Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death

Objective To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management. Design Nested case-control study within the EuroSIDA cohort. Methods Cases were subjects with AIDS or who died from any cause, with a pla...

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Detalles Bibliográficos
Autores: Casadellà, Maria, Cozzi-Lepri, Alessandro, Phillips, Andrew, Noguera-Julian, Marc, Bickel, Markus, Sedlacek, Dalibor, Zilmer, Kai, Clotet, Bonaventura, Lundgren, Jens D., Paredes, Roger
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:UVic-UCC
Repositorio:RiUVic. Repositori institucional de la UVic-UCC
OAI Identifier:oai:dspace.uvic.cat:10854/4927
Acceso en línea:http://hdl.handle.net/10854/4927
https://doi.org/10.1371/journal.pone.0166613
Access Level:acceso abierto
Palabra clave:Sida -- Tractament
VIH (Virus)
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oai_identifier_str oai:dspace.uvic.cat:10854/4927
network_acronym_str ES
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repository_id_str
spelling Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or DeathCasadellà, MariaCozzi-Lepri, AlessandroPhillips, AndrewNoguera-Julian, MarcBickel, MarkusSedlacek, DaliborZilmer, KaiClotet, BonaventuraLundgren, Jens D.Paredes, RogerSida -- TractamentVIH (Virus)Objective To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management. Design Nested case-control study within the EuroSIDA cohort. Methods Cases were subjects with AIDS or who died from any cause, with a plasma sample with HIV-1 RNA >1000 copies/mL available for tropism testing 3 to 12 months prior to the event. At least 1 control matched for age, HIV-1 RNA and HCV status at the time of sampling were selected per each case. Conditional logistic regression was used to investigate exposures associated with clinical progression to AIDS or death. A linear mixed model with random intercept was used to compare CD4+T-cell slopes by HIV tropism over the 12 months following the date of sampling. Results The study included 266 subjects, 100 cases and 166 controls; one quarter had X4 HIV; 26% were ART-naïve. Baseline factors independently associated with clinical progression or death were female gender (OR = 2.13 vs. male, 95CI = 1.04, 4.36), p = 0.038), CD4+T-cell count (OR = 0.90 (95CI = 0.80, 1.00) per 100 cells/mm3 higher, p = 0.058), being on ART (OR = 2.72 vs. being off-ART (95CI = 1.15, 6.41), p = 0.022) and calendar year of sample [OR = 0.84 (95CI = 0.77, 0.91) per more recent year, p<0.001). Baseline tropism was not associated with the risk of clinical progression or death. CD4+T-cell slopes did not differ within or between tropism groups.Plos OneUniversitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades2017201720172017info:eu-repo/semantics/articleinfo:eu-repo/publishedVersionapplication/pdf14 p.application/pdfhttp://hdl.handle.net/10854/4927https://doi.org/10.1371/journal.pone.0166613reponame:RiUVic. Repositori institucional de la UVic-UCCinstname:UVic-UCCInglésAquest document està subjecte a aquesta llicència Creative Commonshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dspace.uvic.cat:10854/49272026-06-07T19:15:21Z
dc.title.none.fl_str_mv Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death
title Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death
spellingShingle Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death
Casadellà, Maria
Sida -- Tractament
VIH (Virus)
title_short Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death
title_full Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death
title_fullStr Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death
title_full_unstemmed Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death
title_sort Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death
dc.creator.none.fl_str_mv Casadellà, Maria
Cozzi-Lepri, Alessandro
Phillips, Andrew
Noguera-Julian, Marc
Bickel, Markus
Sedlacek, Dalibor
Zilmer, Kai
Clotet, Bonaventura
Lundgren, Jens D.
Paredes, Roger
author Casadellà, Maria
author_facet Casadellà, Maria
Cozzi-Lepri, Alessandro
Phillips, Andrew
Noguera-Julian, Marc
Bickel, Markus
Sedlacek, Dalibor
Zilmer, Kai
Clotet, Bonaventura
Lundgren, Jens D.
Paredes, Roger
author_role author
author2 Cozzi-Lepri, Alessandro
Phillips, Andrew
Noguera-Julian, Marc
Bickel, Markus
Sedlacek, Dalibor
Zilmer, Kai
Clotet, Bonaventura
Lundgren, Jens D.
Paredes, Roger
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades
dc.subject.none.fl_str_mv Sida -- Tractament
VIH (Virus)
topic Sida -- Tractament
VIH (Virus)
description Objective To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management. Design Nested case-control study within the EuroSIDA cohort. Methods Cases were subjects with AIDS or who died from any cause, with a plasma sample with HIV-1 RNA >1000 copies/mL available for tropism testing 3 to 12 months prior to the event. At least 1 control matched for age, HIV-1 RNA and HCV status at the time of sampling were selected per each case. Conditional logistic regression was used to investigate exposures associated with clinical progression to AIDS or death. A linear mixed model with random intercept was used to compare CD4+T-cell slopes by HIV tropism over the 12 months following the date of sampling. Results The study included 266 subjects, 100 cases and 166 controls; one quarter had X4 HIV; 26% were ART-naïve. Baseline factors independently associated with clinical progression or death were female gender (OR = 2.13 vs. male, 95CI = 1.04, 4.36), p = 0.038), CD4+T-cell count (OR = 0.90 (95CI = 0.80, 1.00) per 100 cells/mm3 higher, p = 0.058), being on ART (OR = 2.72 vs. being off-ART (95CI = 1.15, 6.41), p = 0.022) and calendar year of sample [OR = 0.84 (95CI = 0.77, 0.91) per more recent year, p<0.001). Baseline tropism was not associated with the risk of clinical progression or death. CD4+T-cell slopes did not differ within or between tropism groups.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/publishedVersion
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10854/4927
https://doi.org/10.1371/journal.pone.0166613
url http://hdl.handle.net/10854/4927
https://doi.org/10.1371/journal.pone.0166613
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Aquest document està subjecte a aquesta llicència Creative Commons
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Aquest document està subjecte a aquesta llicència Creative Commons
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
14 p.
application/pdf
dc.publisher.none.fl_str_mv Plos One
publisher.none.fl_str_mv Plos One
dc.source.none.fl_str_mv reponame:RiUVic. Repositori institucional de la UVic-UCC
instname:UVic-UCC
instname_str UVic-UCC
reponame_str RiUVic. Repositori institucional de la UVic-UCC
collection RiUVic. Repositori institucional de la UVic-UCC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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