Dietary patterns and exposure to non-persistent endocrine-disrupting chemicals during pregnancy

Background: Exposure to non-persistent endocrine disrupting chemicals (EDCs) is widespread, causing various adverse health effects, especially during pregnancy. Diet is a major source of EDCs and the identification of dietary patterns that give rise to higher exposure levels is crucial. We aimed to...

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Autores: Warkentin S, Márquez S, Vespalcová H, Knox B, Gascon M, Güil-Oumrait N, González-Palacios S, Gomez Roig MD, Lassale C, Llurba E, Rolland M, Sakhi AK, Thomsen C, Vioque J, Bustamante M, Sunyer J, Vrijheid M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p28797
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28797
Access Level:acceso abierto
Palabra clave:Cohort studies
Pregnancy
Dietary patterns
Diet
Endocrine disruptors
Phthalates
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spelling Dietary patterns and exposure to non-persistent endocrine-disrupting chemicals during pregnancyWarkentin SMárquez SVespalcová HKnox BGascon MGüil-Oumrait NGonzález-Palacios SGomez Roig MDLassale CLlurba ERolland MSakhi AKThomsen CVioque JBustamante MSunyer JVrijheid MCohort studiesPregnancyDietary patternsDietEndocrine disruptorsPhthalatesBackground: Exposure to non-persistent endocrine disrupting chemicals (EDCs) is widespread, causing various adverse health effects, especially during pregnancy. Diet is a major source of EDCs and the identification of dietary patterns that give rise to higher exposure levels is crucial. We aimed to explore the relationship between dietary patterns during pregnancy and exposure to non-persistent EDCs. Methods: We included 640 pregnant women from the Barcelona Life Study Cohort (BiSC), Spain. Using food frequency questionnaires (2nd trimester), we estimated ultraprocessed food (UPF) consumption and Mediterranean diet adherence, and derived data-driven dietary patterns. Metabolites of phthalates, 1,2-cyclohexane dicarboxylic acid di(isononyl) ester (DINCH), chlorpyrifos and pyrethroid, polycyclic aromatic hydrocarbons (PAHs, including phenanthrenes), and organophosphates, and parent compounds of phenols and parabens were measured in weekly urine pools (3rd trimester). Associations between dietary patterns and EDCs were evaluated through multivariable linear regressions. Results: Higher compliance with a "Vegetarian" pattern or the Mediterranean diet was associated with lower levels of some of the phthalate metabolites (e.g., di-iso-nonyl phthalates [Geometric mean ratio (GMR) per unit increases in the "Vegetarian" score = 0.97, 95 %CI 0.95, 1.00]). Conversely, "Western" and "Animal protein" patterns, and UPF intake were associated with higher PAHs (e.g., "Western" and 2-Hydroxynaphthalene [GMR (95 %CI) 1.07(1.01, 1.13)]), pesticides (e.g., "Animal protein" and 3-Phenoxybenzoic acid [1.15(1.01, 1.32]), and phthalates metabolites levels (e.g., UPF and Monoethyl phthalate [1.05(1.01, 1.09)]). No association remained significant after correcting for multiple testing. Conclusions: Following a plant-based diet may help reduce the exposure to certain phthalate and organophosphate metabolites, whereas higher consumption of foods from animal origin and high in fat/sugar/salt may increase exposure to PAHs, pesticides, and phthalates metabolites in pregnancy.PERGAMON-ELSEVIER SCIENCE LTD2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28797ENVIRONMENT INTERNATIONALISSN: 01604120ISSNe: 18736750reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p287972026-05-27T12:37:41Z
dc.title.none.fl_str_mv Dietary patterns and exposure to non-persistent endocrine-disrupting chemicals during pregnancy
title Dietary patterns and exposure to non-persistent endocrine-disrupting chemicals during pregnancy
spellingShingle Dietary patterns and exposure to non-persistent endocrine-disrupting chemicals during pregnancy
Warkentin S
Cohort studies
Pregnancy
