The age at onset of relapsing-remitting multiple sclerosis has increased over the last five decades

Background: Patients with relapsing-remitting multiple sclerosis (RRMS) most commonly experience their first symptoms between 20 and 40 years of age. The objective of this study was to investigate how the age at which the first symptoms of RRMS occur has changed over the past decades. Methods: Patie...

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Autores: Romero Pinel, Lucía María, Bau, Laura, Matas Martín, Elisabet, León, Isabel, Muñoz-Vendrell, Albert, Arroyo, Pablo, Masuet Aumatell, Cristina, Martínez Yélamos, Antonio, Martínez Yélamos, Sergio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/190239
Acceso en línea:https://hdl.handle.net/2445/190239
Access Level:acceso abierto
Palabra clave:Epidemiologia
Esclerosi múltiple
Símptomes
Epidemiology
Multiple sclerosis
Symptoms
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spelling The age at onset of relapsing-remitting multiple sclerosis has increased over the last five decadesRomero Pinel, Lucía MaríaBau, LauraMatas Martín, ElisabetLeón, IsabelMuñoz-Vendrell, AlbertArroyo, PabloMasuet Aumatell, CristinaMartínez Yélamos, AntonioMartínez Yélamos, SergioEpidemiologiaEsclerosi múltipleSímptomesEpidemiologyMultiple sclerosisSymptomsBackground: Patients with relapsing-remitting multiple sclerosis (RRMS) most commonly experience their first symptoms between 20 and 40 years of age. The objective of this study was to investigate how the age at which the first symptoms of RRMS occur has changed over the past decades. Methods: Patients who were followed up in our unit after an initial diagnosis of RRMS using the Poser or McDonald criteria and who experienced their first symptoms between January 1970 and December 2019 were included in the study. The cohort was divided into five groups according to the decade in which the first symptoms appeared. The age at disease onset was compared across decades. Changes in age were also determined after excluding patients with early-onset disease (<18 years of age) and those with late-onset disease (>50 years of age) to avoid bias. Results: The cohort included 1,622 patients with RRMS, 67.6% of whom were women. Among them, 5.9% and 4% had early-onset and late-onset disease, respectively. The mean age ± standard deviation at onset was 31.11 ± 9.82 years, with no differences between men and women. The mean ages at onset were 23.79 ± 10.19 years between 1970 and 1979, 27.86 ± 9.22 years between 1980 and 1989, 30.07 ± 9.32 years between 1990 and 1999, 32.12 ± 9.47 between 2000 and 2009, and 34.28 ± 9.83 years between 2010 and 2019. The ages at disease onset were progressively higher in the later decades; this trend was statistically significant (p < 0.001), with a Pearson linear correlation coefficient R of 0.264 and R2 of 0.070 (p < 0.001). The results were similar when analysing men and women separately. We conducted an analysis of 1,460 patients (mean age at onset: 31.10 ± 7.99 years), after excluding patients with early-onset and late-onset disease. In this specific subgroup, the mean ages at disease onset were 28.38 ± 8.17 years between 1970 and 1979, 29.22 ± 7.51 years between 1980 and 1989, 30.06 ± 8.02 years between 1990 and 1999, 31.46 ± 7.77 years between 2000 and 2009, and 33.37 ± 7.97 years between 2010 and 2019. The trend was also statistically significant (p < 0.001), with a Pearson linear correlation coefficient R of 0.193 and R2 of 0.037 (p < 0.001).Elsevier B.V.2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfhttps://hdl.handle.net/2445/190239Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.msard.2022.104103Multiple Sclerosis and Related Disorders, 2022, vol. 68, p. 104103https://doi.org/10.1016/j.msard.2022.104103cc-by-nc-nd (c) Romero Pinel, Lucía et al., 2022https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1902392026-05-29T05:05:01Z
dc.title.none.fl_str_mv The age at onset of relapsing-remitting multiple sclerosis has increased over the last five decades
title The age at onset of relapsing-remitting multiple sclerosis has increased over the last five decades
spellingShingle The age at onset of relapsing-remitting multiple sclerosis has increased over the last five decades
Romero Pinel, Lucía María
