Effects of Chlorella vulgaris, Microchloropsis Gaditana and Gracilaria vermiculophylla algae extracts on maturing and mature 3T3-L1 adipocytes

The datasets generated and/or analysed during the current study are not publicly available due to they are going to be used in an undergoing publication where some correlations are going to be generated but are available from the corresponding author on reasonable request.

Detalhes bibliográficos
Autores: González-Arceo, Maitane, Aguirre, Leixuri, Ibarruri, Jone, Cebrián, Marta, Martín, M. Ángeles, Portillo, María P., Gómez-Zorita, Saioa
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/410215
Acesso em linha:http://hdl.handle.net/10261/410215
Access Level:Acceso aberto
id ES_2e069b6172e67a1e080d7034fafc8954
oai_identifier_str oai:digital.csic.es:10261/410215
network_acronym_str ES
network_name_str España
repository_id_str
spelling Effects of Chlorella vulgaris, Microchloropsis Gaditana and Gracilaria vermiculophylla algae extracts on maturing and mature 3T3-L1 adipocytesGonzález-Arceo, MaitaneAguirre, LeixuriIbarruri, JoneCebrián, MartaMartín, M. ÁngelesPortillo, María P.Gómez-Zorita, SaioaThe datasets generated and/or analysed during the current study are not publicly available due to they are going to be used in an undergoing publication where some correlations are going to be generated but are available from the corresponding author on reasonable request.The prevalence of obesity is increasing worldwide, and it is a risk factor for various metabolic disorders. White adipose tissue expansion depends on hyperplasia and hypertrophy of adipocytes, thus the search for new tools that target these two processes is relevant for the prevention and treatment of obesity. Algae are an interesting source of bioactive compounds and have been demonstrated to exert beneficial health effects. Therefore, this study aims at analysing the effects on adipogenesis and triglyceride accumulation of peptide- and protein-rich extracts obtained from the microalgae Chlorella vulgaris and Microchloropsis gaditana and the macroalga Gracilaria vermiculophylla. 3T3-L1 pre-adipocytes and mature adipocytes were incubated with each of the extracts at 10, 25, 50 and 150 µg/mL. The extracts were found to reduce triglyceride content in maturing pre-adipocytes, without cytotoxic effects. Although, in all cases, it seems that the extracts cannot act throughout the whole adipogenic process, they are effective in suppressing pre-adipocyte differentiation, to a greater or lesser extent. This effect is most likely mediated mainly by the transcription factor C/EBPα. Under our experimental conditions, the extracts used in the present study are effective in inhibiting adipogenesis but they are not able to reduce triglyceride accumulation in mature adipocytes.Open Access funding provided by University of Basque Country (UPV/EHU).This study was supported by Instituto de Salud Carlos III (CIBERobn) under Grant CB12/03/30007, the Government of the Basque Country under Grants KK-2019-00031 and IT1482-22, the Grant TED2021-129711B-I00, funded by MCIN/AEI/https://doi.org/10.13039/501100011033 and, as appropriate, by “ERDF A way of making Europe”, by the “European Union” or by the “European Union NextGenerationEU/PRTR”.Peer reviewedSpringer NatureUniversidad del País VascoEusko JaurlaritzaInstituto de Salud Carlos IIIAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/410215reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/TED2021-129711B-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1038/s41598-025-10202-yhttps://doi.org/10.1038/s41598-025-10202-ySíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4102152026-05-22T06:33:51Z
dc.title.none.fl_str_mv Effects of Chlorella vulgaris, Microchloropsis Gaditana and Gracilaria vermiculophylla algae extracts on maturing and mature 3T3-L1 adipocytes
title Effects of Chlorella vulgaris, Microchloropsis Gaditana and Gracilaria vermiculophylla algae extracts on maturing and mature 3T3-L1 adipocytes
spellingShingle Effects of Chlorella vulgaris, Microchloropsis Gaditana and Gracilaria vermiculophylla algae extracts on maturing and mature 3T3-L1 adipocytes
González-Arceo, Maitane
title_short Effects of Chlorella vulgaris, Microchloropsis Gaditana and Gracilaria vermiculophylla algae extracts on maturing and mature 3T3-L1 adipocytes
title_full Effects of Chlorella vulgaris, Microchloropsis Gaditana and Gracilaria vermiculophylla algae extracts on maturing and mature 3T3-L1 adipocytes
title_fullStr Effects of Chlorella vulgaris, Microchloropsis Gaditana and Gracilaria vermiculophylla algae extracts on maturing and mature 3T3-L1 adipocytes
title_full_unstemmed Effects of Chlorella vulgaris, Microchloropsis Gaditana and Gracilaria vermiculophylla algae extracts on maturing and mature 3T3-L1 adipocytes
title_sort Effects of Chlorella vulgaris, Microchloropsis Gaditana and Gracilaria vermiculophylla algae extracts on maturing and mature 3T3-L1 adipocytes
dc.creator.none.fl_str_mv González-Arceo, Maitane
Aguirre, Leixuri
Ibarruri, Jone
Cebrián, Marta
Martín, M. Ángeles
Portillo, María P.
Gómez-Zorita, Saioa
author González-Arceo, Maitane
author_facet González-Arceo, Maitane
Aguirre, Leixuri
Ibarruri, Jone
Cebrián, Marta
Martín, M. Ángeles
Portillo, María P.
Gómez-Zorita, Saioa
author_role author
author2 Aguirre, Leixuri
Ibarruri, Jone
Cebrián, Marta
Martín, M. Ángeles
Portillo, María P.
Gómez-Zorita, Saioa
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad del País Vasco
Eusko Jaurlaritza
Instituto de Salud Carlos III
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description The datasets generated and/or analysed during the current study are not publicly available due to they are going to be used in an undergoing publication where some correlations are going to be generated but are available from the corresponding author on reasonable request.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/410215
url http://hdl.handle.net/10261/410215
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/TED2021-129711B-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1038/s41598-025-10202-y
https://doi.org/10.1038/s41598-025-10202-y
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405375564873728
score 15.812429

Registros relacionados