Comparative genomic analysis of the odorant-binding protein family in 12 Drosophila genomes: purifying selection and birth-and-death evolution

The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2007/8/11/R235

Detalles Bibliográficos
Autores: Vieira, Filipe G., Rozas, Julio, Sánchez-Gracia, Alejandro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2007
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/3326
Acceso en línea:http://hdl.handle.net/10261/3326
Access Level:acceso abierto
Palabra clave:Evolution
Genome studies
Model organisms
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spelling Comparative genomic analysis of the odorant-binding protein family in 12 Drosophila genomes: purifying selection and birth-and-death evolutionVieira, Filipe G.Rozas, JulioSánchez-Gracia, AlejandroEvolutionGenome studiesModel organismsThe electronic version of this article is the complete one and can be found online at http://genomebiology.com/2007/8/11/R235[Background] Chemoreception is a widespread mechanism that is involved in critical biologic processes, including individual and social behavior. The insect peripheral olfactory system comprises three major multigene families: the olfactory receptor (Or), the gustatory receptor (Gr), and the odorant-binding protein (OBP) families. Members of the latter family establish the first contact with the odorants, and thus constitute the first step in the chemosensory transduction pathway.[Results] Comparative analysis of the OBP family in 12 Drosophila genomes allowed the identification of 595 genes that encode putative functional and nonfunctional members in extant species, with 43 gene gains and 28 gene losses (15 deletions and 13 pseudogenization events). The evolution of this family shows tandem gene duplication events, progressive divergence in DNA and amino acid sequence, and prevalence of pseudogenization events in external branches of the phylogenetic tree. We observed that the OBP arrangement in clusters is maintained across the Drosophila species and that purifying selection governs the evolution of the family; nevertheless, OBP genes differ in their functional constraints levels. Finally, we detect that the OBP repertoire evolves more rapidly in the specialist lineages of the Drosophila melanogaster group (D. sechellia and D. erecta) than in their closest generalists.[Conclusion] Overall, the evolution of the OBP multigene family is consistent with the birth-anddeath model. We also found that members of this family exhibit different functional constraints, which is indicative of some functional divergence, and that they might be involved in some of the specialization processes that occurred through the diversification of the Drosophila genus.This work was funded by grant BFU2004-02253 from the Dirección General de Investigación Científica y Técnica (Spain), and by grant 2005SGR00166 from Comissió Interdepartamental de Recerca i Innovació Tecnològica de Catalunya (Spain).Peer reviewedBioMed Central200820082007info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersion23040 bytes1500290 bytes47104 bytes165777 bytes1308160 bytes111104 bytesapplication/vnd.ms-excelapplication/pdfapplication/vnd.ms-powerpointapplication/postscriptapplication/vnd.ms-powerpointapplication/vnd.ms-excelhttp://hdl.handle.net/10261/3326reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglésinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/33262026-05-22T06:33:51Z
dc.title.none.fl_str_mv Comparative genomic analysis of the odorant-binding protein family in 12 Drosophila genomes: purifying selection and birth-and-death evolution
title Comparative genomic analysis of the odorant-binding protein family in 12 Drosophila genomes: purifying selection and birth-and-death evolution
spellingShingle Comparative genomic analysis of the odorant-binding protein family in 12 Drosophila genomes: purifying selection and birth-and-death evolution
Vieira, Filipe G.
Evolution
Genome studies
Model organisms
title_short Comparative genomic analysis of the odorant-binding protein family in 12 Drosophila genomes: purifying selection and birth-and-death evolution
title_full Comparative genomic analysis of the odorant-binding protein family in 12 Drosophila genomes: purifying selection and birth-and-death evolution
title_fullStr Comparative genomic analysis of the odorant-binding protein family in 12 Drosophila genomes: purifying selection and birth-and-death evolution
title_full_unstemmed Comparative genomic analysis of the odorant-binding protein family in 12 Drosophila genomes: purifying selection and birth-and-death evolution
title_sort Comparative genomic analysis of the odorant-binding protein family in 12 Drosophila genomes: purifying selection and birth-and-death evolution
dc.creator.none.fl_str_mv Vieira, Filipe G.
Rozas, Julio
Sánchez-Gracia, Alejandro
author Vieira, Filipe G.
author_facet Vieira, Filipe G.
Rozas, Julio
Sánchez-Gracia, Alejandro
author_role author
author2 Rozas, Julio
Sánchez-Gracia, Alejandro
author2_role author
author
dc.subject.none.fl_str_mv Evolution
Genome studies
Model organisms
topic Evolution
Genome studies
Model organisms
description The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2007/8/11/R235
publishDate 2007
dc.date.none.fl_str_mv 2007
2008
2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
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info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/3326
url http://hdl.handle.net/10261/3326
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
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