Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica

Approximately 3 million people in the world die every year as a consequence of COPD, a pathological process with a high impact also in Chile. COPD is associated with an abnormal inflammatory response of the lung to noxious particles and gases. This inflammatory pattern causes histopathological chang...

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Detalhes bibliográficos
Autores: Silva O., Rafael, Montes Castillo, Juan Francisco, Garcia Valero, Josep, Olloquequi, Jordi
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/176542
Acesso em linha:https://hdl.handle.net/2445/176542
Access Level:acceso abierto
Palavra-chave:Malalties pulmonars obstructives cròniques
Chronic obstructive pulmonary diseases
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spelling Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónicaSilva O., RafaelMontes Castillo, Juan FranciscoGarcia Valero, JosepOlloquequi, JordiMalalties pulmonars obstructives cròniquesChronic obstructive pulmonary diseasesApproximately 3 million people in the world die every year as a consequence of COPD, a pathological process with a high impact also in Chile. COPD is associated with an abnormal inflammatory response of the lung to noxious particles and gases. This inflammatory pattern causes histopathological changes that lead to a narrowing of small airways lumen and destruction of lung parenchyma, also known as emphysema. Classically, these changes were associated to macrophages and neutrophils, although T CD8+ lymphocytes were latter added to the equation, in order to explain the origin of emphysematous lesions. However, in recent years, multiple evidences have arisen indicating that inflammatory response in COPD is much more complex. These findings point to a key role for mast cells, dendritic cells, T CD4+ cells and B cells. The aim of this article is to review such evidence and present what is known so far about the protagonist cells of the inflammatory response in COPD.Sociedad Médica de Santiago2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/176542Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaEspañolReproducció del document publicat a: https://doi.org/10.4067/S0034-98872015000900009Revista Medica de Chile, 2015, vol. 143, p. 1162-1171https://doi.org/10.4067/S0034-98872015000900009cc-by (c) Silva O., Rafael et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1765422026-05-27T06:46:51Z
dc.title.none.fl_str_mv Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
title Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
spellingShingle Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
Silva O., Rafael
Malalties pulmonars obstructives cròniques
Chronic obstructive pulmonary diseases
title_short Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
title_full Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
title_fullStr Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
title_full_unstemmed Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
title_sort Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
dc.creator.none.fl_str_mv Silva O., Rafael
Montes Castillo, Juan Francisco
Garcia Valero, Josep
Olloquequi, Jordi
author Silva O., Rafael
author_facet Silva O., Rafael
Montes Castillo, Juan Francisco
Garcia Valero, Josep
Olloquequi, Jordi
author_role author
author2 Montes Castillo, Juan Francisco
Garcia Valero, Josep
Olloquequi, Jordi
author2_role author
author
author
dc.subject.none.fl_str_mv Malalties pulmonars obstructives cròniques
Chronic obstructive pulmonary diseases
topic Malalties pulmonars obstructives cròniques
Chronic obstructive pulmonary diseases
description Approximately 3 million people in the world die every year as a consequence of COPD, a pathological process with a high impact also in Chile. COPD is associated with an abnormal inflammatory response of the lung to noxious particles and gases. This inflammatory pattern causes histopathological changes that lead to a narrowing of small airways lumen and destruction of lung parenchyma, also known as emphysema. Classically, these changes were associated to macrophages and neutrophils, although T CD8+ lymphocytes were latter added to the equation, in order to explain the origin of emphysematous lesions. However, in recent years, multiple evidences have arisen indicating that inflammatory response in COPD is much more complex. These findings point to a key role for mast cells, dendritic cells, T CD4+ cells and B cells. The aim of this article is to review such evidence and present what is known so far about the protagonist cells of the inflammatory response in COPD.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/176542
url https://hdl.handle.net/2445/176542
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.4067/S0034-98872015000900009
Revista Medica de Chile, 2015, vol. 143, p. 1162-1171
https://doi.org/10.4067/S0034-98872015000900009
dc.rights.none.fl_str_mv cc-by (c) Silva O., Rafael et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Silva O., Rafael et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedad Médica de Santiago
publisher.none.fl_str_mv Sociedad Médica de Santiago
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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