Lymphatic Regeneration after Popliteal Lymph Node Excision and Implantation of Aligned Nanofibrillar Collagen Scaffolds

Lymphedema presents significant challenges to patients' quality of life, prompting the exploration of innovative treatments, such as collagen scaffolds, aimed at treating and reducing the risk of lymphedema. We aimed to evaluate the preventive and therapeutic efficacy and the lymphangiogenic po...

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Autores: Campos Sánchez, José Luis|||0000-0001-8077-2454, Pons, Gemma|||0000-0001-8803-5432, Al-Sakkaf, Ali Mahdi Al-Haddar|||0000-0002-8180-198X, Lusetti, Irene Laura|||0000-0002-2564-9610, Pires, L., Vela, F.J., Ramos, E., Crisóstomo, Verónica|||0000-0003-1740-7029, Masià, Jaume|||0000-0003-0141-9586, Sánchez Margallo, Francisco Miguel|||0000-0003-2138-988X, Abellán, Elena
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:324419
Acceso en línea:https://ddd.uab.cat/record/324419
https://dx.doi.org/urn:doi:10.3390/jfb15080235
Access Level:acceso abierto
Palabra clave:BioBridge
Lymphatic regeneration
Lymphedema
Microsurgery
Rabbit animal model
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spelling Lymphatic Regeneration after Popliteal Lymph Node Excision and Implantation of Aligned Nanofibrillar Collagen ScaffoldsAn Experimental Rabbit ModelCampos Sánchez, José Luis|||0000-0001-8077-2454Pons, Gemma|||0000-0001-8803-5432Al-Sakkaf, Ali Mahdi Al-Haddar|||0000-0002-8180-198XLusetti, Irene Laura|||0000-0002-2564-9610Pires, L.Vela, F.J.Ramos, E.Crisóstomo, Verónica|||0000-0003-1740-7029Masià, Jaume|||0000-0003-0141-9586Sánchez Margallo, Francisco Miguel|||0000-0003-2138-988XAbellán, ElenaBioBridgeLymphatic regenerationLymphedemaMicrosurgeryRabbit animal modelLymphedema presents significant challenges to patients' quality of life, prompting the exploration of innovative treatments, such as collagen scaffolds, aimed at treating and reducing the risk of lymphedema. We aimed to evaluate the preventive and therapeutic efficacy and the lymphangiogenic potential of implanted aligned nanofibrillar collagen scaffolds (BioBridge) following the induction of secondary lymphedema in a rabbit model. Thirty rabbits were divided into treatment (G1), prevention (G2), and control (G3) groups. Secondary lymphedema was induced in all groups. BioBridge implantation was performed in G2 and G1 on days 0 and 60, respectively. Follow-ups included hindlimb circumference measurements and indocyanine green lymphography at 0, 60, and 90 days. None of the study rabbits exhibited dermal backflow on day 0 before surgery. At 60 days, the incidence rates of dermal backflow in G1, G2, and G3 were 100%, 44.4%, and 90%, respectively. Furthermore, at 90 days, the incidence rates were 22.2%, 44.4%, and 90%, respectively. New linear lymphatic observation was seen in rabbits with resolved dermal backflow. The findings of this study demonstrated the capacity of BioBridge scaffolds to induce new lymphatic vessel formation and reduce dermal backflow in secondary lymphedema in a rabbit model.Universitat Autònoma de Barcelona. Departament de Medicina 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/324419https://dx.doi.org/urn:doi:10.3390/jfb15080235reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3244192026-06-06T12:50:31Z
dc.title.none.fl_str_mv Lymphatic Regeneration after Popliteal Lymph Node Excision and Implantation of Aligned Nanofibrillar Collagen Scaffolds
An Experimental Rabbit Model
title Lymphatic Regeneration after Popliteal Lymph Node Excision and Implantation of Aligned Nanofibrillar Collagen Scaffolds
spellingShingle Lymphatic Regeneration after Popliteal Lymph Node Excision and Implantation of Aligned Nanofibrillar Collagen Scaffolds
Campos Sánchez, José Luis|||0000-0001-8077-2454
BioBridge
Lymphatic regeneration
Lymphedema
Microsurgery
Rabbit animal model
title_short Lymphatic Regeneration after Popliteal Lymph Node Excision and Implantation of Aligned Nanofibrillar Collagen Scaffolds
title_full Lymphatic Regeneration after Popliteal Lymph Node Excision and Implantation of Aligned Nanofibrillar Collagen Scaffolds
title_fullStr Lymphatic Regeneration after Popliteal Lymph Node Excision and Implantation of Aligned Nanofibrillar Collagen Scaffolds
title_full_unstemmed Lymphatic Regeneration after Popliteal Lymph Node Excision and Implantation of Aligned Nanofibrillar Collagen Scaffolds
title_sort Lymphatic Regeneration after Popliteal Lymph Node Excision and Implantation of Aligned Nanofibrillar Collagen Scaffolds
dc.creator.none.fl_str_mv Campos Sánchez, José Luis|||0000-0001-8077-2454
Pons, Gemma|||0000-0001-8803-5432
Al-Sakkaf, Ali Mahdi Al-Haddar|||0000-0002-8180-198X
Lusetti, Irene Laura|||0000-0002-2564-9610
Pires, L.
