Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study

Genetic variation; Non-steroidal anti-inflammatory drugs; Upper gastrointestinal haemorrhage

Detalles Bibliográficos
Autores: Mallah, Narmeen, Zapata‑Cachafeiro, Maruxa, Aguirre, Carmelo, Ibarra‑García, Eguzkiñe, Palacios-Zabalza, Itziar, Macías García, Fernando, Vidal Guitart, Xavier, Vendrell Bosch, Lourdes, Ibáñez, Luisa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/8802
Acceso en línea:https://hdl.handle.net/11351/8802
http://hdl.handle.net/11351/8802
Access Level:acceso abierto
Palabra clave:Hemorràgia gastrointestinal
Antiinflamatoris no esteroïdals - Efectes secundaris
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hemorrhage::Gastrointestinal Hemorrhage
Other subheadings::Other subheadings::Other subheadings::/chemically induced
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Peripheral Nervous System Agents::Sensory System Agents::Analgesics::Analgesics, Non-Narcotic::Anti-Inflammatory Agents, Non-Steroidal
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::hemorragia::hemorragia gastrointestinal
Otros calificadores::Otros calificadores::Otros calificadores::/inducido químicamente
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::fármacos del sistema nervioso periférico::fármacos del sistema sensitivo::analgésicos::analgésicos no narcóticos::antiinflamatorios no esteroideos
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
id ES_2f030c2dbfa73cc9bcd386e0d8ca2125
oai_identifier_str oai:recercat.cat:11351/8802
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study
title Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study
spellingShingle Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study
Mallah, Narmeen
Hemorràgia gastrointestinal
Antiinflamatoris no esteroïdals - Efectes secundaris
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hemorrhage::Gastrointestinal Hemorrhage
Other subheadings::Other subheadings::Other subheadings::/chemically induced
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Peripheral Nervous System Agents::Sensory System Agents::Analgesics::Analgesics, Non-Narcotic::Anti-Inflammatory Agents, Non-Steroidal
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::hemorragia::hemorragia gastrointestinal
Otros calificadores::Otros calificadores::Otros calificadores::/inducido químicamente
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::fármacos del sistema nervioso periférico::fármacos del sistema sensitivo::analgésicos::analgésicos no narcóticos::antiinflamatorios no esteroideos
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
title_short Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study
title_full Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study
title_fullStr Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study
title_full_unstemmed Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study
title_sort Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study
dc.creator.none.fl_str_mv Mallah, Narmeen
Zapata‑Cachafeiro, Maruxa
Aguirre, Carmelo
Ibarra‑García, Eguzkiñe
Palacios-Zabalza, Itziar
Macías García, Fernando
Vidal Guitart, Xavier
Vendrell Bosch, Lourdes
Ibáñez, Luisa
author Mallah, Narmeen
author_facet Mallah, Narmeen
Zapata‑Cachafeiro, Maruxa
Aguirre, Carmelo
Ibarra‑García, Eguzkiñe
Palacios-Zabalza, Itziar
Macías García, Fernando
Vidal Guitart, Xavier
Vendrell Bosch, Lourdes
Ibáñez, Luisa
author_role author
author2 Zapata‑Cachafeiro, Maruxa
Aguirre, Carmelo
Ibarra‑García, Eguzkiñe
Palacios-Zabalza, Itziar
Macías García, Fernando
Vidal Guitart, Xavier
Vendrell Bosch, Lourdes
Ibáñez, Luisa
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Mallah N] Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Spain. Genetics, Vaccines and Pediatric Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBER-ES), Carlos III Health Institute, Madrid, Spain. [Zapata-Cachafeiro M] Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Carlos III Health Institute, Madrid, Spain. [Aguirre C] Pharmacotherapy Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain. Basque Country Pharmacovigilance Unit, University Hospital of Galdakao-Usansolo, Osakidetza, Spain. Pharmacology Department, Medicine and Nursing Faculty, University of the Basque Country, Barakaldo, Spain. [Ibarra-García E] Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. Pharmacotherapy Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain. Osakidetza Basque Health Service, Pharmacy Department, Urduliz Hospital, Urduliz, Spain. [Palacios-Zabalza I] Pharmacotherapy Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain. Basque Country Pharmacovigilance Unit, University Hospital of Galdakao-Usansolo, Osakidetza, Spain. [Macías-García F] Department of Gastroenterology and Hepatology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain. [Ibáñez L, Vidal X, Vendrell L] Catalonian Institute of Pharmacology, Barcelona, Spain. Servei de Farmacologia Clínica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Departament de Farmacologia, de Terapèutica i de Toxicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Hemorràgia gastrointestinal
