Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registry

Background: the inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. Methods: retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up from 1 Ma...

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Autores: Rubio-Rivas, Manuel, Corbella, Xavier, Formiga Pérez, Francesc, Menéndez Fernández, Estela, Martín Escalante, María Dolores, Baños Fernández, Isolina, Arnalich Fernández, Francisco, Corral-Beamonte, Esther del, Lalueza, Antonio, Parra Virto, Alejandro, Roy Vallejo, Emilia, Loureiro Amigo, José, Álvarez Suárez, Ana María, Abadía-Otero, Jesica, Navarro de la Chica, María, Estévez González, Raquel, Hernández Milián, Almudena, Areses Manrique, María, Blázquez Encinar, Julio César, González Noya, Amara, González Ferrer, Ruth, Pérez Aguilera, María, Gil Sánchez, Ricardo, Millán Núñez-Cortés, Jesús, Casas Rojo, José, SEMI-COVID-19 Network
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/177973
Acceso en línea:https://hdl.handle.net/2445/177973
Access Level:acceso abierto
Palabra clave:COVID-19
Citoquines
Mortalitat
Cytokines
Mortality
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spelling Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registryRubio-Rivas, ManuelCorbella, XavierFormiga Pérez, FrancescMenéndez Fernández, EstelaMartín Escalante, María DoloresBaños Fernández, IsolinaArnalich Fernández, FranciscoCorral-Beamonte, Esther delLalueza, AntonioParra Virto, AlejandroRoy Vallejo, EmiliaLoureiro Amigo, JoséÁlvarez Suárez, Ana MaríaAbadía-Otero, JesicaNavarro de la Chica, MaríaEstévez González, RaquelHernández Milián, AlmudenaAreses Manrique, MaríaBlázquez Encinar, Julio CésarGonzález Noya, AmaraGonzález Ferrer, RuthPérez Aguilera, MaríaGil Sánchez, RicardoMillán Núñez-Cortés, JesúsCasas Rojo, JoséSEMI-COVID-19 NetworkCOVID-19CitoquinesMortalitatCOVID-19CytokinesMortalityBackground: the inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. Methods: retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish SEMI-COVID-19 Registry. The three categories of low, intermediate, and high risk were determined by taking into consideration the terciles of the total lymphocyte count and the values of C-reactive protein, lactate dehydrogenase, ferritin, and D-dimer taken at the time of admission. Results: a total of 17,122 patients were included in the study. The high-risk group was older (57.9 vs. 64.2 vs. 70.4 years; p < 0.001) and predominantly male (37.5% vs. 46.9% vs. 60.1%; p < 0.001). They had a higher degree of dependence in daily tasks prior to admission (moderate-severe dependency in 10.8% vs. 14.1% vs. 17%; p < 0.001), arterial hypertension (36.9% vs. 45.2% vs. 52.8%; p < 0.001), dyslipidemia (28.4% vs. 37% vs. 40.6%; p < 0.001), diabetes mellitus (11.9% vs. 17.1% vs. 20.5%; p < 0.001), ischemic heart disease (3.7% vs. 6.5% vs. 8.4%; p < 0.001), heart failure (3.4% vs. 5.2% vs. 7.6%; p < 0.001), liver disease (1.1% vs. 3% vs. 3.9%; p = 0.002), chronic renal failure (2.3% vs. 3.6% vs. 6.7%; p < 0.001), cancer (6.5% vs. 7.2% vs. 11.1%; p < 0.001), and chronic obstructive pulmonary disease (5.7% vs. 5.4% vs. 7.1%; p < 0.001). They presented more frequently with fever, dyspnea, and vomiting. These patients more frequently required high flow nasal cannula (3.1% vs. 4.4% vs. 9.7%; p < 0.001), non-invasive mechanical ventilation (0.9% vs. 3% vs. 6.3%; p < 0.001), invasive mechanical ventilation (0.6% vs. 2.7% vs. 8.7%; p < 0.001), and ICU admission (0.9% vs. 3.6% vs. 10.6%; p < 0.001), and had a higher percentage of in-hospital mortality (2.3% vs. 6.2% vs. 23.9%; p < 0.001). The three risk categories proved to be an independent risk factor in multivariate analyses. Conclusion: the present study identifies three risk categories for the requirement of high flow nasal cannula, mechanical ventilation, ICU admission, and in-hospital mortality based on lymphopenia and inflammatory parameters.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/177973Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/jcm10102214Journal of Clinical Medicine, 2021, vol. 10, num. 10, p. 2214https://doi.org/10.3390/jcm10102214cc-by (c) Rubio-Rivas, Manuel et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1779732026-05-27T06:46:51Z
dc.title.none.fl_str_mv Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registry
title Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registry
spellingShingle Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registry
Rubio-Rivas, Manuel
COVID-19
Citoquines
Mortalitat
COVID-19
Cytokines
Mortality
title_short Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registry
title_full Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registry
title_fullStr Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registry
