Biomonitoring emerging hazards of pharmaceuticals in river water using gut microbiome and behavioural Daphnia magna responses

A cost-effective Daphnia magna testing framework was applied to identify emerging hazards such as neurological and cardiovascular defects as well as antibiotic resistant genes (ARGs), related to pharmaceuticals present in waste water treated (WWTP) effluent discharged into rivers. D. magna juveniles...

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Detalles Bibliográficos
Autores: Moro , Hugo, Vaya, Raquel, Casado, Marta, Piña, Benjamín, Domínguez García, Pol, Gómez-Canela, Cristian
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Ramon Llull (URL)
Repositorio:DAU Arxiu Digital de la Universitat Ramon Llull
OAI Identifier:oai:dau.url.edu:20.500.14342/4632
Acceso en línea:https://hdl.handle.net/20.500.14342/4632
https://doi.org/10.1016/j.chemosphere.2024.143612
Access Level:acceso abierto
Palabra clave:Pharmaceuticals
Antibiotic resistance
Neurotoxic
Daphnia
Wastewater
615
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spelling Biomonitoring emerging hazards of pharmaceuticals in river water using gut microbiome and behavioural Daphnia magna responsesMoro , HugoVaya, RaquelCasado, MartaPiña, BenjamínDomínguez García, PolGómez-Canela, CristianPharmaceuticalsAntibiotic resistanceNeurotoxicDaphniaWastewater615A cost-effective Daphnia magna testing framework was applied to identify emerging hazards such as neurological and cardiovascular defects as well as antibiotic resistant genes (ARGs), related to pharmaceuticals present in waste water treated (WWTP) effluent discharged into rivers. D. magna juveniles were exposed during 48 h to water samples from three rivers in the vicinity of Barcelona (NE Spain), Besós, Llobregat and Onyar, upstream and downstream of WWTP discharging points. The analyses included measuring levels of 80 pharmaceutical residues in water samples by HPLC-MS, determination of the loads of different clinically relevant antibiotic resistant genes (ARGs) in both water samples and exposed animals, and assessment of toxic effects in feeding, heartbeat responses, and behavioural indicators. ARG prevalence in water, but not in gut microbiomes, was associated with the presence of bactericides in water. These results suggest that their levels were high enough to put a selective pressure over river microbial populations, but that Daphnia guts were not easily populated by environmental bacteria. Toxic effects were found in 20–43% of water samples, depending on the river, and related to water quality parameters and to pollutant levels. For example, heartbeats were correlated with salinity, whereas feeding impairment did so with high loads of suspended solids. In contrast, behavioural alterations were associated to the concentration of neuroactive chemicals. Accordingly, we hypothesize that measured neuroactive chemicals have caused the observed effects. If this also applies to local invertebrate populations, the environmental consequences may be severe and unpredictable.info:eu-repo/semantics/publishedVersionElsevierUniversitat Ramon Llull. IQSBarata, Carlos202420242024info:eu-repo/semantics/article11 p.application/pdfhttps://hdl.handle.net/20.500.14342/4632https://doi.org/10.1016/j.chemosphere.2024.143612reponame:DAU Arxiu Digital de la Universitat Ramon Llullinstname:Universitat Ramon Llull (URL)InglésChemosphere. 2024;367:143612info:eu-repo/grantAgreement/EC/TED2021-130845B–C31/info:eu-repo/grantAgreement/EC/TED2021-130845A-C32/info:eu-repo/grantAgreement/MCIN/PN I+D/PID2020-113371RB-C21info:eu-repo/grantAgreement/MCIN/PN I+D/PID2020-113371RA-C22info:eu-repo/grantAgreement/SUR del DEC/SGR/2021SGR00409info:eu-repo/grantAgreement/MCIN i AEI I+D/PRE2021-098251/© L'autor/aAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dau.url.edu:20.500.14342/46322026-06-21T06:40:37Z
dc.title.none.fl_str_mv Biomonitoring emerging hazards of pharmaceuticals in river water using gut microbiome and behavioural Daphnia magna responses
title Biomonitoring emerging hazards of pharmaceuticals in river water using gut microbiome and behavioural Daphnia magna responses
spellingShingle Biomonitoring emerging hazards of pharmaceuticals in river water using gut microbiome and behavioural Daphnia magna responses