Vela, F.J.
Ramos, E.
Crisóstomo, Verónica|||0000-0003-1740-7029
Masià, Jaume|||0000-0003-0141-9586
Sánchez Margallo, Francisco Miguel|||0000-0003-2138-988X
Abellán, Elena
author Campos Sánchez, José Luis|||0000-0001-8077-2454
author_facet Campos Sánchez, José Luis|||0000-0001-8077-2454
Pons, Gemma|||0000-0001-8803-5432
Al-Sakkaf, Ali Mahdi Al-Haddar|||0000-0002-8180-198X
Lusetti, Irene Laura|||0000-0002-2564-9610
Pires, L.
Vela, F.J.
Ramos, E.
Crisóstomo, Verónica|||0000-0003-1740-7029
Masià, Jaume|||0000-0003-0141-9586
Sánchez Margallo, Francisco Miguel|||0000-0003-2138-988X
Abellán, Elena
author_role author
author2 Pons, Gemma|||0000-0001-8803-5432
Al-Sakkaf, Ali Mahdi Al-Haddar|||0000-0002-8180-198X
Lusetti, Irene Laura|||0000-0002-2564-9610
Pires, L.
Vela, F.J.
Ramos, E.
Crisóstomo, Verónica|||0000-0003-1740-7029
Masià, Jaume|||0000-0003-0141-9586
Sánchez Margallo, Francisco Miguel|||0000-0003-2138-988X
Abellán, Elena
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Departament de Medicina
dc.subject.none.fl_str_mv BioBridge
Lymphatic regeneration
Lymphedema
Microsurgery
Rabbit animal model
topic BioBridge
Lymphatic regeneration
Lymphedema
Microsurgery
Rabbit animal model
description Lymphedema presents significant challenges to patients' quality of life, prompting the exploration of innovative treatments, such as collagen scaffolds, aimed at treating and reducing the risk of lymphedema. We aimed to evaluate the preventive and therapeutic efficacy and the lymphangiogenic potential of implanted aligned nanofibrillar collagen scaffolds (BioBridge) following the induction of secondary lymphedema in a rabbit model. Thirty rabbits were divided into treatment (G1), prevention (G2), and control (G3) groups. Secondary lymphedema was induced in all groups. BioBridge implantation was performed in G2 and G1 on days 0 and 60, respectively. Follow-ups included hindlimb circumference measurements and indocyanine green lymphography at 0, 60, and 90 days. None of the study rabbits exhibited dermal backflow on day 0 before surgery. At 60 days, the incidence rates of dermal backflow in G1, G2, and G3 were 100%, 44.4%, and 90%, respectively. Furthermore, at 90 days, the incidence rates were 22.2%, 44.4%, and 90%, respectively. New linear lymphatic observation was seen in rabbits with resolved dermal backflow. The findings of this study demonstrated the capacity of BioBridge scaffolds to induce new lymphatic vessel formation and reduce dermal backflow in secondary lymphedema in a rabbit model.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/324419
https://dx.doi.org/urn:doi:10.3390/jfb15080235
url https://ddd.uab.cat/record/324419
https://dx.doi.org/urn:doi:10.3390/jfb15080235
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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