title_full_unstemmed Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registry
title_sort Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registry
dc.creator.none.fl_str_mv Rubio-Rivas, Manuel
Corbella, Xavier
Formiga Pérez, Francesc
Menéndez Fernández, Estela
Martín Escalante, María Dolores
Baños Fernández, Isolina
Arnalich Fernández, Francisco
Corral-Beamonte, Esther del
Lalueza, Antonio
Parra Virto, Alejandro
Roy Vallejo, Emilia
Loureiro Amigo, José
Álvarez Suárez, Ana María
Abadía-Otero, Jesica
Navarro de la Chica, María
Estévez González, Raquel
Hernández Milián, Almudena
Areses Manrique, María
Blázquez Encinar, Julio César
González Noya, Amara
González Ferrer, Ruth
Pérez Aguilera, María
Gil Sánchez, Ricardo
Millán Núñez-Cortés, Jesús
Casas Rojo, José
SEMI-COVID-19 Network
author Rubio-Rivas, Manuel
author_facet Rubio-Rivas, Manuel
Corbella, Xavier
Formiga Pérez, Francesc
Menéndez Fernández, Estela
Martín Escalante, María Dolores
Baños Fernández, Isolina
Arnalich Fernández, Francisco
Corral-Beamonte, Esther del
Lalueza, Antonio
Parra Virto, Alejandro
Roy Vallejo, Emilia
Loureiro Amigo, José
Álvarez Suárez, Ana María
Abadía-Otero, Jesica
Navarro de la Chica, María
Estévez González, Raquel
Hernández Milián, Almudena
Areses Manrique, María
Blázquez Encinar, Julio César
González Noya, Amara
González Ferrer, Ruth
Pérez Aguilera, María
Gil Sánchez, Ricardo
Millán Núñez-Cortés, Jesús
Casas Rojo, José
SEMI-COVID-19 Network
author_role author
author2 Corbella, Xavier
Formiga Pérez, Francesc
Menéndez Fernández, Estela
Martín Escalante, María Dolores
Baños Fernández, Isolina
Arnalich Fernández, Francisco
Corral-Beamonte, Esther del
Lalueza, Antonio
Parra Virto, Alejandro
Roy Vallejo, Emilia
Loureiro Amigo, José
Álvarez Suárez, Ana María
Abadía-Otero, Jesica
Navarro de la Chica, María
Estévez González, Raquel
Hernández Milián, Almudena
Areses Manrique, María
Blázquez Encinar, Julio César
González Noya, Amara
González Ferrer, Ruth
Pérez Aguilera, María
Gil Sánchez, Ricardo
Millán Núñez-Cortés, Jesús
Casas Rojo, José
SEMI-COVID-19 Network
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
Citoquines
Mortalitat
COVID-19
Cytokines
Mortality
topic COVID-19
Citoquines
Mortalitat
COVID-19
Cytokines
Mortality
description Background: the inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. Methods: retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish SEMI-COVID-19 Registry. The three categories of low, intermediate, and high risk were determined by taking into consideration the terciles of the total lymphocyte count and the values of C-reactive protein, lactate dehydrogenase, ferritin, and D-dimer taken at the time of admission. Results: a total of 17,122 patients were included in the study. The high-risk group was older (57.9 vs. 64.2 vs. 70.4 years; p < 0.001) and predominantly male (37.5% vs. 46.9% vs. 60.1%; p < 0.001). They had a higher degree of dependence in daily tasks prior to admission (moderate-severe dependency in 10.8% vs. 14.1% vs. 17%; p < 0.001), arterial hypertension (36.9% vs. 45.2% vs. 52.8%; p < 0.001), dyslipidemia (28.4% vs. 37% vs. 40.6%; p < 0.001), diabetes mellitus (11.9% vs. 17.1% vs. 20.5%; p < 0.001), ischemic heart disease (3.7% vs. 6.5% vs. 8.4%; p < 0.001), heart failure (3.4% vs. 5.2% vs. 7.6%; p < 0.001), liver disease (1.1% vs. 3% vs. 3.9%; p = 0.002), chronic renal failure (2.3% vs. 3.6% vs. 6.7%; p < 0.001), cancer (6.5% vs. 7.2% vs. 11.1%; p < 0.001), and chronic obstructive pulmonary disease (5.7% vs. 5.4% vs. 7.1%; p < 0.001). They presented more frequently with fever, dyspnea, and vomiting. These patients more frequently required high flow nasal cannula (3.1% vs. 4.4% vs. 9.7%; p < 0.001), non-invasive mechanical ventilation (0.9% vs. 3% vs. 6.3%; p < 0.001), invasive mechanical ventilation (0.6% vs. 2.7% vs. 8.7%; p < 0.001), and ICU admission (0.9% vs. 3.6% vs. 10.6%; p < 0.001), and had a higher percentage of in-hospital mortality (2.3% vs. 6.2% vs. 23.9%; p < 0.001). The three risk categories proved to be an independent risk factor in multivariate analyses. Conclusion: the present study identifies three risk categories for the requirement of high flow nasal cannula, mechanical ventilation, ICU admission, and in-hospital mortality based on lymphopenia and inflammatory parameters.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/177973
url https://hdl.handle.net/2445/177973
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jcm10102214
Journal of Clinical Medicine, 2021, vol. 10, num. 10, p. 2214
https://doi.org/10.3390/jcm10102214
dc.rights.none.fl_str_mv cc-by (c) Rubio-Rivas, Manuel et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Rubio-Rivas, Manuel et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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