Coenzyme Q(10) Therapy

Garrido-Maraver, Juan; Cordero, Mario D.; Oropesa-Ávila, Manuel; Fernández Vega, Alejandro; Mata, Mario de la; Delgado Pavón, Ana; Miguel Rodríguez, Manuel de; Sánchez-Alcázar, José Antonio

Coenzyme Q(10) Therapy

For a number of years, coenzyme Q 10 (CoQ 10 ) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in blood plasma, and extensively investigated its antioxidant role. These 2 functions constitute the basis for supporti...

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Autores:	Garrido-Maraver, Juan, Cordero, Mario D., Oropesa-Ávila, Manuel, Fernández Vega, Alejandro, Mata, Mario de la, Delgado Pavón, Ana, Miguel Rodríguez, Manuel de, Sánchez-Alcázar, José Antonio
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2014
País:	España
Institución:	Universidad de Sevilla (US)
Repositorio:	idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:	oai:idus.us.es:11441/142548
Acceso en línea:	https://hdl.handle.net/11441/142548 https://doi.org/10.1159/000360101
Access Level:	acceso abierto
Palabra clave:	Clinical indications Coenzyme Q 10 Coenzyme Q 10 -related compounds Pharmacokinetics

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spelling	Coenzyme Q(10) TherapyGarrido-Maraver, JuanCordero, Mario D.Oropesa-Ávila, ManuelFernández Vega, AlejandroMata, Mario de laDelgado Pavón, AnaMiguel Rodríguez, Manuel deSánchez-Alcázar, José AntonioClinical indicationsCoenzyme Q 10Coenzyme Q 10 -related compoundsPharmacokineticsFor a number of years, coenzyme Q 10 (CoQ 10 ) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in blood plasma, and extensively investigated its antioxidant role. These 2 functions constitute the basis for supporting the clinical use of CoQ 10 . Also, at the inner mitochondrial membrane level, CoQ 10 is recognized as an obligatory cofactor for the function of uncoupling proteins and a modulator of the mitochondrial transition pore. Furthermore, recent data indicate that CoQ 10 affects the expression of genes involved in human cell signaling, metabolism and transport, and some of the effects of CoQ 10 supplementation may be due to this property. CoQ 10 deficiencies are due to autosomal recessive mutations, mitochondrial diseases, aging-related oxidative stress and carcinogenesis processes, and also statin treatment. Many neurodegenerative disorders, diabetes, cancer, and muscular and cardiovascular diseases have been associated with low CoQ 10 levels as well as different ataxias and encephalomyopathies. CoQ 10 treatment does not cause serious adverse effects in humans and new formuhave been developed that increase CoQ 10 absorption and tissue distribution. Oral administration of CoQ 10 is a frequent antioxidant strategy in many diseases that may provide a significant symptomatic benefit.KARGERCitología e Histología Normal y PatológicaMinisterio de Sanidad. EspañaServicio Andaluz de Salud. Junta de Andalucía2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/142548https://doi.org/10.1159/000360101reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésMolecular Syndromology, 5 (3-4), 187-197.FIS PI10/00543FIS EC08/00076SAS 111242https://www.karger.com/Article/FullText/360101info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1425482026-06-17T12:51:07Z
dc.title.none.fl_str_mv	Coenzyme Q(10) Therapy
title	Coenzyme Q(10) Therapy
spellingShingle	Coenzyme Q(10) Therapy Garrido-Maraver, Juan Clinical indications Coenzyme Q 10 Coenzyme Q 10 -related compounds Pharmacokinetics
title_short	Coenzyme Q(10) Therapy
title_full	Coenzyme Q(10) Therapy
title_fullStr	Coenzyme Q(10) Therapy
title_full_unstemmed	Coenzyme Q(10) Therapy
title_sort	Coenzyme Q(10) Therapy
dc.creator.none.fl_str_mv	Garrido-Maraver, Juan Cordero, Mario D. Oropesa-Ávila, Manuel Fernández Vega, Alejandro Mata, Mario de la Delgado Pavón, Ana Miguel Rodríguez, Manuel de Sánchez-Alcázar, José Antonio
author	Garrido-Maraver, Juan
author_facet	Garrido-Maraver, Juan Cordero, Mario D. Oropesa-Ávila, Manuel Fernández Vega, Alejandro Mata, Mario de la Delgado Pavón, Ana Miguel Rodríguez, Manuel de Sánchez-Alcázar, José Antonio
author_role	author
author2	Cordero, Mario D. Oropesa-Ávila, Manuel Fernández Vega, Alejandro Mata, Mario de la Delgado Pavón, Ana Miguel Rodríguez, Manuel de Sánchez-Alcázar, José Antonio
author2_role	author author author author author author author
dc.contributor.none.fl_str_mv	Citología e Histología Normal y Patológica Ministerio de Sanidad. España Servicio Andaluz de Salud. Junta de Andalucía
dc.subject.none.fl_str_mv	Clinical indications Coenzyme Q 10 Coenzyme Q 10 -related compounds Pharmacokinetics
topic	Clinical indications Coenzyme Q 10 Coenzyme Q 10 -related compounds Pharmacokinetics
description	For a number of years, coenzyme Q 10 (CoQ 10 ) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in blood plasma, and extensively investigated its antioxidant role. These 2 functions constitute the basis for supporting the clinical use of CoQ 10 . Also, at the inner mitochondrial membrane level, CoQ 10 is recognized as an obligatory cofactor for the function of uncoupling proteins and a modulator of the mitochondrial transition pore. Furthermore, recent data indicate that CoQ 10 affects the expression of genes involved in human cell signaling, metabolism and transport, and some of the effects of CoQ 10 supplementation may be due to this property. CoQ 10 deficiencies are due to autosomal recessive mutations, mitochondrial diseases, aging-related oxidative stress and carcinogenesis processes, and also statin treatment. Many neurodegenerative disorders, diabetes, cancer, and muscular and cardiovascular diseases have been associated with low CoQ 10 levels as well as different ataxias and encephalomyopathies. CoQ 10 treatment does not cause serious adverse effects in humans and new formuhave been developed that increase CoQ 10 absorption and tissue distribution. Oral administration of CoQ 10 is a frequent antioxidant strategy in many diseases that may provide a significant symptomatic benefit.
publishDate	2014
dc.date.none.fl_str_mv	2014
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/11441/142548 https://doi.org/10.1159/000360101
url	https://hdl.handle.net/11441/142548 https://doi.org/10.1159/000360101
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Molecular Syndromology, 5 (3-4), 187-197. FIS PI10/00543 FIS EC08/00076 SAS 111242 https://www.karger.com/Article/FullText/360101
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	KARGER
publisher.none.fl_str_mv	KARGER
dc.source.none.fl_str_mv	reponame:idUS. Depósito de Investigación de la Universidad de Sevilla instname:Universidad de Sevilla (US)
instname_str	Universidad de Sevilla (US)
reponame_str	idUS. Depósito de Investigación de la Universidad de Sevilla
collection	idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
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Coenzyme Q(10) Therapy

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