Antiinflamatoris no esteroïdals - Efectes secundaris
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hemorrhage::Gastrointestinal Hemorrhage
Other subheadings::Other subheadings::Other subheadings::/chemically induced
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Peripheral Nervous System Agents::Sensory System Agents::Analgesics::Analgesics, Non-Narcotic::Anti-Inflammatory Agents, Non-Steroidal
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::hemorragia::hemorragia gastrointestinal
Otros calificadores::Otros calificadores::Otros calificadores::/inducido químicamente
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::fármacos del sistema nervioso periférico::fármacos del sistema sensitivo::analgésicos::analgésicos no narcóticos::antiinflamatorios no esteroideos
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
topic Hemorràgia gastrointestinal
Antiinflamatoris no esteroïdals - Efectes secundaris
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hemorrhage::Gastrointestinal Hemorrhage
Other subheadings::Other subheadings::Other subheadings::/chemically induced
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Peripheral Nervous System Agents::Sensory System Agents::Analgesics::Analgesics, Non-Narcotic::Anti-Inflammatory Agents, Non-Steroidal
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::hemorragia::hemorragia gastrointestinal
Otros calificadores::Otros calificadores::Otros calificadores::/inducido químicamente
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::fármacos del sistema nervioso periférico::fármacos del sistema sensitivo::analgésicos::analgésicos no narcóticos::antiinflamatorios no esteroideos
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
description Genetic variation; Non-steroidal anti-inflammatory drugs; Upper gastrointestinal haemorrhage
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/8802
http://hdl.handle.net/11351/8802
url https://hdl.handle.net/11351/8802
http://hdl.handle.net/11351/8802
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Annals of Medicine;54(1)
https://doi.org/10.1080/07853890.2021.2016940
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control studyMallah, NarmeenZapata‑Cachafeiro, MaruxaAguirre, CarmeloIbarra‑García, EguzkiñePalacios-Zabalza, ItziarMacías García, FernandoVidal Guitart, XavierVendrell Bosch, LourdesIbáñez, LuisaHemorràgia gastrointestinalAntiinflamatoris no esteroïdals - Efectes secundarisDISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hemorrhage::Gastrointestinal HemorrhageOther subheadings::Other subheadings::Other subheadings::/chemically inducedCHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Peripheral Nervous System Agents::Sensory System Agents::Analgesics::Analgesics, Non-Narcotic::Anti-Inflammatory Agents, Non-SteroidalOther subheadings::Other subheadings::Other subheadings::/adverse effectsENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::hemorragia::hemorragia gastrointestinalOtros calificadores::Otros calificadores::Otros calificadores::/inducido químicamenteCOMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::fármacos del sistema nervioso periférico::fármacos del sistema sensitivo::analgésicos::analgésicos no narcóticos::antiinflamatorios no esteroideosOtros calificadores::Otros calificadores::Otros calificadores::/efectos adversosGenetic variation; Non-steroidal anti-inflammatory drugs; Upper gastrointestinal haemorrhageVariació genètica; Fàrmacs antiinflamatoris no esteroides; Hemorràgia gastrointestinal superiorVariación genética; Medicamentos antiinflamatorios no esteroideos; Hemorragia gastrointestinal superiorBackground Interindividual genetic variations contribute to differences in patients’ response to drugs as well as to the development of certain disorders. Patients who use non-steroidal anti-inflammatory drugs (NSAIDs) may develop serious gastrointestinal disorders, mainly upper gastrointestinal haemorrhage (UGIH). Studies about the interaction between NSAIDs and