Psicobiologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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