Early-life and health behaviour influences on lung function in early adulthood

Early-life exposures may influence lung function at different stages of the life course. However, the relative importance of characteristics at different stages of infancy and childhood are unclear. To examine the associations and relative importance of early-life events on lung function at age 24 y...

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Autores: Mahmoud, Osama, Granell, Raquel, Peralta, Gabriela P., García Aymerich, Judith, Jarvis, Deborah, Henderson, John, Sterne, Jonathan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/57210
Acceso en línea:http://hdl.handle.net/10230/57210
http://dx.doi.org/10.1183/13993003.01316-2020
Access Level:acceso abierto
Palabra clave:Pulmons
Aparell respiratori
Pulmons -- Malalties
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spelling Early-life and health behaviour influences on lung function in early adulthoodMahmoud, OsamaGranell, RaquelPeralta, Gabriela P.García Aymerich, JudithJarvis, DeborahHenderson, JohnSterne, JonathanPulmonsAparell respiratoriPulmons -- MalaltiesEarly-life exposures may influence lung function at different stages of the life course. However, the relative importance of characteristics at different stages of infancy and childhood are unclear. To examine the associations and relative importance of early-life events on lung function at age 24 years. We followed 7545 children from the Avon Longitudinal Study of Parents and Children from birth to 24 years. Using previous knowledge, we classified an extensive list of putative risk factors for low lung function, covering sociodemographic, environmental, lifestyle and physiological characteristics, according to timing of exposure: 1) demographic, maternal and child; 2) perinatal; 3) postnatal; 4) early childhood; and 5) adolescence characteristics. Lung function measurements (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC and forced expiratory flow at 25–75% of FVC) were standardised for sex, age and height. The proportion of the remaining variance explained by each characteristic was calculated. The association and relative importance (RI) of each characteristic for each lung function measure was estimated using linear regression, adjusted for other characteristics in the same and previous categories. Lower maternal perinatal body mass index (BMI), lower birthweight, lower lean mass and higher fat mass in childhood had the largest RI (0.5–7.7%) for decreased FVC. Having no siblings, lower birthweight, lower lean mass and higher fat mass were associated with decreased FEV1 (RI 0.5–4.6%). Higher lean mass and childhood asthma were associated with decreased FEV1/FVC (RI 0.6–0.8%). Maternal perinatal BMI, birthweight, childhood lean and fat mass and early-onset asthma are the factors in infancy and childhood that have the greatest influence on early-adult lung function.The present analyses are part of the ALEC (Ageing Lungs in European Cohorts) Study (www.alecstudy.org), which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement number 633212. The content of this article reflects only the authors’ views, and the European Commission is not liable for any use that may be made of the information contained therein. The UK Medical Research Council and Wellcome (grant 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and J. Sterne will serve as guarantor for the contents of this paper. Funding information for this article has been deposited with the Crossref Funder Registry.European Respiratory Society202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/57210http://dx.doi.org/10.1183/13993003.01316-2020reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEuropean Respiratory Journal. 2023 Mar 1;61(3):2001316info:eu-repo/grantAgreement/EC/H2020/633212© The authors 2023. This version is distributed under the terms of the Creative Commons Attribution Licence 4.0.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/572102026-05-29T05:05:01Z
dc.title.none.fl_str_mv Early-life and health behaviour influences on lung function in early adulthood
title Early-life and health behaviour influences on lung function in early adulthood
spellingShingle Early-life and health behaviour influences on lung function in early adulthood
Mahmoud, Osama
Pulmons
Aparell respiratori
Pulmons -- Malalties
title_short Early-life and health behaviour influences on lung function in early adulthood
title_full Early-life and health behaviour influences on lung function in early adulthood
title_fullStr Early-life and health behaviour influences on lung function in early adulthood
title_full_unstemmed Early-life and health behaviour influences on lung function in early adulthood
title_sort Early-life and health behaviour influences on lung function in early adulthood
dc.creator.none.fl_str_mv Mahmoud, Osama
Granell, Raquel
Peralta, Gabriela P.
García Aymerich, Judith
Jarvis, Deborah
Henderson, John
Sterne, Jonathan
author Mahmoud, Osama
author_facet Mahmoud, Osama
Granell, Raquel
Peralta, Gabriela P.
García Aymerich, Judith
Jarvis, Deborah
Henderson, John
Sterne, Jonathan
author_role author
author2 Granell, Raquel
Peralta, Gabriela P.
García Aymerich, Judith
Jarvis, Deborah
Henderson, John
Sterne, Jonathan
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Pulmons
Aparell respiratori
Pulmons -- Malalties
topic Pulmons
Aparell respiratori
Pulmons -- Malalties
description Early-life exposures may influence lung function at different stages of the life course. However, the relative importance of characteristics at different stages of infancy and childhood are unclear. To examine the associations and relative importance of early-life events on lung function at age 24 years. We followed 7545 children from the Avon Longitudinal Study of Parents and Children from birth to 24 years. Using previous knowledge, we classified an extensive list of putative risk factors for low lung function, covering sociodemographic, environmental, lifestyle and physiological characteristics, according to timing of exposure: 1) demographic, maternal and child; 2) perinatal; 3) postnatal; 4) early childhood; and 5) adolescence characteristics. Lung function measurements (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC and forced expiratory flow at 25–75% of FVC) were standardised for sex, age and height. The proportion of the remaining variance explained by each characteristic was calculated. The association and relative importance (RI) of each characteristic for each lung function measure was estimated using linear regression, adjusted for other characteristics in the same and previous categories. Lower maternal perinatal body mass index (BMI), lower birthweight, lower lean mass and higher fat mass in childhood had the largest RI (0.5–7.7%) for decreased FVC. Having no siblings, lower birthweight, lower lean mass and higher fat mass were associated with decreased FEV1 (RI 0.5–4.6%). Higher lean mass and childhood asthma were associated with decreased FEV1/FVC (RI 0.6–0.8%). Maternal perinatal BMI, birthweight, childhood lean and fat mass and early-onset asthma are the factors in infancy and childhood that have the greatest influence on early-adult lung function.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/57210
http://dx.doi.org/10.1183/13993003.01316-2020
url http://hdl.handle.net/10230/57210
http://dx.doi.org/10.1183/13993003.01316-2020
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv European Respiratory Journal. 2023 Mar 1;61(3):2001316
info:eu-repo/grantAgreement/EC/H2020/633212
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv European Respiratory Society
publisher.none.fl_str_mv European Respiratory Society
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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