Epidemiologia
Esclerosi múltiple
Símptomes
Epidemiology
Multiple sclerosis
Symptoms
title_short The age at onset of relapsing-remitting multiple sclerosis has increased over the last five decades
title_full The age at onset of relapsing-remitting multiple sclerosis has increased over the last five decades
title_fullStr The age at onset of relapsing-remitting multiple sclerosis has increased over the last five decades
title_full_unstemmed The age at onset of relapsing-remitting multiple sclerosis has increased over the last five decades
title_sort The age at onset of relapsing-remitting multiple sclerosis has increased over the last five decades
dc.creator.none.fl_str_mv Romero Pinel, Lucía María
Bau, Laura
Matas Martín, Elisabet
León, Isabel
Muñoz-Vendrell, Albert
Arroyo, Pablo
Masuet Aumatell, Cristina
Martínez Yélamos, Antonio
Martínez Yélamos, Sergio
author Romero Pinel, Lucía María
author_facet Romero Pinel, Lucía María
Bau, Laura
Matas Martín, Elisabet
León, Isabel
Muñoz-Vendrell, Albert
Arroyo, Pablo
Masuet Aumatell, Cristina
Martínez Yélamos, Antonio
Martínez Yélamos, Sergio
author_role author
author2 Bau, Laura
Matas Martín, Elisabet
León, Isabel
Muñoz-Vendrell, Albert
Arroyo, Pablo
Masuet Aumatell, Cristina
Martínez Yélamos, Antonio
Martínez Yélamos, Sergio
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Epidemiologia
Esclerosi múltiple
Símptomes
Epidemiology
Multiple sclerosis
Symptoms
topic Epidemiologia
Esclerosi múltiple
Símptomes
Epidemiology
Multiple sclerosis
Symptoms
description Background: Patients with relapsing-remitting multiple sclerosis (RRMS) most commonly experience their first symptoms between 20 and 40 years of age. The objective of this study was to investigate how the age at which the first symptoms of RRMS occur has changed over the past decades. Methods: Patients who were followed up in our unit after an initial diagnosis of RRMS using the Poser or McDonald criteria and who experienced their first symptoms between January 1970 and December 2019 were included in the study. The cohort was divided into five groups according to the decade in which the first symptoms appeared. The age at disease onset was compared across decades. Changes in age were also determined after excluding patients with early-onset disease (<18 years of age) and those with late-onset disease (>50 years of age) to avoid bias. Results: The cohort included 1,622 patients with RRMS, 67.6% of whom were women. Among them, 5.9% and 4% had early-onset and late-onset disease, respectively. The mean age ± standard deviation at onset was 31.11 ± 9.82 years, with no differences between men and women. The mean ages at onset were 23.79 ± 10.19 years between 1970 and 1979, 27.86 ± 9.22 years between 1980 and 1989, 30.07 ± 9.32 years between 1990 and 1999, 32.12 ± 9.47 between 2000 and 2009, and 34.28 ± 9.83 years between 2010 and 2019. The ages at disease onset were progressively higher in the later decades; this trend was statistically significant (p < 0.001), with a Pearson linear correlation coefficient R of 0.264 and R2 of 0.070 (p < 0.001). The results were similar when analysing men and women separately. We conducted an analysis of 1,460 patients (mean age at onset: 31.10 ± 7.99 years), after excluding patients with early-onset and late-onset disease. In this specific subgroup, the mean ages at disease onset were 28.38 ± 8.17 years between 1970 and 1979, 29.22 ± 7.51 years between 1980 and 1989, 30.06 ± 8.02 years between 1990 and 1999, 31.46 ± 7.77 years between 2000 and 2009, and 33.37 ± 7.97 years between 2010 and 2019. The trend was also statistically significant (p < 0.001), with a Pearson linear correlation coefficient R of 0.193 and R2 of 0.037 (p < 0.001).
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/190239
url https://hdl.handle.net/2445/190239
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.msard.2022.104103
Multiple Sclerosis and Related Disorders, 2022, vol. 68, p. 104103
https://doi.org/10.1016/j.msard.2022.104103
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Romero Pinel, Lucía et al., 2022
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Romero Pinel, Lucía et al., 2022
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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