Dietary patterns
Diet
Endocrine disruptors
Phthalates
title_short Dietary patterns and exposure to non-persistent endocrine-disrupting chemicals during pregnancy
title_full Dietary patterns and exposure to non-persistent endocrine-disrupting chemicals during pregnancy
title_fullStr Dietary patterns and exposure to non-persistent endocrine-disrupting chemicals during pregnancy
title_full_unstemmed Dietary patterns and exposure to non-persistent endocrine-disrupting chemicals during pregnancy
title_sort Dietary patterns and exposure to non-persistent endocrine-disrupting chemicals during pregnancy
dc.creator.none.fl_str_mv Warkentin S
Márquez S
Vespalcová H
Knox B
Gascon M
Güil-Oumrait N
González-Palacios S
Gomez Roig MD
Lassale C
Llurba E
Rolland M
Sakhi AK
Thomsen C
Vioque J
Bustamante M
Sunyer J
Vrijheid M
author Warkentin S
author_facet Warkentin S
Márquez S
Vespalcová H
Knox B
Gascon M
Güil-Oumrait N
González-Palacios S
Gomez Roig MD
Lassale C
Llurba E
Rolland M
Sakhi AK
Thomsen C
Vioque J
Bustamante M
Sunyer J
Vrijheid M
author_role author
author2 Márquez S
Vespalcová H
Knox B
Gascon M
Güil-Oumrait N
González-Palacios S
Gomez Roig MD
Lassale C
Llurba E
Rolland M
Sakhi AK
Thomsen C
Vioque J
Bustamante M
Sunyer J
Vrijheid M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cohort studies
Pregnancy
Dietary patterns
Diet
Endocrine disruptors
Phthalates
topic Cohort studies
Pregnancy
Dietary patterns
Diet
Endocrine disruptors
Phthalates
description Background: Exposure to non-persistent endocrine disrupting chemicals (EDCs) is widespread, causing various adverse health effects, especially during pregnancy. Diet is a major source of EDCs and the identification of dietary patterns that give rise to higher exposure levels is crucial. We aimed to explore the relationship between dietary patterns during pregnancy and exposure to non-persistent EDCs. Methods: We included 640 pregnant women from the Barcelona Life Study Cohort (BiSC), Spain. Using food frequency questionnaires (2nd trimester), we estimated ultraprocessed food (UPF) consumption and Mediterranean diet adherence, and derived data-driven dietary patterns. Metabolites of phthalates, 1,2-cyclohexane dicarboxylic acid di(isononyl) ester (DINCH), chlorpyrifos and pyrethroid, polycyclic aromatic hydrocarbons (PAHs, including phenanthrenes), and organophosphates, and parent compounds of phenols and parabens were measured in weekly urine pools (3rd trimester). Associations between dietary patterns and EDCs were evaluated through multivariable linear regressions. Results: Higher compliance with a "Vegetarian" pattern or the Mediterranean diet was associated with lower levels of some of the phthalate metabolites (e.g., di-iso-nonyl phthalates [Geometric mean ratio (GMR) per unit increases in the "Vegetarian" score = 0.97, 95 %CI 0.95, 1.00]). Conversely, "Western" and "Animal protein" patterns, and UPF intake were associated with higher PAHs (e.g., "Western" and 2-Hydroxynaphthalene [GMR (95 %CI) 1.07(1.01, 1.13)]), pesticides (e.g., "Animal protein" and 3-Phenoxybenzoic acid [1.15(1.01, 1.32]), and phthalates metabolites levels (e.g., UPF and Monoethyl phthalate [1.05(1.01, 1.09)]). No association remained significant after correcting for multiple testing. Conclusions: Following a plant-based diet may help reduce the exposure to certain phthalate and organophosphate metabolites, whereas higher consumption of foods from animal origin and high in fat/sugar/salt may increase exposure to PAHs, pesticides, and phthalates metabolites in pregnancy.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28797
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28797
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv PERGAMON-ELSEVIER SCIENCE LTD
publisher.none.fl_str_mv PERGAMON-ELSEVIER SCIENCE LTD
dc.source.none.fl_str_mv ENVIRONMENT INTERNATIONAL
ISSN: 01604120
ISSNe: 18736750
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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