Poly(sulfobetaine methacrylate)/poly(ethylene glycole) hydrogels for chronic wounds management

Polyzwitterions (PZI) recently emerged as biomaterials with excellent bio- and haemo-compatibility, demonstrating lower protein adsorption on their surfaces even compared to the golden standard in the field – poly(ethylene glycol) (PEG). Although PZI combine many beneficial for chronic wound treatme...

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Autores: Ruseva, Konstans, Ivanova, Kristina Dimitrova|||0000-0001-9158-4088, Todorova, Katerina, Gabrashanska, Margarita, Hinojosa-Caballero, Dolores, Tzanov, Tzanko|||0000-0002-8568-1110, Vassileva, Elena
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/134327
Acceso en línea:https://hdl.handle.net/2117/134327
https://dx.doi.org/10.1016/j.eurpolymj.2019.05.022
Access Level:acceso abierto
Palabra clave:Polymers
Biomedical materials
Colloids
Stimuli-responsive polymers
Polyzwitterions
Hydrogel wound dressings
Stimuli responsive swelling behaviour
Biocompatibility Chronic wound healing
Polímers
Materials biomèdics
Col·loides
Àrees temàtiques de la UPC::Enginyeria química
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spelling Poly(sulfobetaine methacrylate)/poly(ethylene glycole) hydrogels for chronic wounds managementRuseva, KonstansIvanova, Kristina Dimitrova|||0000-0001-9158-4088Todorova, KaterinaGabrashanska, MargaritaHinojosa-Caballero, DoloresTzanov, Tzanko|||0000-0002-8568-1110Vassileva, ElenaPolymersBiomedical materialsColloidsStimuli-responsive polymersPolyzwitterionsHydrogel wound dressingsStimuli responsive swelling behaviourBiocompatibility Chronic wound healingPolímersMaterials biomèdicsCol·loidesÀrees temàtiques de la UPC::Enginyeria químicaPolyzwitterions (PZI) recently emerged as biomaterials with excellent bio- and haemo-compatibility, demonstrating lower protein adsorption on their surfaces even compared to the golden standard in the field – poly(ethylene glycol) (PEG). Although PZI combine many beneficial for chronic wound treatment properties as nonfouling ability and high capacity to absorb wound exudate, their potential for such demanding application is still unrevealed. In this work, polysulfobetaine (PSB) networks were synthesized using PEG-based crosslinking agent, thus combining in one material two polymers with inherent antifouling properties. The obtained PSB hydrogels demonstrate linear temperature dependence of their swelling capacity in water between 20 and 70 oC. Moreover, they all exhibit strong antipolyelelctrolyte behavior, increasing their swelling ratio between 10 and 22 times depending on their crosslinking degree as the NaCl concentration increased. The study also demonstrates the PSB high ability to bind water - ~40% bound water was determined for almost all PSB hydrogels, which is considered as the main reason for their ultra-low non-specific protein binding ability. Moreover, PZI networks effectively absorb and retain the major enzymes causing chronicity of the wounds as 30 to 40% myeloperoxidase (MPO) was loaded into the PSB hydrogels depending on their crosslinking degree. At the same time, PZI hydrogels do not inhibit neither MPO nor the collagenase activity, thus ensuring a decrease in their excessive amount in the chronic wounds but at the same not hampering the enzyme activity necessary for the proper wound healing. All PSB hydrogels demonstrated antibiofilm activity against S. aureus, a common bacterial representative in chronic wounds. The non-cytotoxicity and biocompatibility of the hydrogels were proved in vitro and in vivo. Thus, the study demonstrated the PSB hydrogels’ advantages as dressing materials for chronic wound healing, namely: i) high ability to absorb wound exudate; ii) high ability to bind water; iii) good control on the enzymes concentration in the chronic wounds through absorption iv) without inhibiting their activity; v) antibiofilm activity against common for the chronic wounds bacteria; vi) non-cytotoxicity and vii) in vivo proved very good tolerance by the surrounding tissues.Peer ReviewedElsevier20192019-05-1420192019-06-12journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/vnd.openxmlformats-officedocument.wordprocessingml.documenthttps://hdl.handle.net/2117/134327https://dx.doi.org/10.1016/j.eurpolymj.2019.05.022reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1343272026-05-27T15:37:01Z
dc.title.none.fl_str_mv Poly(sulfobetaine methacrylate)/poly(ethylene glycole) hydrogels for chronic wounds management
title Poly(sulfobetaine methacrylate)/poly(ethylene glycole) hydrogels for chronic wounds management
spellingShingle Poly(sulfobetaine methacrylate)/poly(ethylene glycole) hydrogels for chronic wounds management
Ruseva, Konstans
Polymers
Biomedical materials
Colloids
Stimuli-responsive polymers
Polyzwitterions
