Prediction of absolute risk of fragility fracture at 10 years in a Spanish population: validation of the WHO FRAX ™ tool in Spain

Background: Age-related bone loss is asymptomatic, and the morbidity of osteoporosis is secondary to the fractures that occur. Common sites of fracture include the spine, hip, forearm and proximal humerus. Fractures at the hip incur the greatest morbidity and mortality and give rise to the highest d...

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Autores: Azagra Ledesma, Rafael, Roca, Genís, Encabo, Gloria, Prieto, Daniel, Aguyé, Amada, Zwart, Marta, Güell, Sílvia, Puchol, Núria, Gene, Emili, Casado, Enrique, Sancho, Pilar, Solà, Silvia, Torán, Pere, Iglesias, Milagros, Sabaté, Victòria, López Expósito, Francesc, Ortiz Alinque, Sergio, Fernandez, Yolanda, Díez Pérez, Adolfo
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2011
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/126776
Acesso em linha:https://hdl.handle.net/2445/126776
Access Level:Acceso aberto
Palavra-chave:Densitometria òssia
Osteoporosi
Bone densitometry
Osteoporosis
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spelling Prediction of absolute risk of fragility fracture at 10 years in a Spanish population: validation of the WHO FRAX ™ tool in SpainAzagra Ledesma, RafaelRoca, GenísEncabo, GloriaPrieto, DanielAguyé, AmadaZwart, MartaGüell, SílviaPuchol, NúriaGene, EmiliCasado, EnriqueSancho, PilarSolà, SilviaTorán, PereIglesias, MilagrosSabaté, VictòriaLópez Expósito, FrancescOrtiz Alinque, SergioFernandez, YolandaDíez Pérez, AdolfoDensitometria òssiaOsteoporosiBone densitometryOsteoporosisBackground: Age-related bone loss is asymptomatic, and the morbidity of osteoporosis is secondary to the fractures that occur. Common sites of fracture include the spine, hip, forearm and proximal humerus. Fractures at the hip incur the greatest morbidity and mortality and give rise to the highest direct costs for health services. Their incidence increases exponentially with age. Independently changes in population demography, the age - and sex- specific incidence of osteoporotic fractures appears to be increasing in developing and developed countries. This could mean more than double the expected burden of osteoporotic fractures in the next 50 years. Methods/Design: To assess the predictive power of the WHO FRAX (TM) tool to identify the subjects with the highest absolute risk of fragility fracture at 10 years in a Spanish population, a predictive validation study of the tool will be carried out. For this purpose, the participants recruited by 1999 will be assessed. These were referred to scan-DXA Department from primary healthcare centres, non hospital and hospital consultations. Study population: Patients attended in the national health services integrated into a FRIDEX cohort with at least one Dual-energy X-ray absorptiometry (DXA) measurement and one extensive questionnaire related to fracture risk factors. Measurements: At baseline bone mineral density measurement using DXA, clinical fracture risk factors questionnaire, dietary calcium intake assessment, history of previous fractures, and related drugs. Follow up by telephone interview to know fragility fractures in the 10 years with verification in electronic medical records and also to know the number of falls in the last year. The absolute risk of fracture will be estimated using the FRAX (TM) tool from the official web site. Discussion: Since more than 10 years ago numerous publications have recognised the importance of other risk factors for new osteoporotic fractures in addition to low BMD. The extension of a method for calculating the risk (probability) of fractures using the FRAX (TM) tool is foreseeable in Spain and this would justify a study such as this to allow the necessary adjustments in calibration of the parameters included in the logarithmic formula constituted by FRAX (TM)BioMed Central2018201820112018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/126776Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/1471-2474-12-30BMC Musculoskeletal Disorders, 2011, vol. 12, num. 30https://doi.org/10.1186/1471-2474-12-30cc by (c) Azagra et al., 2011http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1267762026-05-29T05:05:01Z
dc.title.none.fl_str_mv Prediction of absolute risk of fragility fracture at 10 years in a Spanish population: validation of the WHO FRAX ™ tool in Spain
title Prediction of absolute risk of fragility fracture at 10 years in a Spanish population: validation of the WHO FRAX ™ tool in Spain
spellingShingle Prediction of absolute risk of fragility fracture at 10 years in a Spanish population: validation of the WHO FRAX ™ tool in Spain
Azagra Ledesma, Rafael
Densitometria òssia
Osteoporosi
