Fasciola hepatica juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanism

22 páginas, 8 figuras

Detalles Bibliográficos
Autores: Serrat, Judit, Becerro Recio, David, Torres Valle, María, Simón Marta, Fernando, Valero, María Adela, Bargues, María Dolores, Mas-Coma, Santiago, Siles Lucas, Mar, González Miguel, Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/311063
Acceso en línea:http://hdl.handle.net/10261/311063
https://api.elsevier.com/content/abstract/scopus_id/85159304682
Access Level:acceso abierto
Palabra clave:Fasciola hepatica
Host fibrinolytic system
Fascioliasis
Fibrinolysin
Host-Parasite Interactions
Mass Spectrometry
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oai_identifier_str oai:digital.csic.es:10261/311063
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Fasciola hepatica juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanism
title Fasciola hepatica juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanism
spellingShingle Fasciola hepatica juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanism
Serrat, Judit
Fasciola hepatica
Host fibrinolytic system
Fascioliasis
Fibrinolysin
Host-Parasite Interactions
Mass Spectrometry
title_short Fasciola hepatica juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanism
title_full Fasciola hepatica juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanism
title_fullStr Fasciola hepatica juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanism
title_full_unstemmed Fasciola hepatica juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanism
title_sort Fasciola hepatica juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanism
dc.creator.none.fl_str_mv Serrat, Judit
Becerro Recio, David
Torres Valle, María
Simón Marta, Fernando
Valero, María Adela
Bargues, María Dolores
Mas-Coma, Santiago
Siles Lucas, Mar
González Miguel, Javier
author Serrat, Judit
author_facet Serrat, Judit
Becerro Recio, David
Torres Valle, María
Simón Marta, Fernando
Valero, María Adela
Bargues, María Dolores
Mas-Coma, Santiago
Siles Lucas, Mar
González Miguel, Javier
author_role author
author2 Becerro Recio, David
Torres Valle, María
Simón Marta, Fernando
Valero, María Adela
Bargues, María Dolores
Mas-Coma, Santiago
Siles Lucas, Mar
González Miguel, Javier
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Junta de Castilla y León
Generalitat Valenciana
Ministerio de Ciencia e Innovación (España)
European Commission
Serrat, Judit [0000-0002-1182-1088]
Becerro Recio, David [0000-0001-8876-2592]
Torres Valle, María [0000-0003-0503-2688]
Siles Lucas, Mar [0000-0002-1257-2562]
González Miguel, Javier [0000-0003-4279-4761]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Fasciola hepatica
Host fibrinolytic system
Fascioliasis
Fibrinolysin
Host-Parasite Interactions
Mass Spectrometry
topic Fasciola hepatica
Host fibrinolytic system
Fascioliasis
Fibrinolysin
Host-Parasite Interactions
Mass Spectrometry
description 22 páginas, 8 figuras
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/311063
https://api.elsevier.com/content/abstract/scopus_id/85159304682
url http://hdl.handle.net/10261/311063
https://api.elsevier.com/content/abstract/scopus_id/85159304682
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-093463-J-100
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108782RB-C22
Serrat, Judit (2025). The role of the fibrinolytic system in the migration of Fasciola hepatica juveniles across the host intestine. http://hdl.handle.net/10261/414641
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
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spelling Fasciola hepatica juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanismSerrat, JuditBecerro Recio, DavidTorres Valle, MaríaSimón Marta, FernandoValero, María AdelaBargues, María DoloresMas-Coma, SantiagoSiles Lucas, MarGonzález Miguel, JavierFasciola hepaticaHost fibrinolytic systemFascioliasisFibrinolysinHost-Parasite InteractionsMass Spectrometry22 páginas, 8 figurasThe trematode Fasciola hepatica is the most widespread causative agent of fasciolosis, a parasitic disease that mainly affects humans and ruminants worldwide. During F. hepatica infection, newly excysted juveniles (FhNEJ) emerge in the duodenum of the mammalian host and migrate towards their definitive location, the intra-hepatic biliary ducts. Understanding how F. hepatica traverses the intestinal wall and migrates towards the liver is pivotal for the development of more successful strategies against fasciolosis. The central enzyme of the mammalian fibrinolytic system is plasmin, a serine protease whose functions are exploited by a number of parasite species owing to its broad spectrum of substrates, including components of tissue extracellular matrices. The aim of the present work is to understand whether FhNEJ co-opt the functions of their host fibrinolytic system as a mechanism to facilitate trans-intestinal migration.This work was supported by the JIN project ‘ULYSSES’ (RTI2018-093463-J-100 to J.G.M.) funded by the Ministerio de Ciencia, Innovación y Universidades (MCIU), Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, UE). IRNASA-CSIC group acknowledges funding received from Project “CLU-2019-05 - IRNASA-CSIC Unit of Excellence”, funded by the Junta de Castilla y León cofunded by the European Union (FEDER “Europe drives our growth”) and funding from the Programme for strengthening research structures "Stairway to excellence" internationalisation aid, cofunded by the Junta de Castilla y León and the European Regional Development Fund. M.S.L.acknowledges the financial support of the Spanish Ministry of Science and Innovation (Project PID2019-108782RB-C22). J.S. and D.B.R. acknowledge the support of the Junta de Castilla y León for their Predoctoral contracts. J.G.M. is supported by the ‘Ramón y Cajal’ program (RYC2020-030575-I) of the Ministerio de Ciencia e Innovación. Valencia centre collaboration funded by: CIBER-Consorcio Centro de Investigación Biomédica en Red- (CB21/13/00056), Instituto de Salud Carlos III, Ministry of Science and Innovation and European Union – NextGenerationEU; the Red de Investigación de Centros de Enfermedades Tropicales - RICET (RD16/0027/0023) of the PN de I+D+I, ISCIII-Subdirección General de Redes y Centros de Investigación Cooperativa RETICS, Ministry of Health and Consumption, Madrid; the PROMETEO Program, Programa de Ayudas para Grupos de Investigación de Excelencia (2021/004), Generalitat Valenciana, Valencia, Spain. The proteomics laboratory where LC-MS/MS analysis was performed is a member of Proteored, PRB3 and is supported by grant PT17/0019, of the PE I+D+i 2013-2016, funded by the Instituto de Salud Carlos III (ISCIII) and the European Regional Development Fund (ERDF). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscriptPeer reviewedPublic Library of ScienceMinisterio de Ciencia, Innovación y Universidades (España)Junta de Castilla y LeónGeneralitat ValencianaMinisterio de Ciencia e Innovación (España)European CommissionSerrat, Judit [0000-0002-1182-1088]Becerro Recio, David [0000-0001-8876-2592]Torres Valle, María [0000-0003-0503-2688]Siles Lucas, Mar [0000-0002-1257-2562]González Miguel, Javier [0000-0003-4279-4761]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/311063https://api.elsevier.com/content/abstract/scopus_id/85159304682reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-093463-J-100info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108782RB-C22Serrat, Judit (2025). The role of the fibrinolytic system in the migration of Fasciola hepatica juveniles across the host intestine. http://hdl.handle.net/10261/414641Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3110632026-05-22T06:33:51Z
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