Replication Study Of Polymorphisms Associated With Response To Methotrexate In Patients With Rheumatoid Arthritis

About 70 genetic studies have already addressed the need of biomarkers to predict the response of patients with rheumatoid arthritis (RA) to methotrexate (MTX) treatment. However, no genetic biomarker has yet been sufficiently validated. Here, we aimed to replicate a selection of 25 SNPs in the larg...

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Detalhes bibliográficos
Autores: López-Rodríguez, Rosario, Ferreiro-Iglesias, Aida, Lima, Aurea, Bernardes, Miguel, Pawlik, Andrzej, Paradowska-Gorycka, Agnieszka, Swierkot, Jerzy, Slezak, Ryszard, Dolzan, Vita, González Álvaro, Isidoro, Narváez García, Francisco Javier, Cáliz, Rafael, Perez-Pampin, Eva, Mera-Varela, Antonio, Vidal-Bralo, Laura, Acuña Ochoa, José Gorgonio, Conde, Carmen, Gomez Reino, Juan J., González, Antonio
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2018
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/123924
Acesso em linha:https://hdl.handle.net/2445/123924
Access Level:Acceso aberto
Palavra-chave:Metotrexat
Artritis reumatoide
Polimorfisme genètic
Methotrexate
Rheumatoid arthritis
Genetic polymorphisms
Descrição
Resumo:About 70 genetic studies have already addressed the need of biomarkers to predict the response of patients with rheumatoid arthritis (RA) to methotrexate (MTX) treatment. However, no genetic biomarker has yet been sufficiently validated. Here, we aimed to replicate a selection of 25 SNPs in the largest collection of patients up to date, which consisted of 915 patients treated with MTX. The change in disease activity (measured as.DAS28) from baseline was considered the primary outcome. In addition, response according to widely used criteria (EULAR) was taken as secondary outcome. We considered consistency between outcomes, P values accounting for the number of SNPs, and independence from potential confounders for interpretation of the results. Only the rs1801394 SNP in MTRR fulfilled the high association standards. Its minor allele was associated with less improvement than the major allele according to.DAS28 (p = 0.0016), and EULAR response (p = 0.004), with independence of sex, age, baseline DAS28, smoking, seropositivity, concomitant corticosteroid use or previous treatments. In addition, previous evidence suggests the association of this SNP with response to MTX in another autoimmune disease, juvenile idiopathic arthritis, and with high intracellular folate levels, which could contribute to poor response.

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