Bone densitometry
Osteoporosis
title_short Prediction of absolute risk of fragility fracture at 10 years in a Spanish population: validation of the WHO FRAX ™ tool in Spain
title_full Prediction of absolute risk of fragility fracture at 10 years in a Spanish population: validation of the WHO FRAX ™ tool in Spain
title_fullStr Prediction of absolute risk of fragility fracture at 10 years in a Spanish population: validation of the WHO FRAX ™ tool in Spain
title_full_unstemmed Prediction of absolute risk of fragility fracture at 10 years in a Spanish population: validation of the WHO FRAX ™ tool in Spain
title_sort Prediction of absolute risk of fragility fracture at 10 years in a Spanish population: validation of the WHO FRAX ™ tool in Spain
dc.creator.none.fl_str_mv Azagra Ledesma, Rafael
Roca, Genís
Encabo, Gloria
Prieto, Daniel
Aguyé, Amada
Zwart, Marta
Güell, Sílvia
Puchol, Núria
Gene, Emili
Casado, Enrique
Sancho, Pilar
Solà, Silvia
Torán, Pere
Iglesias, Milagros
Sabaté, Victòria
López Expósito, Francesc
Ortiz Alinque, Sergio
Fernandez, Yolanda
Díez Pérez, Adolfo
author Azagra Ledesma, Rafael
author_facet Azagra Ledesma, Rafael
Roca, Genís
Encabo, Gloria
Prieto, Daniel
Aguyé, Amada
Zwart, Marta
Güell, Sílvia
Puchol, Núria
Gene, Emili
Casado, Enrique
Sancho, Pilar
Solà, Silvia
Torán, Pere
Iglesias, Milagros
Sabaté, Victòria
López Expósito, Francesc
Ortiz Alinque, Sergio
Fernandez, Yolanda
Díez Pérez, Adolfo
author_role author
author2 Roca, Genís
Encabo, Gloria
Prieto, Daniel
Aguyé, Amada
Zwart, Marta
Güell, Sílvia
Puchol, Núria
Gene, Emili
Casado, Enrique
Sancho, Pilar
Solà, Silvia
Torán, Pere
Iglesias, Milagros
Sabaté, Victòria
López Expósito, Francesc
Ortiz Alinque, Sergio
Fernandez, Yolanda
Díez Pérez, Adolfo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Densitometria òssia
Osteoporosi
Bone densitometry
Osteoporosis
topic Densitometria òssia
Osteoporosi
Bone densitometry
Osteoporosis
description Background: Age-related bone loss is asymptomatic, and the morbidity of osteoporosis is secondary to the fractures that occur. Common sites of fracture include the spine, hip, forearm and proximal humerus. Fractures at the hip incur the greatest morbidity and mortality and give rise to the highest direct costs for health services. Their incidence increases exponentially with age. Independently changes in population demography, the age - and sex- specific incidence of osteoporotic fractures appears to be increasing in developing and developed countries. This could mean more than double the expected burden of osteoporotic fractures in the next 50 years. Methods/Design: To assess the predictive power of the WHO FRAX (TM) tool to identify the subjects with the highest absolute risk of fragility fracture at 10 years in a Spanish population, a predictive validation study of the tool will be carried out. For this purpose, the participants recruited by 1999 will be assessed. These were referred to scan-DXA Department from primary healthcare centres, non hospital and hospital consultations. Study population: Patients attended in the national health services integrated into a FRIDEX cohort with at least one Dual-energy X-ray absorptiometry (DXA) measurement and one extensive questionnaire related to fracture risk factors. Measurements: At baseline bone mineral density measurement using DXA, clinical fracture risk factors questionnaire, dietary calcium intake assessment, history of previous fractures, and related drugs. Follow up by telephone interview to know fragility fractures in the 10 years with verification in electronic medical records and also to know the number of falls in the last year. The absolute risk of fracture will be estimated using the FRAX (TM) tool from the official web site. Discussion: Since more than 10 years ago numerous publications have recognised the importance of other risk factors for new osteoporotic fractures in addition to low BMD. The extension of a method for calculating the risk (probability) of fractures using the FRAX (TM) tool is foreseeable in Spain and this would justify a study such as this to allow the necessary adjustments in calibration of the parameters included in the logarithmic formula constituted by FRAX (TM)
publishDate 2011
dc.date.none.fl_str_mv 2011
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126776
url https://hdl.handle.net/2445/126776
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/1471-2474-12-30
BMC Musculoskeletal Disorders, 2011, vol. 12, num. 30
https://doi.org/10.1186/1471-2474-12-30
dc.rights.none.fl_str_mv cc by (c) Azagra et al., 2011
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Azagra et al., 2011
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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