miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β

As patient survival drops precipitously from early-stage cancers to late-stage and metastatic cancers, microRNAs that promote relapse and metastasis can serve as prognostic and predictive markers as well as therapeutic targets for chemoprevention. Here we show that miR-1269a promotes colorectal canc...

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Autores: Bu, Pengcheng, Wang, Lihua, Chen, Kai-Yuan, Rakhilin, Nikolai, Sun, Jian, Closa, Adrià, Tung, Kuei-Ling, King, Sarah, Kristine Varanko, Anastasia, Xu, Yitian, Huan Chen, Joyce, Zessin, Amelia S., Shealy, James, Cummings, Bethany, Hsu, David, Lipkin, Steven M., Moreno Aguado, Víctor, Gümüş, Zeynep H., Shen, Xiling
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/125584
Acceso en línea:https://hdl.handle.net/2445/125584
Access Level:acceso abierto
Palabra clave:Càncer
Quimioteràpia del càncer
Metàstasi
Cancer
Cancer chemotherapy
Metastasis
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spelling miR-1269 promotes metastasis and forms a positive feedback loop with TGF-βBu, PengchengWang, LihuaChen, Kai-YuanRakhilin, NikolaiSun, JianClosa, AdriàTung, Kuei-LingKing, SarahKristine Varanko, AnastasiaXu, YitianHuan Chen, JoyceZessin, Amelia S.Shealy, JamesCummings, BethanyHsu, DavidLipkin, Steven M.Moreno Aguado, VíctorGümüş, Zeynep H.Shen, XilingCàncerQuimioteràpia del càncerMetàstasiCancerCancer chemotherapyMetastasisAs patient survival drops precipitously from early-stage cancers to late-stage and metastatic cancers, microRNAs that promote relapse and metastasis can serve as prognostic and predictive markers as well as therapeutic targets for chemoprevention. Here we show that miR-1269a promotes colorectal cancer (CRC) metastasis and forms a positive feedback loop with TGF-β signalling. miR-1269a is upregulated in late-stage CRCs, and long-term monitoring of 100 stage II CRC patients revealed that miR-1269a expression in their surgically removed primary tumours is strongly associated with risk of CRC relapse and metastasis. Consistent with clinical observations, miR-1269a significantly increases the ability of CRC cells to invade and metastasize in vivo. TGF-β activates miR-1269 via Sox4, while miR-1269a enhances TGF-β signalling by targeting Smad7 and HOXD10, hence forming a positive feedback loop. Our findings suggest that miR-1269a is a potential marker to inform adjuvant chemotherapy decisions for CRC patients and a potential therapeutic target to deter metastasis.Nature Publishing Group2018201820152018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/125584Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/ncomms7879Nature Communications, 2015, vol. 15, num. 6, p. 6879https://doi.org/10.1038/ncomms7879cc-by (c) Bu, Pengcheng et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1255842026-05-29T05:05:01Z
dc.title.none.fl_str_mv miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β
title miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β
spellingShingle miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β
Bu, Pengcheng
Càncer
Quimioteràpia del càncer
Metàstasi
Cancer
Cancer chemotherapy
Metastasis
title_short miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β
title_full miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β
title_fullStr miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β
title_full_unstemmed miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β
title_sort miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β
dc.creator.none.fl_str_mv Bu, Pengcheng
Wang, Lihua
Chen, Kai-Yuan
Rakhilin, Nikolai
Sun, Jian
Closa, Adrià
Tung, Kuei-Ling
King, Sarah
Kristine Varanko, Anastasia
Xu, Yitian
Huan Chen, Joyce
Zessin, Amelia S.
Shealy, James
Cummings, Bethany
Hsu, David
Lipkin, Steven M.
Moreno Aguado, Víctor
Gümüş, Zeynep H.
Shen, Xiling
author Bu, Pengcheng
author_facet Bu, Pengcheng
Wang, Lihua
Chen, Kai-Yuan
Rakhilin, Nikolai
Sun, Jian
Closa, Adrià
Tung, Kuei-Ling
King, Sarah
Kristine Varanko, Anastasia
Xu, Yitian
Huan Chen, Joyce
Zessin, Amelia S.
Shealy, James
Cummings, Bethany
Hsu, David
Lipkin, Steven M.
Moreno Aguado, Víctor
Gümüş, Zeynep H.
Shen, Xiling
author_role author
author2 Wang, Lihua
Chen, Kai-Yuan
Rakhilin, Nikolai
Sun, Jian
Closa, Adrià
Tung, Kuei-Ling
King, Sarah
Kristine Varanko, Anastasia
Xu, Yitian
Huan Chen, Joyce
Zessin, Amelia S.
Shealy, James
Cummings, Bethany
Hsu, David
Lipkin, Steven M.
Moreno Aguado, Víctor
Gümüş, Zeynep H.
Shen, Xiling
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer
Quimioteràpia del càncer
Metàstasi
Cancer
Cancer chemotherapy
Metastasis
topic Càncer
Quimioteràpia del càncer
Metàstasi
Cancer
Cancer chemotherapy
Metastasis
description As patient survival drops precipitously from early-stage cancers to late-stage and metastatic cancers, microRNAs that promote relapse and metastasis can serve as prognostic and predictive markers as well as therapeutic targets for chemoprevention. Here we show that miR-1269a promotes colorectal cancer (CRC) metastasis and forms a positive feedback loop with TGF-β signalling. miR-1269a is upregulated in late-stage CRCs, and long-term monitoring of 100 stage II CRC patients revealed that miR-1269a expression in their surgically removed primary tumours is strongly associated with risk of CRC relapse and metastasis. Consistent with clinical observations, miR-1269a significantly increases the ability of CRC cells to invade and metastasize in vivo. TGF-β activates miR-1269 via Sox4, while miR-1269a enhances TGF-β signalling by targeting Smad7 and HOXD10, hence forming a positive feedback loop. Our findings suggest that miR-1269a is a potential marker to inform adjuvant chemotherapy decisions for CRC patients and a potential therapeutic target to deter metastasis.
publishDate 2015
dc.date.none.fl_str_mv 2015
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/125584
url https://hdl.handle.net/2445/125584
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/ncomms7879
Nature Communications, 2015, vol. 15, num. 6, p. 6879
https://doi.org/10.1038/ncomms7879
dc.rights.none.fl_str_mv cc-by (c) Bu, Pengcheng et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Bu, Pengcheng et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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