genetic variations on the risk of UGIH are scarce. Therefore, we investigated the effect of 16 single nucleotide polymorphisms (SNPs) involved in drug metabolism on the risk of NSAIDs-induced UGIH. Materials and methods We conducted a multicenter case-control study of 326 cases and 748 controls. Participants were sub-grouped into four categories according to NSAID exposure and genetic profile. We estimated odds ratios (ORs) and their 95% confidence intervals (CI) using generalized linear mixed models for dependent binomial variables and then calculated the measures of interaction, synergism index (S), and relative excess risk due to interaction (RERI). We undertook stratified analyses by the type of NSAID (aspirin, non-aspirin). Results We observed an excess risk of UGIH due to an interaction between any NSAID, non-aspirin NSAIDs or aspirin and carrying certain SNPs. The greatest excess risk was observed for carriers of: rs2180314:C>G [any NSAID: S = 3.30 (95%CI: 1.24–8.80), RERI = 4.39 (95%CI: 0.70–8.07); non-aspirin NSAIDs: S = 3.42 (95%CI: 1.12–10.47), RERI = 3.97 (95%CI: 0.44–7.50)], and rs4809957:A>G [any NSAID: S = 2.11 (95%CI: 0.90–4.97), RERI = 3.46 (95%CI: −0.40–7.31)]. Aspirin use by carriers of rs6664:C>T is also associated with increased risk of UGIH [ORaspirin(+),wild-type: 2.22 (95%CI: 0.69–7.17) vs. ORaspirin(+),genetic-variation: 7.72 (95%CI: 2.75–21.68)], yet larger sample size is needed to confirm this observation. Conclusions The joint effect of the SNPs s2180314:C>G and rs4809957:A>G and NSAIDs are more than three times higher than the sum of their individual effects. Personalized prescriptions based on genotyping would permit a better weighing of risks and benefits from NSAID consumption.This study was supported by grants from: Carlos III Health Institute (P I12/02414, of the P E I+D+I 2012-2016); Fondo Europeo de Desarrollo Regional (FEDER); the Novartis, Pfizer and Dr Esteve pharmaceutical companies; the Health Research Fund/Fondo de Investigaciońn Sanitaria (P I021512, P I021364, P I020661, and P I021572); Ministry of Health & Consumer Affairs, Spain (SAF2002-04057); Galician Regional Authority, Spain (P GIDIT03P XIC20806P N); Department of Health of the Basque Country (03/11092 and 11/111103); Fundacion Vasca de innovacion e investigacion sanitarias (OSIBG19/002 and OSIBG18/105). The genotyping service was carried out at CEGEN-P RB3-ISCIII; Carlos III Health Institute and ERDF (P T17/0019, of the P E I+D+I 2013-2016). The funding sources do not have any role in the study design; data collection, analysis and interpretation; writing the manuscript; and in the decision to submit the article for publication.Taylor & FrancisInstitut Català de la Salut[Mallah N] Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Spain. Genetics, Vaccines and Pediatric Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBER-ES), Carlos III Health Institute, Madrid, Spain. [Zapata-Cachafeiro M] Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Carlos III Health Institute, Madrid, Spain. [Aguirre C] Pharmacotherapy Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain. Basque Country Pharmacovigilance Unit, University Hospital of Galdakao-Usansolo, Osakidetza, Spain. Pharmacology Department, Medicine and Nursing Faculty, University of the Basque Country, Barakaldo, Spain. [Ibarra-García E] Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. Pharmacotherapy Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain. Osakidetza Basque Health Service, Pharmacy Department, Urduliz Hospital, Urduliz, Spain. [Palacios-Zabalza I] Pharmacotherapy Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain. Basque Country Pharmacovigilance Unit, University Hospital of Galdakao-Usansolo, Osakidetza, Spain. [Macías-García F] Department of Gastroenterology and Hepatology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain. [Ibáñez L, Vidal X, Vendrell L] Catalonian Institute of Pharmacology, Barcelona, Spain. Servei de Farmacologia Clínica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Departament de Farmacologia, de Terapèutica i de Toxicologia, Universitat Autònoma de Barcelona, Bellaterra, SpainVall d'Hebron Barcelona Hospital Campus202320232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8802http://hdl.handle.net/11351/8802Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAnnals of Medicine;54(1)https://doi.org/10.1080/07853890.2021.2016940Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/88022026-05-29T05:05:01Z
score 15,811543

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