Moro , Hugo
Pharmaceuticals
Antibiotic resistance
Neurotoxic
Daphnia
Wastewater
615
title_short Biomonitoring emerging hazards of pharmaceuticals in river water using gut microbiome and behavioural Daphnia magna responses
title_full Biomonitoring emerging hazards of pharmaceuticals in river water using gut microbiome and behavioural Daphnia magna responses
title_fullStr Biomonitoring emerging hazards of pharmaceuticals in river water using gut microbiome and behavioural Daphnia magna responses
title_full_unstemmed Biomonitoring emerging hazards of pharmaceuticals in river water using gut microbiome and behavioural Daphnia magna responses
title_sort Biomonitoring emerging hazards of pharmaceuticals in river water using gut microbiome and behavioural Daphnia magna responses
dc.creator.none.fl_str_mv Moro , Hugo
Vaya, Raquel
Casado, Marta
Piña, Benjamín
Domínguez García, Pol
Gómez-Canela, Cristian
author Moro , Hugo
author_facet Moro , Hugo
Vaya, Raquel
Casado, Marta
Piña, Benjamín
Domínguez García, Pol
Gómez-Canela, Cristian
author_role author
author2 Vaya, Raquel
Casado, Marta
Piña, Benjamín
Domínguez García, Pol
Gómez-Canela, Cristian
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. IQS
Barata, Carlos
dc.subject.none.fl_str_mv Pharmaceuticals
Antibiotic resistance
Neurotoxic
Daphnia
Wastewater
615
topic Pharmaceuticals
Antibiotic resistance
Neurotoxic
Daphnia
Wastewater
615
description A cost-effective Daphnia magna testing framework was applied to identify emerging hazards such as neurological and cardiovascular defects as well as antibiotic resistant genes (ARGs), related to pharmaceuticals present in waste water treated (WWTP) effluent discharged into rivers. D. magna juveniles were exposed during 48 h to water samples from three rivers in the vicinity of Barcelona (NE Spain), Besós, Llobregat and Onyar, upstream and downstream of WWTP discharging points. The analyses included measuring levels of 80 pharmaceutical residues in water samples by HPLC-MS, determination of the loads of different clinically relevant antibiotic resistant genes (ARGs) in both water samples and exposed animals, and assessment of toxic effects in feeding, heartbeat responses, and behavioural indicators. ARG prevalence in water, but not in gut microbiomes, was associated with the presence of bactericides in water. These results suggest that their levels were high enough to put a selective pressure over river microbial populations, but that Daphnia guts were not easily populated by environmental bacteria. Toxic effects were found in 20–43% of water samples, depending on the river, and related to water quality parameters and to pollutant levels. For example, heartbeats were correlated with salinity, whereas feeding impairment did so with high loads of suspended solids. In contrast, behavioural alterations were associated to the concentration of neuroactive chemicals. Accordingly, we hypothesize that measured neuroactive chemicals have caused the observed effects. If this also applies to local invertebrate populations, the environmental consequences may be severe and unpredictable.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14342/4632
https://doi.org/10.1016/j.chemosphere.2024.143612
url https://hdl.handle.net/20.500.14342/4632
https://doi.org/10.1016/j.chemosphere.2024.143612
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Chemosphere. 2024;367:143612
info:eu-repo/grantAgreement/EC/TED2021-130845B–C31/
info:eu-repo/grantAgreement/EC/TED2021-130845A-C32/
info:eu-repo/grantAgreement/MCIN/PN I+D/PID2020-113371RB-C21
info:eu-repo/grantAgreement/MCIN/PN I+D/PID2020-113371RA-C22
info:eu-repo/grantAgreement/SUR del DEC/SGR/2021SGR00409
info:eu-repo/grantAgreement/MCIN i AEI I+D/PRE2021-098251/
dc.rights.none.fl_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DAU Arxiu Digital de la Universitat Ramon Llull
instname:Universitat Ramon Llull (URL)
instname_str Universitat Ramon Llull (URL)
reponame_str DAU Arxiu Digital de la Universitat Ramon Llull
collection DAU Arxiu Digital de la Universitat Ramon Llull
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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