Transcranial direct current stimulation combined with an intensive training program for upper limb rehabilitation in children with unilateral cerebral palsy. A randomized controlled pilot study

BackgroundUnilateral cerebral palsy (UCP) presents a greater functional alteration of the upper limb. Among the recommended interventions are certain therapeutic tools, such as transcranial direct current stimulation (tDCS) that could increase the therapeutic window and enhance the effect of interve...

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Autores: Muñoz Marrón, Elena, Merino Andrés, Javier, Palomo Carrión, Rocío, Gómez Soriano, Julio, Fernández Pérez, Juan José, Serrano Muñoz, Diego, López Muñoz, Purificación
Formato: artículo
Fecha de publicación:2025
País:España
Recursos:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/43340
Acesso em linha:https://hdl.handle.net/10578/43340
Access Level:acceso abierto
Palavra-chave:Bimanual therapy
Constraint-induced movement therapy
Transcranial direct current stimulation
Unilateral cerebral palsy
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spelling Transcranial direct current stimulation combined with an intensive training program for upper limb rehabilitation in children with unilateral cerebral palsy. A randomized controlled pilot studyMuñoz Marrón, ElenaMerino Andrés, JavierPalomo Carrión, RocíoGómez Soriano, JulioFernández Pérez, Juan JoséSerrano Muñoz, DiegoLópez Muñoz, PurificaciónBimanual therapyConstraint-induced movement therapyTranscranial direct current stimulationUnilateral cerebral palsyBackgroundUnilateral cerebral palsy (UCP) presents a greater functional alteration of the upper limb. Among the recommended interventions are certain therapeutic tools, such as transcranial direct current stimulation (tDCS) that could increase the therapeutic window and enhance the effect of interventions.AimsTo determine the effectiveness of a 3-weeks intervention of cathodal tDCS applied over the motor cortex of the less affected hemisphere combined with a manual function intensive training program in the upper limbs on quality of movement and the spontaneous use of upper limb in children with UCP. Secondarily, quality of life and user´s experience was also assessed.Methods and proceduresA pilot randomized triple-blind clinical trial was conducted. 18 children with UCP between 4 and 8 years were recruited and randomly allocated to one of the two experimental groups: 1) Active group: cathodal tDCS + intensive motor training; 2) Control group: Sham tDCS + intensive motor training. Assessments were performed before and after the intervention, and at three months follow-up.Outcomes and resultsOutcome measures: Shriners Hospital Upper Extremity Evaluation childrens manual experience questionnaire, Paediatric Quality of Life Questionnaire and the Childrens Manual Experience Questionnaire (miniCHEQ). Both groups improved in all variables but in the inter-group analysis only quality of life obtained significant results (p = 0.043).Conclusions and implicationsAdding cathodal tDCS to a program of intensive manual function therapy training did not produce a greater improvement on the spontaneous use, nor improving the experience of use in children with UCP. However, this technique has a short-term beneficial effect on quality of life.Elsevier202520252025info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/10578/43340reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaEspañolinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/433402026-05-27T07:36:41Z
dc.title.none.fl_str_mv Transcranial direct current stimulation combined with an intensive training program for upper limb rehabilitation in children with unilateral cerebral palsy. A randomized controlled pilot study
title Transcranial direct current stimulation combined with an intensive training program for upper limb rehabilitation in children with unilateral cerebral palsy. A randomized controlled pilot study
spellingShingle Transcranial direct current stimulation combined with an intensive training program for upper limb rehabilitation in children with unilateral cerebral palsy. A randomized controlled pilot study
Muñoz Marrón, Elena
Bimanual therapy
Constraint-induced movement therapy
Transcranial direct current stimulation
Unilateral cerebral palsy
title_short Transcranial direct current stimulation combined with an intensive training program for upper limb rehabilitation in children with unilateral cerebral palsy. A randomized controlled pilot study
title_full Transcranial direct current stimulation combined with an intensive training program for upper limb rehabilitation in children with unilateral cerebral palsy. A randomized controlled pilot study
title_fullStr Transcranial direct current stimulation combined with an intensive training program for upper limb rehabilitation in children with unilateral cerebral palsy. A randomized controlled pilot study
title_full_unstemmed Transcranial direct current stimulation combined with an intensive training program for upper limb rehabilitation in children with unilateral cerebral palsy. A randomized controlled pilot study
title_sort Transcranial direct current stimulation combined with an intensive training program for upper limb rehabilitation in children with unilateral cerebral palsy. A randomized controlled pilot study
dc.creator.none.fl_str_mv Muñoz Marrón, Elena
Merino Andrés, Javier
Palomo Carrión, Rocío
Gómez Soriano, Julio
Fernández Pérez, Juan José
Serrano Muñoz, Diego
López Muñoz, Purificación
author Muñoz Marrón, Elena
author_facet Muñoz Marrón, Elena
Merino Andrés, Javier
Palomo Carrión, Rocío
Gómez Soriano, Julio
Fernández Pérez, Juan José
Serrano Muñoz, Diego
López Muñoz, Purificación
author_role author
author2 Merino Andrés, Javier
Palomo Carrión, Rocío
Gómez Soriano, Julio
Fernández Pérez, Juan José
Serrano Muñoz, Diego
López Muñoz, Purificación
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Bimanual therapy
Constraint-induced movement therapy
Transcranial direct current stimulation
Unilateral cerebral palsy
topic Bimanual therapy
Constraint-induced movement therapy
Transcranial direct current stimulation
Unilateral cerebral palsy
description BackgroundUnilateral cerebral palsy (UCP) presents a greater functional alteration of the upper limb. Among the recommended interventions are certain therapeutic tools, such as transcranial direct current stimulation (tDCS) that could increase the therapeutic window and enhance the effect of interventions.AimsTo determine the effectiveness of a 3-weeks intervention of cathodal tDCS applied over the motor cortex of the less affected hemisphere combined with a manual function intensive training program in the upper limbs on quality of movement and the spontaneous use of upper limb in children with UCP. Secondarily, quality of life and user´s experience was also assessed.Methods and proceduresA pilot randomized triple-blind clinical trial was conducted. 18 children with UCP between 4 and 8 years were recruited and randomly allocated to one of the two experimental groups: 1) Active group: cathodal tDCS + intensive motor training; 2) Control group: Sham tDCS + intensive motor training. Assessments were performed before and after the intervention, and at three months follow-up.Outcomes and resultsOutcome measures: Shriners Hospital Upper Extremity Evaluation childrens manual experience questionnaire, Paediatric Quality of Life Questionnaire and the Childrens Manual Experience Questionnaire (miniCHEQ). Both groups improved in all variables but in the inter-group analysis only quality of life obtained significant results (p = 0.043).Conclusions and implicationsAdding cathodal tDCS to a program of intensive manual function therapy training did not produce a greater improvement on the spontaneous use, nor improving the experience of use in children with UCP. However, this technique has a short-term beneficial effect on quality of life.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10578/43340
url https://hdl.handle.net/10578/43340
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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