Hydrogel wound dressings
Stimuli responsive swelling behaviour
Biocompatibility Chronic wound healing
Polímers
Materials biomèdics
Col·loides
Àrees temàtiques de la UPC::Enginyeria química
title_short Poly(sulfobetaine methacrylate)/poly(ethylene glycole) hydrogels for chronic wounds management
title_full Poly(sulfobetaine methacrylate)/poly(ethylene glycole) hydrogels for chronic wounds management
title_fullStr Poly(sulfobetaine methacrylate)/poly(ethylene glycole) hydrogels for chronic wounds management
title_full_unstemmed Poly(sulfobetaine methacrylate)/poly(ethylene glycole) hydrogels for chronic wounds management
title_sort Poly(sulfobetaine methacrylate)/poly(ethylene glycole) hydrogels for chronic wounds management
dc.creator.none.fl_str_mv Ruseva, Konstans
Ivanova, Kristina Dimitrova|||0000-0001-9158-4088
Todorova, Katerina
Gabrashanska, Margarita
Hinojosa-Caballero, Dolores
Tzanov, Tzanko|||0000-0002-8568-1110
Vassileva, Elena
author Ruseva, Konstans
author_facet Ruseva, Konstans
Ivanova, Kristina Dimitrova|||0000-0001-9158-4088
Todorova, Katerina
Gabrashanska, Margarita
Hinojosa-Caballero, Dolores
Tzanov, Tzanko|||0000-0002-8568-1110
Vassileva, Elena
author_role author
author2 Ivanova, Kristina Dimitrova|||0000-0001-9158-4088
Todorova, Katerina
Gabrashanska, Margarita
Hinojosa-Caballero, Dolores
Tzanov, Tzanko|||0000-0002-8568-1110
Vassileva, Elena
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Polymers
Biomedical materials
Colloids
Stimuli-responsive polymers
Polyzwitterions
Hydrogel wound dressings
Stimuli responsive swelling behaviour
Biocompatibility Chronic wound healing
Polímers
Materials biomèdics
Col·loides
Àrees temàtiques de la UPC::Enginyeria química
topic Polymers
Biomedical materials
Colloids
Stimuli-responsive polymers
Polyzwitterions
Hydrogel wound dressings
Stimuli responsive swelling behaviour
Biocompatibility Chronic wound healing
Polímers
Materials biomèdics
Col·loides
Àrees temàtiques de la UPC::Enginyeria química
description Polyzwitterions (PZI) recently emerged as biomaterials with excellent bio- and haemo-compatibility, demonstrating lower protein adsorption on their surfaces even compared to the golden standard in the field – poly(ethylene glycol) (PEG). Although PZI combine many beneficial for chronic wound treatment properties as nonfouling ability and high capacity to absorb wound exudate, their potential for such demanding application is still unrevealed. In this work, polysulfobetaine (PSB) networks were synthesized using PEG-based crosslinking agent, thus combining in one material two polymers with inherent antifouling properties. The obtained PSB hydrogels demonstrate linear temperature dependence of their swelling capacity in water between 20 and 70 oC. Moreover, they all exhibit strong antipolyelelctrolyte behavior, increasing their swelling ratio between 10 and 22 times depending on their crosslinking degree as the NaCl concentration increased. The study also demonstrates the PSB high ability to bind water - ~40% bound water was determined for almost all PSB hydrogels, which is considered as the main reason for their ultra-low non-specific protein binding ability. Moreover, PZI networks effectively absorb and retain the major enzymes causing chronicity of the wounds as 30 to 40% myeloperoxidase (MPO) was loaded into the PSB hydrogels depending on their crosslinking degree. At the same time, PZI hydrogels do not inhibit neither MPO nor the collagenase activity, thus ensuring a decrease in their excessive amount in the chronic wounds but at the same not hampering the enzyme activity necessary for the proper wound healing. All PSB hydrogels demonstrated antibiofilm activity against S. aureus, a common bacterial representative in chronic wounds. The non-cytotoxicity and biocompatibility of the hydrogels were proved in vitro and in vivo. Thus, the study demonstrated the PSB hydrogels’ advantages as dressing materials for chronic wound healing, namely: i) high ability to absorb wound exudate; ii) high ability to bind water; iii) good control on the enzymes concentration in the chronic wounds through absorption iv) without inhibiting their activity; v) antibiofilm activity against common for the chronic wounds bacteria; vi) non-cytotoxicity and vii) in vivo proved very good tolerance by the surrounding tissues.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-05-14
2019
2019-06-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/134327
https://dx.doi.org/10.1016/j.eurpolymj.2019.05.022
url https://hdl.handle.net/2117/134327
https://dx.doi.org/10.1016/j.eurpolymj.2019.05.022
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/vnd.openxmlformats-officedocument.wordprocessingml.document
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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