The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis

To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcomes in people at clinical high risk (CHR) for psychosis. 265 CHR individuals and 92 healthy controls were recruited as part of a prospective multi-center study. After a baseline asses...

Descripción completa

Detalles Bibliográficos
Autores: Tognin, Stefania|||0000-0002-1983-9135, Richter, Anja|||0000-0002-0253-6111, Kempton, Matthew|||0000-0003-3541-9947, Modinos, Gemma|||0000-0002-7870-066X, Antoniades, Mathilde, Azis, Matilda|||0000-0001-8164-0357, Allen, Paul, Bossong, Matthijs G., Perez, Jesus, Pantelis, Christos|||0000-0002-9565-0238, Nelson, Barnaby|||0000-0002-6263-2332, Amminger, G. Paul|||0000-0001-8969-4595, Riecher-Rössler, Anita|||0000-0001-6361-8789, Barrantes Vidal, Neus|||0000-0002-8671-1238, Krebs, Marie Odile|||0000-0002-4715-9890, Glenthøj, Birte|||0000-0003-3056-7262, Ruhrmann, Stephan|||0000-0002-6022-2364, Sachs, Gabriele|||0000-0002-8359-9877, Rutten, Bart P. F.|||0000-0002-9834-6346, Haan, Lieuwe de, 1960-|||0000-0002-3820-7926, Gaag, Mark van der, 1953-|||0000-0002-3525-6415, Valmaggia, Lucia|||0000-0001-6099-8464, McGuire, Philip|||0000-0003-4381-0532
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:280558
Acceso en línea:https://ddd.uab.cat/record/280558
https://dx.doi.org/urn:doi:10.1093/schizbullopen/sgac040
Access Level:acceso abierto
Palabra clave:Clinical high risk for psychosis
Clinical outcomes
Functioning
Remission
Transition to psychosis
Grey matter volume
Structural magnetic resonance imaging
Descripción
Sumario:To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcomes in people at clinical high risk (CHR) for psychosis. 265 CHR individuals and 92 healthy controls were recruited as part of a prospective multi-center study. After a baseline assessment using magnetic resonance imaging (MRI), participants were followed for at least two years to determine clinical and functional outcomes, including transition to psychosis (according to the Comprehensive Assessment of an At Risk Mental State, CAARMS), level of functioning (according to the Global Assessment of Functioning), and symptomatic remission (according to the CAARMS). GMV was measured in selected cortical and subcortical regions of interest (ROI) based on previous studies (ie orbitofrontal gyrus, cingulate gyrus, gyrus rectus, inferior temporal gyrus, parahippocampal gyrus, striatum, and hippocampus). Using voxel-based morphometry, we analysed the relationship between GMV and clinical and functional outcomes. Within the CHR sample, a poor functional outcome (GAF < 65) was associated with relatively lower GMV in the right striatum at baseline (P <.047 after Family Wise Error correction). There were no significant associations between baseline GMV and either subsequent remission or transition to psychosis. In CHR individuals, lower striatal GMV was associated with a poor level of overall functioning at follow-up. This finding was not related to effects of antipsychotic or antidepressant medication. The failure to replicate previous associations between GMV and later psychosis onset, despite studying a relatively large sample, is consistent with the findings of recent large-scale multi-center studies.

Similares en LA Referencia