Differential Expression of Galectin-1 and Galectin-9 in Immune-Mediated Inflammatory Diseases

Galectin-1 and -9 (Gal1/9) are essential mediators of immune-inflammatory responses, which makes these proteins potential biomarkers for immune-mediated diseases (IMIDs), such as rheumatoid arthritis (RA), psoriasis (PS), psoriatic arthritis (PsA), inflammatory bowel disease, and systemic lupus eryt...

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Autores: Valero-Martinez, C, Pardines-Ortiz, M, Montes, N, Dauden, E, Fernández-Gutierrez, B, Garcia-Planella, E, Garcia, FG, Gratacós, J, Perez-Venegas, JJ, Julia, A, Marsal, S, Lamana, A, Garcia-Vicuña, R, González-Alvaro, I, Triguero-Martinez, A
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p20172
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20172
Access Level:acceso abierto
Palavra-chave:immune-mediated inflammatory diseases
Galectin-1
Galectin-9
biomarkers
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spelling Differential Expression of Galectin-1 and Galectin-9 in Immune-Mediated Inflammatory DiseasesValero-Martinez, CPardines-Ortiz, MMontes, NDauden, EFernández-Gutierrez, BGarcia-Planella, EGarcia, FGGratacós, JPerez-Venegas, JJJulia, AMarsal, SLamana, AGarcia-Vicuña, RGonzález-Alvaro, ITriguero-Martinez, Aimmune-mediated inflammatory diseasesGalectin-1Galectin-9biomarkersGalectin-1 and -9 (Gal1/9) are essential mediators of immune-inflammatory responses, which makes these proteins potential biomarkers for immune-mediated diseases (IMIDs), such as rheumatoid arthritis (RA), psoriasis (PS), psoriatic arthritis (PsA), inflammatory bowel disease, and systemic lupus erythematosus (SLE). Our aim was to evaluate plasma Gal1/9 differences between IMID patients and healthy donors (HD). We analyzed 980 plasma samples divided into two analytical cohorts (600 discovery group and 380 validation group). Generalized linear models estimated Gal1/9 levels, adjusting for sex, age, storage time, and plate variability. In the overall IMID group, plasma Gal1 levels were comparable to those of HD, while Gal9 levels were significantly elevated. Levels varied across individual diseases: SLE patients consistently showed the highest Gal1/9 levels compared to both HD and other IMIDs, and RA patients had elevated Gal9 levels versus HD. Both Gal1 and Gal9 plasma levels correlated positively with higher disease activity, and Gal1 was higher in patients with longer disease duration. After adjustment for these confounders, SLE and RA patients maintained the highest Gal9 levels compared to HD. Our study demonstrates that Gal1 and Gal9 are differentially expressed across IMIDs, with particularly elevated levels in SLE, and both galectins are associated with disease activity.MDPI2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20172INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESISSN: 16616596ISSNe: 14220067reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p201722026-06-14T12:41:47Z
dc.title.none.fl_str_mv Differential Expression of Galectin-1 and Galectin-9 in Immune-Mediated Inflammatory Diseases
title Differential Expression of Galectin-1 and Galectin-9 in Immune-Mediated Inflammatory Diseases
spellingShingle Differential Expression of Galectin-1 and Galectin-9 in Immune-Mediated Inflammatory Diseases
Valero-Martinez, C
immune-mediated inflammatory diseases
Galectin-1
Galectin-9
biomarkers
title_short Differential Expression of Galectin-1 and Galectin-9 in Immune-Mediated Inflammatory Diseases
title_full Differential Expression of Galectin-1 and Galectin-9 in Immune-Mediated Inflammatory Diseases
title_fullStr Differential Expression of Galectin-1 and Galectin-9 in Immune-Mediated Inflammatory Diseases
title_full_unstemmed Differential Expression of Galectin-1 and Galectin-9 in Immune-Mediated Inflammatory Diseases
title_sort Differential Expression of Galectin-1 and Galectin-9 in Immune-Mediated Inflammatory Diseases
dc.creator.none.fl_str_mv Valero-Martinez, C
Pardines-Ortiz, M
Montes, N
Dauden, E
Fernández-Gutierrez, B
Garcia-Planella, E
Garcia, FG
Gratacós, J
Perez-Venegas, JJ
Julia, A
Marsal, S
Lamana, A
Garcia-Vicuña, R
González-Alvaro, I
Triguero-Martinez, A
author Valero-Martinez, C
author_facet Valero-Martinez, C
Pardines-Ortiz, M
Montes, N
Dauden, E
Fernández-Gutierrez, B
Garcia-Planella, E
Garcia, FG
Gratacós, J
Perez-Venegas, JJ
Julia, A
Marsal, S
Lamana, A
Garcia-Vicuña, R
González-Alvaro, I
Triguero-Martinez, A
author_role author
author2 Pardines-Ortiz, M
Montes, N
Dauden, E
Fernández-Gutierrez, B
Garcia-Planella, E
Garcia, FG
Gratacós, J
Perez-Venegas, JJ
Julia, A
Marsal, S
Lamana, A
Garcia-Vicuña, R
González-Alvaro, I
Triguero-Martinez, A
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv immune-mediated inflammatory diseases
Galectin-1
Galectin-9
biomarkers
topic immune-mediated inflammatory diseases
Galectin-1
Galectin-9
biomarkers
description Galectin-1 and -9 (Gal1/9) are essential mediators of immune-inflammatory responses, which makes these proteins potential biomarkers for immune-mediated diseases (IMIDs), such as rheumatoid arthritis (RA), psoriasis (PS), psoriatic arthritis (PsA), inflammatory bowel disease, and systemic lupus erythematosus (SLE). Our aim was to evaluate plasma Gal1/9 differences between IMID patients and healthy donors (HD). We analyzed 980 plasma samples divided into two analytical cohorts (600 discovery group and 380 validation group). Generalized linear models estimated Gal1/9 levels, adjusting for sex, age, storage time, and plate variability. In the overall IMID group, plasma Gal1 levels were comparable to those of HD, while Gal9 levels were significantly elevated. Levels varied across individual diseases: SLE patients consistently showed the highest Gal1/9 levels compared to both HD and other IMIDs, and RA patients had elevated Gal9 levels versus HD. Both Gal1 and Gal9 plasma levels correlated positively with higher disease activity, and Gal1 was higher in patients with longer disease duration. After adjustment for these confounders, SLE and RA patients maintained the highest Gal9 levels compared to HD. Our study demonstrates that Gal1 and Gal9 are differentially expressed across IMIDs, with particularly elevated levels in SLE, and both galectins are associated with disease activity.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20172
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20172
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN: 16616596
ISSNe: 14220067
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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